Nano-technology for targeted drug delivery to combat antibiotic resistance

Sharma, Abhinay; Arya, Deepak Kumar; Dua, Meenakshi; Chhatwal, Gursharan S.; Johri, Atul Kumar

doi:10.1517/17425247.2012.717927

Cited by 71 publications

(50 citation statements)

References 73 publications

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“…Resistance to antimicrobial agents has become an increasingly important and pressing global problem (8). The antibacterial activity of phenolic components is being increasingly documented (1)(2)(3)(4).…”

Section: Effect Of Encapsulation On Antimicrobial Activity Of Herbal mentioning

confidence: 99%

“…Crude extracts from plants with a history of use in folk medicine have been screened in vitro for antibacterial activity (5). Some researchers have reported synergistic eff ect of naturally occurring fl avonoids and other antibacterial agents against resistant strains of bacteria (8,9). Due to the problem of microbial resistance to antibiotics, att ention is given to biologically active components isolated from plant species commonly used in herbal medicine, as they can be used as antimicrobial preparations (10)(11)(12).…”

Section: Effect Of Encapsulation On Antimicrobial Activity Of Herbal mentioning

confidence: 99%

“…Many studies focus on the development of nanoparticle systems, with dimensions between 1 and 100 nm, for antimicrobial drug delivery (8). Nanoparticles have unique physicochemical properties such as ultrasmall and controllable size, large surface area to mass ratio, high reactivity and functionalizable structure (13).…”

Section: Effect Of Encapsulation On Antimicrobial Activity Of Herbal mentioning

confidence: 99%

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Effect of Encapsulation on Antimicrobial Activity of Herbal Extracts with Lysozyme

Matoušková

Márová

Bokrová

et al. 2016

Food Technol. Biotechnol.

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SummaryResistance of microorganisms to antibiotics has increased. The use of natural components with antimicrobial properties can be of great signifi cance to reduce this problem. The presented work is focused on the study of the eff ect of encapsulation of selected plant and animal antimicrobial substances (herbs, spices, lysozyme and nisin) on their activity and stability. Antimicrobial components were packaged into liposomes and polysaccharide particles (alginate, chitosan and starch). Antimicrobial activity was tested against two Gram-positive (Bacillus subtilis and Micrococcus luteus) and two Gram-negative (Escherichia coli and Serratia marcescens) bacteria. Encapsulation was successful in all types of polysaccharide particles and liposomes. The prepared particles exhibited very good long-term stability, especially in aqueous conditions. Antimicrobial activity was retained in all types of particles. Liposomes with encapsulated herb and spice extracts exhibited very good inhibitory eff ect against all tested bacterial strains. Most of herbal extracts had very good antimicrobial eff ect against the tested Gram-negative bacterial strains, while Gram-positive bacteria were more sensitive to lysozyme particles. Thus, particles with co-encapsulated herbs and lysozyme are more active against diff erent types of bacteria, and more stable and more eff ective during long-term storage. Particles with encapsulated mixture of selected plant extracts and lysozyme could be used as complex antimicrobial preparation with controlled release in the production of food and food supplements, pharmaceutical and cosmetic industries.

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Section: Effect Of Encapsulation On Antimicrobial Activity Of Herbal mentioning

confidence: 99%

Section: Effect Of Encapsulation On Antimicrobial Activity Of Herbal mentioning

confidence: 99%

Section: Effect Of Encapsulation On Antimicrobial Activity Of Herbal mentioning

confidence: 99%

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Effect of Encapsulation on Antimicrobial Activity of Herbal Extracts with Lysozyme

Matoušková

Márová

Bokrová

et al. 2016

Food Technol. Biotechnol.

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“…This highlights the importance of developing new and improved methods of bacterial eradication. However, development of new chemotherapy approaches to combat the rapidly growing resistant strains of bacteria is too slow, threatening our ability to treat infectious diseases in the near future [81].…”

Section: Intracellular Pathogensmentioning

confidence: 99%

A New Era of Pulmonary Delivery of Nano-antimicrobial Therapeutics to Treat Chronic Pulmonary Infections

Merchant

Buckton²,

Taylor³

et al. 2016

CPD

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Pulmonary infections may be fatal especially in immunocompromised patients and patients with underlying pulmonary dysfunction, such as those with cystic fibrosis, chronic obstructive pulmonary disorder, etc. According to the WHO, lower respiratory tract infections ranked first amongst the leading causes of death in 2012, and tuberculosis was included in the top 10 causes of death in low income countries, placing a considerable strain on their economies and healthcare systems. Eradication of lower respiratory infections is arduous, leading to high healthcare costs and requiring higher doses of antibiotics to reach optimal concentrations at the site of pulmonary infection for protracted periods. Hence direct inhalation to the respiratory epithelium has been investigated extensively in the past decade, and seems to be an attractive approach to eradicate and hence overcome this widespread problem. Moreover, engineering inhalation formulations wherein the antibiotics are encapsulated within nanoscale carriers could serve to overcome many of the limitations faced by conventional antibiotics, like difficulty in treating intracellular pathogens such as mycobacteria spp. and salmonella spp., biofilmassociated pathogens like Pseudomonas aeruginosa and Staphylococcus aureus, passage through the sputum associated with disorders like cystic fibrosis and chronic obstructive pulmonary disorder, systemic side effects following oral/parenteral delivery and inadequate concentrations of antibiotic at the site of infection leading to resistance. Encapsulation of antibiotics in nanocarriers may help in providing a protective environment to combat antibiotic degradation, confer controlled-release properties, hence reducing dosing frequency, and may increase uptake via specific and non-specific targeting modalities. Hence nanotechnology combined with direct administration to the airways using commercially available delivery devices, is a highly attractive formulation strategy to eradicate microorganisms from the lower respiratory tract, which might otherwise present opportunities for multi-drug resistance.

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“…Nano-antibiotics are considered a potential treatment option to control infectious diseases and to reduce the overwhelming microbial resistance prevalent nowadays. 11,12 During the past decades, new infections have emerged, and older infections previously thought to be controlled have re-emerged; hence, infectious diseases continue to be one of the greatest health care challenges worldwide. Numbers of multidrug-resistant bacteria are rising steadily, and the current pool of antimicrobial agents is becoming less efficient in combating resistant microbes.…”

mentioning

confidence: 99%

The ability of streptomycin-loaded chitosan-coated magnetic nanocomposites to possess antimicrobial and antituberculosis activities

Zowalaty¹,

Ali²,

Husseiny³

et al. 2015

IJN

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Magnetic nanoparticles (MNPs) were synthesized by the coprecipitation of Fe 2+ and Fe 3+ iron salts in alkali media. MNPs were coated by chitosan (CS) to produce CS-MNPs. Streptomycin (Strep) was loaded onto the surface of CS-MNPs to form a Strep-CS-MNP nanocomposite. MNPs, CS-MNPs, and the nanocomposites were subsequently characterized using X-ray diffraction and were evaluated for their antibacterial activity. The antimicrobial activity of the as-synthesized nanoparticles was evaluated using different Gram-positive and Gram-negative bacteria, as well as Mycobacterium tuberculosis . For the first time, it was found that the nanoparticles showed antimicrobial activities against the tested microorganisms (albeit with a more pronounced effect against Gram-negative than Gram-positive bacteria), and thus, should be further studied as a novel nano-antibiotic for numerous antimicrobial and antituberculosis applications. Moreover, since these nanoparticle bacteria fighters are magnetic, one can easily envision magnetic field direction of these nanoparticles to fight unwanted microorganism presence on demand. Due to the ability of magnetic nanoparticles to increase the sensitivity of imaging modalities (such as magnetic resonance imaging), these novel nanoparticles can also be used to diagnose the presence of such microorganisms. In summary, although requiring further investigation, this study introduces for the first time a new type of magnetic nanoparticle with microorganism theranostic properties as a potential tool to both diagnose and treat diverse microbial and tuberculosis infections.

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Nano-technology for targeted drug delivery to combat antibiotic resistance

Cited by 71 publications

References 73 publications

Effect of Encapsulation on Antimicrobial Activity of Herbal Extracts with Lysozyme

Effect of Encapsulation on Antimicrobial Activity of Herbal Extracts with Lysozyme

A New Era of Pulmonary Delivery of Nano-antimicrobial Therapeutics to Treat Chronic Pulmonary Infections

The ability of streptomycin-loaded chitosan-coated magnetic nanocomposites to possess antimicrobial and antituberculosis activities

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