Nanoaggregate‐Embedded Beads as Novel Raman Labels for Biodetection

Abstract

Novel Raman tags called nanoaggregate‐embedded beads (NAEBs) have been developed. NAEBs are silica‐coated, dye‐induced aggregates of a small number of metal nanoparticles. In this work, the Raman reporters used to induce aggregation of gold nanoparticles include strongly binding dyes such as XRITC, TRITC, and DTDC and weakly binding dyes such as R6G. Surface‐enhanced Raman scattering (SERS) signal from a single NAEB can be detected. This study also demonstrates that these SERS‐active beads can be used as Raman tags for bio‐detection.

Size‐Tunable Highly Luminescent SiO2 Particles Impregnated with Number‐Adjusted CdTe Nanocrystals

“…Aggregation of Au NCs was reported to decrease with increasing amount of MPS in the solution, but a possible reason was not given. [27] This might be due to the surface charge of MPS after hydrolysis. When a large amount of MPS was added, a dense MPS layer formed on the surface of the CdTe NCs.…”

Effects of solid substrate on the SERS‐based immunoassay: a comparative study

“…Most of the researchers have focused on the third step in preparing these labeled gold nanoparticles to obtain a stable structure with good biocompatibility, high SERS ability, and homogeneous characteristics. So far, many novel structures have been developed, such as composite organic-inorganic nanoparticles (COINs), [9,10] core-shell, [11,12] hollow gold nanospheres (HGNs), [13] aggregates [14,15] and so on. In fact, the immune substrate is also a key point among the three components in immunoassay.…”

Nanoplatforms for Raman Molecular Imaging in Biological Systems

“…Another type of SERS beads have Raman dye labeled small Ag or Au nanoparticles aggregated in the nucleus, and an outer lay of polymer or silica coating to envelop the beads (Fig. 9.6c) [51,52]. Composite organic-inorganic nanoparticles (COINs) developed by Intel Corp. fall into this category [54,55].…”