Nano-structured microparticles for inhalation

Koenneke, Aljoscha; Pourasghar, Marcel; Schneider, Marc

doi:10.1016/b978-0-12-817776-1.00006-7

Cited by 2 publications

(2 citation statements)

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“…The aspherical, cylindrical microparticles were produced using a template-assisted approach [ 41 , 42 ]. This method makes use of the defined shape and dimensions of membrane pores.…”

Section: Methodsmentioning

confidence: 99%

“…These advantages indicate that an aspherical, microparticulate drug delivery system composed of nanoparticles offers an innovative and promising approach for pulmonary applications, overcoming old flaws while merging the best features of different concepts. Therefore, this study aimed to fabricate rod-like, nano-structured microparticles of varying dimensions using a template-assisted approach [ 41 , 42 ] and capillary forces, aiming for efficient particle loading and stabilization. These micro-cylinders were morphologically characterized using an in situ imaging analysis tool (FlowCam ® ) and electron scanning microscopy (SEM).…”

Section: Introductionmentioning

confidence: 99%

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Aspherical, Nano-Structured Drug Delivery System with Tunable Release and Clearance for Pulmonary Applications

Pioch,

Fischer,

Schneider

2024

Pharmaceutics

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Addressing the challenge of efficient drug delivery to the lungs, a nano-structured, microparticulate carrier system with defined and customizable dimensions has been developed. Utilizing a template-assisted approach and capillary forces, particles were rapidly loaded and stabilized. The system employs a biocompatible alginate gel as a stabilizing matrix, facilitating the breakdown of the carrier in body fluids with the subsequent release of its nano-load, while also mitigating long-term accumulation in the lung. Different gel strengths and stabilizing steps were applied, allowing us to tune the release kinetics, as evaluated by a quantitative method based on a flow-imaging system. The micro-cylinders demonstrated superior aerodynamic properties in Next Generation Impactor (NGI) experiments, such as a smaller median aerodynamic diameter (MMAD), while yielding a higher fine particle fraction (FPF) than spherical particles similar in critical dimensions. They exhibited negligible toxicity to a differentiated macrophage cell line (dTHP-1) for up to 24 h of incubation. The kinetics of the cellular uptake by dTHP-1 cells was assessed via fluorescence microscopy, revealing an uptake-rate dependence on the aspect ratio (AR = l/d); cylinders with high AR were phagocytosed more slowly than shorter rods and comparable spherical particles. This indicates that this novel drug delivery system can modulate macrophage uptake and clearance by adjusting its geometric parameters while maintaining optimal aerodynamic properties and featuring a biodegradable stabilizing matrix.

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“…The aspherical, cylindrical microparticles were produced using a template-assisted approach [ 41 , 42 ]. This method makes use of the defined shape and dimensions of membrane pores.…”

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%