Nano-Strategies for Improving the Bioavailability of Inhaled Pharmaceutical Formulations

Xing, Yue; Lü, Peng; Xue, Zhifeng; Liang, Chun-Xia; Zhang, Bing; Kebebe, Dereje; Liu, Hongfei; Liu, Zhidong

doi:10.2174/1389557520666200509235945

Cited by 9 publications

(7 citation statements)

References 138 publications

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“…Several studies have shown that birds, poultry, and fish can ingest nanoparticles, then be absorbed by the digestive system and transferred from the circulatory system to different organs. 38,39 The accumulation of nano-to-micron-sized was detected in the lung.…”

Section: Discussionmentioning

confidence: 99%

Polystyrene microplastics induce autophagy and apoptosis in birds lungs via PTEN/PI3K/AKT/mTOR

Yin

et al. 2022

Environmental Toxicology

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Microplastics (MPs) seriously pollute and potentially threaten human health. Birds are sentinels of environmental pollutants, which respond quickly to contamination events and reveal current environmental exposure. Therefore, birds are good bioindicators for monitoring environmental pollutants. However, the mechanism of lung injury in birds and the role of the PTEN/PI3K/AKT axis are unknown. In this study, broilers treated with different polystyrene microplastics (PS‐MPs) (0, 1, 10, and 100 mg/L) were exposed to drinking water for 6 weeks to analyze the effect of PS‐MPs on lung injury of broilers. The results showed that with the increase of PS‐MPs concentration, malonaldehyde (MDA) content increased, and catalase (CAT) and glutathione (GSH) activity decreased, further leading to oxidative stress. PS‐MPs caused the PI3K/Akt/mTOR pathway to be inhibited by phosphorylation, and autophagy accelerated formation (LC3) and degradation (p62), causing autophagy. In PS‐MPs exposed lung tissues, the expression of Bax/Bcl‐2 and Caspase family increased, and MAPK signaling pathways (p38, ERK, and JNK) showed an increase in phosphorylation level, thus leading to cell apoptosis. Our research showed that PS‐MPs could activate the antioxidant system. The antioxidant system unbalance‐regulated Caspase family, and PTEN/PI3K/AKT pathways initiated apoptosis and autophagy, which in turn led to lung tissue damage in chickens. These results are of great significance to the toxicological study of PS‐MPs and the protection of the ecosystem.

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Section: Discussionmentioning

confidence: 99%

Polystyrene microplastics induce autophagy and apoptosis in birds lungs via PTEN/PI3K/AKT/mTOR

Yin

et al. 2022

Environmental Toxicology

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“…Certain nanoformulations (i.e., dendrimers, polymers, liposomes, nano-emulsions, and micelles) can decrease particle sizes and have been used to increase bioavailability and minimize the adverse effects produced by the ligand(s) they deliver to the tumor site(s) [ 188 ]. The nanoformulations generally have a size range from 10 to 100 nm and can be classified as nanocarriers, no-carrier-added nanosuspensions and polymer-drug conjugates [ 189 ].…”

Section: Various Classes Of Nanomedicinesmentioning

confidence: 99%

Nanotechnology-based delivery systems to overcome drug resistance in cancer

Patel,

Li,

et al. 2024

Medical Review

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Cancer nanomedicine is defined as the application of nanotechnology and nanomaterials for the formulation of cancer therapeutics that can overcome the impediments and restrictions of traditional chemotherapeutics. Multidrug resistance (MDR) in cancer cells can be defined as a decrease or abrogation in the efficacy of anticancer drugs that have different molecular structures and mechanisms of action and is one of the primary causes of therapeutic failure. There have been successes in the development of cancer nanomedicine to overcome MDR; however, relatively few of these formulations have been approved by the United States Food and Drug Administration for the treatment of cancer. This is primarily due to the paucity of knowledge about nanotechnology and the fundamental biology of cancer cells. Here, we discuss the advances, types of nanomedicines, and the challenges regarding the translation of in vitro to in vivo results and their relevance to effective therapies.

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“…The basal layer of the endothelium is referred to as the submucosa, which is rich in blood vessels and, therefore, facilitates the absorption of the vaccine antigens [ 8 ]. On the surface of the nasal cavity, the epithelial cells are tightly connected, forming a special physical barrier that prevents the invasion of antigenic particles, similar to the active defense against pathogenic microorganisms [ 9 ].…”

Section: Nasal Structure and Immune Responsesmentioning

confidence: 99%

Development of Nasal Vaccines and the Associated Challenges

et al. 2022

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Viruses, bacteria, fungi, and several other pathogenic microorganisms usually infect the host via the surface cells of respiratory mucosa. Nasal vaccination could provide a strong mucosal and systemic immunity to combat these infections. The intranasal route of vaccination offers the advantage of easy accessibility over the injection administration. Therefore, nasal immunization is considered a promising strategy for disease prevention, particularly in the case of infectious diseases of the respiratory system. The development of a nasal vaccine, particularly the strategies of adjuvant and antigens design and optimization, enabling rapid induction of protective mucosal and systemic responses against the disease. In recent times, the development of efficacious nasal vaccines with an adequate safety profile has progressed rapidly, with effective handling and overcoming of the challenges encountered during the process. In this context, the present report summarizes the most recent findings regarding the strategies used for developing nasal vaccines as an efficient alternative to conventional vaccines.

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Nano-Strategies for Improving the Bioavailability of Inhaled Pharmaceutical Formulations

Cited by 9 publications

References 138 publications

Polystyrene microplastics induce autophagy and apoptosis in birds lungs via PTEN/PI3K/AKT/mTOR

Polystyrene microplastics induce autophagy and apoptosis in birds lungs via PTEN/PI3K/AKT/mTOR

Nanotechnology-based delivery systems to overcome drug resistance in cancer

Development of Nasal Vaccines and the Associated Challenges

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