Concrete pavement is one of the most important forms of highway pavement because it requires less maintenance, consumes less energy, has a simple structure and is highly adaptable to the environment. However, ordinary cement concrete has shortcomings such as high brittleness and low strength, and its application in road construction is limited. This article aims to study the influence of nano-SiO2 reinforced polyurethane road grouting materials on the flexural strength and durability of road concrete, and analyze the properties of commonly used polymer chemical grouting materials, nano-materials, the application of nano-materials in concrete, and the characteristics of nano-SiO2. Based on the damage of concrete joints and the common shrinkage in concrete engineering, the influence of nano-SiO2 materials mixed into concrete at different dosages was studied from the perspective of mechanical properties and durability. The test proves that when the content of nano-SiO2 reaches 2%, the compressive and flexural strengths of 3d, 7d and 28d reach the maximum. Nano-SiO2 reinforced polyurethane road grouting material improves the strength of road concrete and improves the early strength of concrete.