Nano-Sized Micelles of Block Copolymers of Methoxy Poly(ethylene glycol)-Poly(ε-caprolactone)-Graft-2-Hydroxyethyl Cellulose for Doxorubicin Delivery

Abstract

The amphiphilic block copolymers methoxy poly(ethylene glycol)-poly(ε-caprolactone) was grafted to 2-hydroxyethyl cellulose to produce the water-soluble copolymers. Doxorubicin loaded nanoparticles were prepared by dialysis method and the sizes of nanoparticles were determined by dynamic light scattering in solution and atomic force microscopes. As results the sizes were detected in a range of 197.4 to 340.7 nm. The in-vitro release of Dox was studied in phosphate and acetate buffered solution at 37 °C. The results showed that 43 and 53% of Dox remained after an incubation period of 7 days. The cytotoxicity of Dox loaded micelles was investigated in two different human MCF-7/wild type and MCF-7/Adriamycin drug resistant cells lines. The Dox-loaded micelles showed reduced cytotoxicity compared to free Dox in MCF-7/wild type and MCF-7/Adriamycin drug resistant cells.

Targeted delivery of doxorubicin to human breast cancers by folate-decorated star-shaped PEG–PCL micelle

“…A similar pattern has been observed in acidic conditions. 1,32 The results could be attributed to the re-protonation (ionization) of the amino group of DOX and the faster degradation of the micelle core at lower pH value. This pH-dependent release profile is of particular interest.…”

“…A drug delivery system using several conventional nanocarriers (i.e., polymeric nanoparticles and polymeric micelles) has received significant attention to deliver drugs to targeting sites. [1][2][3] These nanocarrier systems are accumulated in tumor cells via passive targeting mechanisms called the enhanced permeability and retention (EPR) effect. 4 As one of the most promising nanocarrier systems, self assembled polymeric micelles were widely utilized for drug delivery systems because of the ability to incorporate drugs into the nanosystems, improving bioavailability, solubility, and retention time of drugs and overcoming multiple drug resistance (MDR) effect.…”

Ionic liquids for the preparation of biopolymer materials for drug/gene delivery: a review

“…Due to the extremely poor solubility of cellulose in most aqueous and organic solvents and the difficulty in cellulose processing, most cellulose-based materials can only be prepared from soluble cellulose derivatives such as ethyl cellulose, 181 hydroxypropyl cellulose, 182 and hydroxyethyl cellulose. 183 However, these soluble derivatives could increase the risk of toxicity and the costs of the products. On the other hand, the application of ILs as reaction medium allows the 187 The high reaction efficiency achieved with ILs as media are attributed to their capability to disrupt the biopolymer structure through weakening the inter-and intramolecular hydrogen bonds between biopolymer chains.…”

Cellulose derivatives and graft copolymers as blocks for functional materials

“…The cellulose graft copolymers have a range of potential applications. The self‐assembled micelles from cellulose graft copolymers can be used as carriers for drug and gene controllable delivery . Moreover, cellulose graft copolymers can be used as (bio)sensors, as the raw materials for the preparation of honeycomb microporous films by the ‘breath figure’ approach and for adsorption of heavy mental ions in waste water .…”