Nano-Transfersomes of Vitamin-E and Aloe-Vera for The Management of Psoriasis

Abstract

Psoriasis is a topical disease that leads to red and scratchy skin, most commonly on the knees, elbows, trunk and scalp. Psoriasis is an inflammatory constrains, and aloe-vera, a natural product, reported to have anti-inflammatory properties. Further, Vitamin-E has antioxidant properties and it can aid to protect against some of the oxidative burden that occurs with psoriasis. Naturally, vitamin E has broad spectrum benefits for health, skin, and hair. The aim of present research was to prepare and characterized Nano-Transfersomes of Vitamin-E and aloe-verafor the management of psoriasis. Nano-Transfersomespharmaceutical formulation was prepared and evaluated for particle size, Zeta potential, drug entrapment, shape and surface morphology, pH, viscosity, in vitrodrug release, skin irritation and in vitrostability. The mean size, poly disparityindex (PDI), Zeta potential and entrapment efficiency of optimized Nano-transfersomal vesicles prepared were 146.8±0.98 nm, 0.593, -38.5 Mv and 92.29±4.51% respectively. The prepared formulation revealed prolonged drug release during the study of 24h and results revealed that the drug is more permeable through the egg membrane from Nano-Transfersomes gel formulation in comparison to marketed formulation (Vitamin E Gel Moisture Cream). Vitamin-E and aloe-vera containing Nano-Transfersomes was found to be highly efficacious as topical formulation, as optimized preparation indicated no any evidence of skin irritancy in mice. The present formulation indicated the compatibility of formulations with skin which divulged the therapeutic efficacy of natural formulation in sustainable, biodegradable and biocompatible manner in the management of psoriasis.