2017
DOI: 10.1038/s41598-017-09741-w
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Nano-topography Enhances Communication in Neural Cells Networks

Abstract: Neural cells are the smallest building blocks of the central and peripheral nervous systems. Information in neural networks and cell-substrate interactions have been heretofore studied separately. Understanding whether surface nano-topography can direct nerve cells assembly into computational efficient networks may provide new tools and criteria for tissue engineering and regenerative medicine. In this work, we used information theory approaches and functional multi calcium imaging (fMCI) techniques to examine… Show more

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Cited by 54 publications
(67 citation statements)
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References 49 publications
(67 reference statements)
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“…We used the methods reported in references (Onesto et al 2016, Onesto et al 2017 to evaluate the amount of information exchanged by the different grids as a function of the small-world-ness (entropy) of the grids. Information is associated to the probability of an event.…”
Section: Information Transported In the Networkmentioning
confidence: 99%
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“…We used the methods reported in references (Onesto et al 2016, Onesto et al 2017 to evaluate the amount of information exchanged by the different grids as a function of the small-world-ness (entropy) of the grids. Information is associated to the probability of an event.…”
Section: Information Transported In the Networkmentioning
confidence: 99%
“…When the cumulative signal reaches a threshold that can be arbitrarily tuned, the neuron in turn generates a signal that propagates in cascade in the grid. A similar model is called a generalized leaky integrate and fire model (FitzHugh, 1955, de la Rocha andParga, 2005), a more sophisticated evolution of the model in which single computational components are arrayed in systems with a great many of elements -to form functional neuronal networks -has been recently developed by some of the authors of this paper (Onesto et al 2016, Onesto et al 2017, Onesto et al 2018. In a biological interpretation of the scheme, the signal released by the neuron is an action potential, and the sequence and time pattern of action potentials encodes the information transported in the network (Strong et al 1998, Borst andTheunissen 1999, Figure 7.…”
Section: Information Transported In the Networkmentioning
confidence: 99%
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“…14 Micro and nano topographical substrates can actuate the mechano-transduction pathways that regulate stem cell fate by contact guidance through the rearrangement of cytoskeleton alignment, leading to changes in nucleus shape and altering gene expression. 15 Most studies have indicated that nanopatterned surfaces activate cell surface proteins such as integrins, which are responsible for cell surface signal transduction, cluster assembly, and formation of focal adhesion complexes containing vinculin, paxillin, and focal adhesion kinase (FAK), which alter the arrangement and mechanical tension of the cytoskeleton. 16,17 Ultimately, the mechanotransduction pathway activated by mechanical tension changes the nucleus shape and the expression profile of genes involved in stem cell differentiation.…”
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confidence: 99%