Nano-topography and functionalization with the synthetic peptoid GN2-Npm9 as a strategy for antibacterial and biocompatible titanium implants

Gamna, Francesca; Cochis, Andrea; Mojsoska, Biljana; Kumar, Ajay; Rimondini, Lia; Spriano, Silvia

doi:10.1016/j.heliyon.2024.e24246

Cited by 2 publications

(4 citation statements)

References 55 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…coli. In fact, as previously shown, , it must be considered that cells and bacteria are not separate entities in the real clinical scenario, but, on the contrary, they compete to adhere and colonize the same surface, e.g., the newly implanted biomedical device putting in place a sort of “race for the surface” . Accordingly, here hMSCs were seeded onto the mats’ surface and infected with E.…”

Section: Resultsmentioning

confidence: 98%

“…After demonstrating the cytocompatibility and antibacterial activity of the mats, a bacteria−cell coculture assay was used to verify whether the antibacterial effect was targeted to affect pathogens while preserving cells' viability in an environmental competition between hMSCs and E. coli. In fact, as previously shown, 48,65 it must be considered that cells and bacteria are not separate entities in the real clinical scenario, but, on the contrary, they compete to adhere and colonize the same surface, e.g., the newly implanted biomedical device putting in place a sort of "race for the surface". 66 Accordingly, here hMSCs were seeded onto the mats' surface and infected with E. coli that was selected within the tested strains because it was more frequently involved in different types of systemic infections than S. epidermidis and P. aeruginosa.…”

Section: Cytocompatibilitymentioning

confidence: 99%

See 1 more Smart Citation

Highly Cytocompatible Polylactic Acid Based Electrospun Microfibers Loaded with Silver Nanoparticles Generated onto Chestnut Shell Lignin for Targeted Antibacterial Activity and Antioxidant Action

Argenziano,

Viggiano,

Laezza

et al. 2024

ACS Appl. Mater. Interfaces

Self Cite

View full text Add to dashboard Cite

Electrospun (e-spun) fibers are generally regarded as powerful tools for cell growth in tissue regeneration applications, and the possibility of imparting functional properties to these materials represents an increasingly pursued goal. We report herein the preparation of hybrid materials in which an e-spun d,l-polylactic acid matrix, to which chitosan or crystalline nanocellulose was added to improve hydrophilicity, was loaded with different amounts of silver(0) nanoparticles (AgNP) generated onto chestnut shell lignin (CSL) (AgNP@CSL). A solvent-free mechanochemical method was used for efficient (85% of the theoretical value by XRD analysis) Ag(0) production from the reduction of AgNO3 by lignin. For comparison, e-spun fibers containing CSL alone were also prepared. SEM and TEM analyses confirmed the presence of AgNP@CSL (average size 30 nm) on the fibers. Different chemical assays indicated that the AgNP@CSL containing fibers exhibited marked antioxidant properties (EC50 1.6 ± 0.1 mg/mL, DPPH assay), although they were halved with respect to those of the CSL containing fibers, as expected because of the efficient silver ion reduction. All the fibers showed high cytocompatibility toward human mesenchymal stem cells (hMSCs) representative of the self-healing process, and their antibacterial properties were tested against the pathogens Escherichia coli (E. coli), Staphylococcus epidermidis, and Pseudomonas aeruginosa. Finally, competitive surface colonization as simulated by cocultures of hMSC and E. coli showed that AgNP@CSL loaded fibers offered the cells a targeted protection from infection, thus well balancing cytocompatibility and antibacterial properties.

show abstract

Section: Resultsmentioning

confidence: 98%

Section: Cytocompatibilitymentioning

confidence: 99%

Highly Cytocompatible Polylactic Acid Based Electrospun Microfibers Loaded with Silver Nanoparticles Generated onto Chestnut Shell Lignin for Targeted Antibacterial Activity and Antioxidant Action

Argenziano,

Viggiano,

Laezza

et al. 2024

ACS Appl. Mater. Interfaces

Self Cite

View full text Add to dashboard Cite

show abstract

“…The latter could help reduce the risk of infections in medical implants. Particles could be designed with a targeting ability to destroy bacteria and, at the same time, minimize the risk of developing resistance to bacteria ( Cazzola et al, 2023 ; Gamna et al, 2024 ). However, there are disadvantages to consider as well.…”

Section: Epidemiology: Keeping Orthopaedic Disorders In Perspectivementioning

confidence: 99%

“…One must observe such changes in the performance of medical implants. Further studies and developments will need to be done to optimize such surfaces for safety and effectiveness ( Cazzola et al, 2023 ; Gamna et al, 2024 ).…”

Section: Epidemiology: Keeping Orthopaedic Disorders In Perspectivementioning

confidence: 99%

Pioneering nanomedicine in orthopedic treatment care: a review of current research and practices

Liang,

Zhou,

Zhang

et al. 2024

Front. Bioeng. Biotechnol.

View full text Add to dashboard Cite

A developing use of nanotechnology in medicine involves using nanoparticles to administer drugs, genes, biologicals, or other materials to targeted cell types, such as cancer cells. In healthcare, nanotechnology has brought about revolutionary changes in the treatment of various medical and surgical conditions, including in orthopedic. Its clinical applications in surgery range from developing surgical instruments and suture materials to enhancing imaging techniques, targeted drug delivery, visualization methods, and wound healing procedures. Notably, nanotechnology plays a significant role in preventing, diagnosing, and treating orthopedic disorders, which is crucial for patients’ functional rehabilitation. The integration of nanotechnology improves standards of patient care, fuels research endeavors, facilitates clinical trials, and eventually improves the patient’s quality of life. Looking ahead, nanotechnology holds promise for achieving sustained success in numerous surgical disciplines, including orthopedic surgery, in the years to come. This review aims to focus on the application of nanotechnology in orthopedic surgery, highlighting the recent development and future perspective to bridge the bridge for clinical translation.

show abstract

Nano-topography and functionalization with the synthetic peptoid GN2-Npm9 as a strategy for antibacterial and biocompatible titanium implants

Cited by 2 publications

References 55 publications

Highly Cytocompatible Polylactic Acid Based Electrospun Microfibers Loaded with Silver Nanoparticles Generated onto Chestnut Shell Lignin for Targeted Antibacterial Activity and Antioxidant Action

Highly Cytocompatible Polylactic Acid Based Electrospun Microfibers Loaded with Silver Nanoparticles Generated onto Chestnut Shell Lignin for Targeted Antibacterial Activity and Antioxidant Action

Pioneering nanomedicine in orthopedic treatment care: a review of current research and practices

Contact Info

Product

Resources

About