Nano Textured PEEK Surface for Enhanced Osseointegration

Ouyang, Liping; Chen, Mei‐Ling; Wang, Donghui; Lü, Tao; Wang, Heying; Meng, Fanbin; Yang, Yan; Ma, Jia; Yeung, Kelvin Wai Kwok; Liu, Xuanyong

doi:10.1021/acsbiomaterials.8b01425

Cited by 23 publications

(17 citation statements)

References 70 publications

(102 reference statements)

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“…To generate nanotopographies, magnesium metal is more suitable for surface modification with alkali solution [ 88 ]. For PEEK, nanosturctures can be prepared by argon plasma immersion implantation and hydrogen peroxide treatment [ 89 ]. The etching action by concentrated sulfuric acid on PEEK can generate a porous network structure [ 90 ].…”

Section: Effect Of Implant Surface Nanotopographies On Macrophages An...mentioning

confidence: 99%

Nanotopographical cues for regulation of macrophages and osteoclasts: emerging opportunities for osseointegration

Gao

et al. 2022

J Nanobiotechnol

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Nanotopographical cues of bone implant surface has direct influences on various cell types during the establishment of osseointegration, a prerequisite of implant bear-loading. Given the important roles of monocyte/macrophage lineage cells in bone regeneration and remodeling, the regulation of nanotopographies on macrophages and osteoclasts has arisen considerable attentions recently. However, compared to osteoblastic cells, how nanotopographies regulate macrophages and osteoclasts has not been properly summarized. In this review, the roles and interactions of macrophages, osteoclasts and osteoblasts at different stages of bone healing is firstly presented. Then, the diversity and preparation methods of nanotopographies are summarized. Special attentions are paid to the regulation characterizations of nanotopographies on macrophages polarization and osteoclast differentiation, as well as the focal adhesion-cytoskeleton mediated mechanism. Finally, an outlook is indicated of coordinating nanotopographies, macrophages and osteoclasts to achieve better osseointegration. These comprehensive discussions may not only help to guide the optimization of bone implant surface nanostructures, but also provide an enlightenment to the osteoimmune response to external implant.

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Section: Effect Of Implant Surface Nanotopographies On Macrophages An...mentioning

confidence: 99%

Nanotopographical cues for regulation of macrophages and osteoclasts: emerging opportunities for osseointegration

Gao

et al. 2022

J Nanobiotechnol

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“…In recent years, advances in nanotechnology have promoted novel strategies to increase the bioactivity of PEEK through modification of surface composition and/or morphology, aiming at obtaining implants with antibacterial properties, osteoconduction and improved mechanical strength [ 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 ]. In particular, modifications of surface micro- and nanotexture can control cell differentiation via affecting cell-generated physical forces, thus improving substrate osseointegration [ 21 ]. Methods to modify the PEEK surface mainly include plasma-immersion processes to reach the desired topological structures, with positive effects on cell–substrate interactions [ 22 , 23 ].…”

Section: Introductionmentioning

confidence: 99%

Near-Surface Nanomechanics of Medical-Grade PEEK Measured by Atomic Force Microscopy

et al. 2023

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Detecting subtle changes of surface stiffness at spatial scales and forces relevant to biological processes is crucial for the characterization of biopolymer systems in view of chemical and/or physical surface modification aimed at improving bioactivity and/or mechanical strength. Here, a standard atomic force microscopy setup is operated in nanoindentation mode to quantitatively mapping the near-surface elasticity of semicrystalline polyether ether ketone (PEEK) at room temperature. Remarkably, two localized distributions of moduli at about 0.6 and 0.9 GPa are observed below the plastic threshold of the polymer, at indentation loads in the range of 120–450 nN. This finding is ascribed to the localization of the amorphous and crystalline phases on the free surface of the polymer, detected at an unprecedented level of detail. Our study provides insights to quantitatively characterize complex biopolymer systems on the nanoscale and to guide the optimal design of micro- and nanostructures for advanced biomedical applications.

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“…Concerning the mechanical property of PEEK, the elastic modulus of PEEK is similar to that of cortical bone, which can effectively avoid bone non-union caused by stress shielding. Till now, numerous in vitro studies have confirmed the low cytotoxicity of PEEK to various cells[ 24 , 25 ]. After long-term implantation in the body, it will not release toxic and harmful ions in the follow-up period[ 26 , 27 ].…”

Section: Introductionmentioning

confidence: 99%

Fused Deposition Modeling PEEK Implants for Personalized Surgical Application: From Clinical Need to Biofabrication

Wang¹,

Yang²,

Sun³

et al. 2022

IJB

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Three-dimensional printing (3DP) technology is suitable for manufacturing personalized orthopedic implants for reconstruction surgery. Compared with traditional titanium, polyether-ether-ketone (PEEK) is the ideal material for 3DP orthopedic implants due to its various advantages, including thermoplasticity, thermal stability, high chemical stability, and radiolucency suitable elastic modulus. However, it is challenging to develop a well-designed method and manufacturing technique to meet the clinical needs because it requires elaborate details and interplays with clinical work. Furthermore, establishing surgical standards for new implants requires many clinical cases and an accumulation of surgical experience. Thus, there are few case reports on using 3DP PEEK implants in clinical practice. Herein, we formed a team with a lot of engineers, scientists, and doctors and conducted a series of studies on the 3DP PEEK implants for chest wall reconstruction. First, the thoracic surgeons sort out the specific types of chest wall defects. Then, the engineers designed the shape of the implant and performed finite element analysis for every implant. To meet the clinical needs and mechanical requirements of implants, we developed a new fused deposition modeling technology to make personalized PEEK implants. Overall, the thoracic surgeons have used 114 personalized 3DP PEEK implants to reconstruct the chest wall defect and further established the surgical standards of the implants as part of the Chinese clinical guidelines. The surface modification technique and composite process are developed to overcome the new clinical problems of implant-related complications after surgery. Finally, the major challenges and possible solutions to translating 3DP PEEK implants into a mature and prevalent clinical product are discussed in the paper.

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Nano Textured PEEK Surface for Enhanced Osseointegration

Cited by 23 publications

References 70 publications

Nanotopographical cues for regulation of macrophages and osteoclasts: emerging opportunities for osseointegration

Nanotopographical cues for regulation of macrophages and osteoclasts: emerging opportunities for osseointegration

Near-Surface Nanomechanics of Medical-Grade PEEK Measured by Atomic Force Microscopy

Fused Deposition Modeling PEEK Implants for Personalized Surgical Application: From Clinical Need to Biofabrication

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