Nano-zeolite efficiency to mitigate the aflatoxin B1 (AFB1) toxicity: Effects on growth, digestive enzymes, antioxidant, DNA damage and bioaccumulation of AFB1 residues in Nile tilapia (Oreochromis niloticus)

Hassaan, Mohamed S.; Nssar, Khaled M.; Mohammady, Eman Y.; Amin, Alaa S.; Tayel, Safaa I.; El‐Haroun, Ehab

doi:10.1016/j.aquaculture.2020.735123

Cited by 49 publications

(28 citation statements)

References 76 publications

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“…Finally, Hussain et al . () showed a high deposition of AF in tilapia muscle, however, the levels of mycotoxins used in this trial (2,000–4,000 μg kg −1 ) are unlikely to be found in aquafeeds although TFs calculated for AF deposition in the liver are in line with the other studies. The only trial with red tilapia ( O. niloticus × O. mossambicus ), (Usanno et al .…”

Section: Carry‐over Of Mycotoxinssupporting

confidence: 81%

See 1 more Smart Citation

Mycotoxins in aquaculture: feed and food

Gonçalves

Schatzmayr²,

Albalat

et al. 2018

Reviews in Aquaculture

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Mycotoxins, secondary metabolites produced by moulds, are responsible for causing significant economic losses due to spoilage of agricultural products but also due to direct or indirect health impact on livestock upon ingestion of mycotoxin contaminated feedstuffs. Aquaculture farmed species are not an exception and studies reporting mycotoxin‐related issues in the aquaculture industry have been increasing. However, our understanding on the prevalence and impact of mycotoxins in the aquaculture sector is still lower compared to the terrestrial livestock sector. Consequently, regulatory limits and guidance values have been defined based on the studies on terrestrial farm animals. The aim of this review is to compile and critically assess mycotoxin occurrence and co‐occurrence in aquaculture finished feeds, and understand the risk of mycotoxin carry‐over in aquaculture seafood products. Furthermore, we aim with this review to raise awareness to the scientific community, the regulatory authorities and the aquaculture industry to the need for specific aquaculture mycotoxin maximum concentration levels for both aquaculture feeds and foods.

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Section: Carry‐over Of Mycotoxinssupporting

confidence: 81%

“…From all the studies regarding AF carry‐over presented in Table , a few of them should be excluded due to the use of high levels of AFs (Hussain et al . ); or higher dosages, which are not normally observed in commercial feeds (Boonyaratpalin et al . ; Usanno et al .…”

Section: Carry‐over Of Mycotoxinsmentioning

confidence: 99%

Mycotoxins in aquaculture: feed and food

Gonçalves

Schatzmayr²,

Albalat

et al. 2018

Reviews in Aquaculture

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“…The adverse effects of higher level of AFB 1 in diet on growth performance had been reported in several fish species. In nile tilapia, diets with AFB 1 (2000 or 4000 μg/kg) remarkably reduced the weight gain (WG), FE, and the content of crude lipid [ 23 ], while results reported by Tuan et al [ 25 ] and Deng et al [ 26 ] demonstrated that WG, FI and FE were significantly reduced by 250 μg/kg or higher dietary AFB 1 . A similar result was also showed in tambaqui (500 μg/kg or higher level of AFB 1 ) [ 36 ].…”

Section: Discussionmentioning

confidence: 99%

“…Studies on rainbow trout ( Oncorhynchus mykiss ) indicated that toxic effects of AFB 1 could be induced when fish were fed more than 0.05 μg AFB 1 /kg diet [ 17 , 18 , 19 , 20 , 21 , 22 ]. There was also plenty of research in nile tilapia ( Oreochromis niloticus ) [ 23 , 24 , 25 , 26 ], the poor growth performance was caused by more than 250 μg AFB 1 /kg in diet. Other relevant studies also included gibel carp ( Carassius auratus gibelio ) [ 27 , 28 , 29 ], grass carp ( Ctenopharyngodon idella ) [ 30 ], rohu ( Labeo rohita ) [ 31 , 32 , 33 ], red tilapia ( O. niloticus × O .…”

Section: Introductionmentioning

confidence: 99%

The Assessment of Diet Contaminated with Aflatoxin B1 in Juvenile Turbot (Scophthalmus maximus) and the Evaluation of the Efficacy of Mitigation of a Yeast Cell Wall Extract

Yang

Wang

Lin

et al. 2020

Toxins

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This study aimed to investigate the effects of dietary AFB1 on growth performance, health, intestinal microbiota communities and AFB1 tissue residues of turbot and evaluate the mitigation efficacy of yeast cell wall extract, Mycosorb® (YCWE) toward AFB1 contaminated dietary treatments. Nine experimental diets were formulated: Diet 1 (control): AFB1 free; Diets 2–5 or Diets 6–9: 20 μg AFB1/kg diet or 500 μg AFB1/kg diet + 0%, 0.1%, 0.2%, or 0.4% YCWE, respectively). The results showed that Diet 6 significantly decreased the concentrations of TP, GLB, C3, C4, T-CHO, TG but increased the activities of AST, ALT in serum, decreased the expressions of CAT, SOD, GPx, CYP1A but increased the expressions of CYP3A, GST-1, p53 in liver. Diet 6 increased the AFB1 residues in serum and muscle, altered the intestinal microbiota composition, decreased the bacterial community diversity and the abundance of some potential probiotics. However, Diet 8 and Diet 9 restored the immune response, relieved adverse effects in liver, lowered the AFB1 residues in turbot tissues, promoted intestinal microbiota diversity and lowered the abundance of potentially pathogens. In conclusion, YCWE supplementation decreased the health effects of AFB1 on turbot, restoring biomarkers closer to the mycotoxin-free control diet.

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“…in Nile tilapia ( Oreochromis niloticus ). Hassan et al [ 35 ] also observed an increase in malondialdehyde (MDA) levels and a decrease in superoxide dismutase (SOD), CAT and lysozyme activities in an 84-day long experiment with Nile tilapia consuming contaminated feed at a concentration of 3 mg AFB1/kg. Similar observations were made by Abdel-Daim et al [ 36 ] in a 30-day long experiment with 2.5 mg AFB1/kg feed exposure in which a decrease in GSH content, GPx, SOD, and CAT activity, and an increase in MDA were observed at the applied concentration.…”

Section: Introductionmentioning

confidence: 99%

Individual and Combined Effects of Aflatoxin B1 and Sterigmatocystin on Lipid Peroxidation and Glutathione Redox System of Common Carp Liver

Kövesi

Kulcsár

Ancsin

et al. 2021

Toxins

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The purpose of the study was to evaluate the short-term effects of aflatoxin B1 (AFB1 100 µg/kg feed) and sterigmatocystin (STC 1000 μg/kg feed) exposure individually and in combination (100 μg AFB1 + 1000 μg STC/kg feed) on the parameters of lipid peroxidation and glutathione redox system both in biochemical and gene expression levels in one-year-old common carp. Lipid peroxidation parameters were slightly affected, as significant differences were observed only in conjugated diene and triene concentrations. Reduced glutathione content decreased more markedly by STC than AFB1 or AFB1+STC, but glutathione peroxidase activity did not change. Expression of gpx4a, gpx4b, gss, and gsr genes was down-regulated due to STC compared to AFB1 or AFB1+STC, while an induction was found as effect of AFB1+STC in the case of gpx4a, but down-regulation for gpx4b as compared to AFB1. Expression of the glutathione biosynthesis regulatory gene, gss, was higher, but glutathione recycling enzyme encoding gene, gsr, was lower as an effect of AFB1+STC compared to AFB1. These results are supported by the changes in the expression of transcription factors encoding genes, nrf2, and keap1. The results revealed that individual effects of AFB1 and STC on different parameters are synergistic or antagonistic in multi-toxin treatment.

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Nano-zeolite efficiency to mitigate the aflatoxin B1 (AFB1) toxicity: Effects on growth, digestive enzymes, antioxidant, DNA damage and bioaccumulation of AFB1 residues in Nile tilapia (Oreochromis niloticus)

Cited by 49 publications

References 76 publications

Mycotoxins in aquaculture: feed and food

Mycotoxins in aquaculture: feed and food

The Assessment of Diet Contaminated with Aflatoxin B1 in Juvenile Turbot (Scophthalmus maximus) and the Evaluation of the Efficacy of Mitigation of a Yeast Cell Wall Extract

Individual and Combined Effects of Aflatoxin B1 and Sterigmatocystin on Lipid Peroxidation and Glutathione Redox System of Common Carp Liver

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