Nano-Therapeutics for the Lung: State-of-the-Art and Future Perspectives

Iyer, Roshni; Hsia, Connie C. W.; Nguyen, Kytai T.

doi:10.2174/1381612821666150923095742

Cited by 59 publications

(36 citation statements)

References 125 publications

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“…Over the years, it has been highlighted that nanoparticles frequently exhibit improved properties for easier translocation across biological barriers as they have the advantages of high surface area/volume ratio and increased mobility, and hence a great interactive potential with the biological surfaces . Nanoparticles also offer the potential to protect the encapsulated molecules from both extracellular and intracellular degradation, resulting in improved intracellular bioavailability . In addition, surface conjugation of specific ligands allows nanoparticles to interact with a particular group of receptors at the cell and tissue surfaces, thereby favourably modifying the intracellular disposition of nanoparticles .…”

Section: Introductionmentioning

confidence: 99%

Overviews on the cellular uptake mechanism of polysaccharide colloidal nanoparticles

Salatin

Khosroushahi

2017

J Cellular Molecular Medi

242

143

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Nanoparticulate drug/gene carriers have gained much attention in the past decades because of their versatile and tunable properties. However, efficacy of the therapeutic agents can be further enhanced using naturally occurring materials‐based nanoparticles. Polysaccharides are an emerging class of biopolymers; therefore, they are generally considered to be safe, non‐toxic, biocompatible and biodegradable. Considering that the target of nanoparticle‐based therapeutic strategies is localization of biomedical agents in subcellular compartments, a detailed understanding of the cellular mechanism involved in the uptake of polysaccharide‐based nanoparticles is essential for safe and efficient therapeutic applications. Uptake of the nanoparticles by the cellular systems occurs with a process known as endocytosis and is influenced by the physicochemical characteristics of nanoparticles such as size, shape and surface chemistry as well as the employed experimental conditions. In this study, we highlight the main endocytosis mechanisms responsible for the cellular uptake of polysaccharide nanoparticles containing drug/gene.

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Section: Introductionmentioning

confidence: 99%

Overviews on the cellular uptake mechanism of polysaccharide colloidal nanoparticles

Salatin

Khosroushahi

2017

J Cellular Molecular Medi

242

143

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“…Despite these attractive advantages, the possible high lung toxicity of drugs, their degradation by lung macrophages, and the risk of drug-induced lung injury limit enthusiasm for inhalation as a route for systemic drug delivery (Iyer et al 2015). Therefore, an ideal drug formulation and inhalation delivery method should be developed.…”

Section: Advantages Of the Inhalation Route And Its Possible Limitationsmentioning

confidence: 99%

New perspectives in nanotherapeutics for chronic respiratory diseases

et al. 2017

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According to the World Health Organization (WHO), hundreds of millions of people of all ages and in all countries suffer from chronic respiratory diseases, with particular negative consequences such as poor health-related quality of life, impaired work productivity, and limitations in the activities of daily living. Chronic obstructive pulmonary disease, asthma, occupational lung diseases (such as silicosis), cystic fibrosis, and pulmonary arterial hypertension are the most common of these diseases, and none of them are curable with current therapies. The advent of nanotechnology holds great therapeutic promise for respiratory conditions, because non-viral vectors are able to overcome the mucus and lung remodeling barriers, increasing pharmacologic and therapeutic potency. It has been demonstrated that the extent of pulmonary nanoparticle uptake depends not only on the physical and chemical features of nanoparticles themselves, but also on the health status of the organism; thus, the huge diversity in nanotechnology could revolutionize medicine, but safety assessment is a challenging task. Within this context, the present review discusses some of the major new perspectives in nanotherapeutics for lung disease and highlights some of the most recent studies in the field.

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“…Pulmonary drug delivery is a non-invasive route used for treating a variety of diseases [2]. The lungs provide an extensive alveolar surface area and a dense capillary network that favors drug absorption and enhances drug biodisponibility, while avoiding most barriers associated with systemic administration [3].…”

Section: Introductionmentioning

confidence: 99%

Proposed molecular model for electrostatic interactions between insulin and chitosan. Nano-complexation and activity in cultured cells

Silva

Martínez

et al. 2018

Colloids and Surfaces A: Physicochemical and Engineering Aspect

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The objective of this contribution was to propose a model that would explain the nanocomplexes formation between Human Recombinant Insulin (I) and a polydisperse Chitosan (CS). Such an objective implied exploring I and CS concentration conditions that allowed the formation of complexes with defined and reproducible submicronic dimensions. I-CS complexes were obtained by mixing I and CS solutions at pH 2 and then increasing the pH up to 6 promoting electrostatic interactions between them. Colloidal stages of I and I-CS nano-complexes formation were characterized by dynamic light scattering (DLS), ζ-potential, solutions flow behavior and absorbance measurements. 1•10-2 %, w/w, of CS allowed covering completely the surface protein aggregates constituting core-shell nano-structures of 200 nm, with a ζ-potential of 17,5 mV. Solution dynamic viscosity results kept relation with different stages of nanocomplexation process. Biological activity of I-CS complexes was studied in 3T3-L1 cultured fibroblast showing a delayed and sustained activity as compared to free insulin. I-CS nano-complexes could be an alternative for developing a new generation of drugs allowing I protection from the hostile conditions of the body and increasing its absorption. These findings have basic and practical impacts as they could be exploited to exert the controlled release of I in therapeutic formulations by using the I-CS nanocomplexes.

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Nano-Therapeutics for the Lung: State-of-the-Art and Future Perspectives

Cited by 59 publications

References 125 publications

Overviews on the cellular uptake mechanism of polysaccharide colloidal nanoparticles

Overviews on the cellular uptake mechanism of polysaccharide colloidal nanoparticles

New perspectives in nanotherapeutics for chronic respiratory diseases

Proposed molecular model for electrostatic interactions between insulin and chitosan. Nano-complexation and activity in cultured cells

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