Nano Transdermal Delivery Potential of Fucoidan from Sargassum sp. (Brown Algae) as Chemoprevention Agent for Breast Cancer Treatment

Abstract

Conventional chemotherapy substances are associated with mild to severe side effects that affect both healthy and cancer cells. It is presumed to improve therapeutic efficacy in coexistence reducing chemotherapy's side effects. Fucoidan is an anticancer bioactive compound derived from Sargassum sp. that has low cytotoxic activity. The purpose of this study was to explore the effectiveness of anticancer activities of fucoidan from Sargassum sp. against breast cancer then analyze the suitability of nano transdermal patch of fucoidan and blueprint the long-term research design of nano transdermal patch as a chemoprevention agent in the chemotherapeutic management of breast cancer. This research was performed through a literature study and in silico study by imposing carbonic anhydrase IX (CA IX) as a marker of hypoxia and metastatic state of cancer cells. The results showed that the fucoidan from Sargassum sp. effectively induced apoptosis and prevented metastasis of breast cancer cells through the Bcl-2, Bcl-w, and bad pathways. Fucoidan, in addition, was predicted to inhibit CA IX by Glu4 Glu5, Leu7, Pro8, and Asp6 residues. Therefore, the delivery of fucoidan is favored to have a local effect on the site of breast cancer cells by nano transdermal patch preparations using fucoidan nanoparticle polymer. Further nano transdermal patch development as a treatment for breast cancer is suggested through the stages of formulation optimization, optimum formula activity testing, patent filing, and distribution in health services.

Long non-coding RNA HANR modulates the glucose metabolism of triple negative breast cancer via stabilizing hexokinase 2

“…These conclusions were mainly obtained by in vitro assays, more in vivo studies, especially the patient derived xenograft models, are needed to confirm the regulatory mechanism of HANR/HK2 axis, which would enhance the robustness and translational relevance of the study. Recent study reported that nano transdermal delivery of fucoidan, an anticancer bioactive compound derived from Sargassum sp., showed local effects on the site of breast cancer cells using fucoidan nanoparticle polymer [ 41 ]. Secondary metabolites in Algae Kappaphycus alvarezii shows potential anti-cancer potency in breast cancer [ 42 ].…”

The Correlation between the Level of Physical Activity and the Incidence of Breast Cancer in RSUD Dr. Soetomo Surabaya

“…Based on data from the Global Cancer Observatory (2020), breast cancer cases have a high prevalence in Indonesia (Ng et al, 2023). The incidence of new cases of breast cancer in Indonesia reached 68,858 cases, and the death rate was more than 22 thousand people in 2020 (Hamami et al, 2022). This makes breast cancer one of the first causes of death due to cancer in Indonesia.…”