Nano-selenium and its nanomedicine applications: a critical review

Hosnedlová, Božena; Kępińska, Marta; Skaličková, Sylvie; Fernandez, Carlos; Ruttkay-Nedecký, Branislav; Peng, Qiuming; Baroň, Mojmí­r; Melčová, Magdalena; Opatřilová, Radka; Zídková, J.; Bjørklund, Geir; Sochor, Jiří­; Kizek, René

doi:10.2147/ijn.s157541

Cited by 448 publications

(307 citation statements)

References 167 publications

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“…Nano-Se can improve the lipid profile which could be closely connected to the protective roles against heat stress. Moreover, the potential role of selenium-coated nanostructures has also been revealed to be effective in the treatment of fatty liver disease, by enhancing the oral bioavailability and strengthening the hypoglycemic action of phytogenesis [16].…”

Section: Discussionmentioning

confidence: 99%

“…Recently, nano-Se has been widely used in poultry nutrition. However, there is a huge concern about the application of the chemical form of nano-Se [16]. The chemical technique can cause hazardous effects for the environment and animals [13,15].…”

Section: Introductionmentioning

confidence: 99%

“…The chemical technique can cause hazardous effects for the environment and animals [13,15]. More recently, biosynthesis of nanoparticles is a new tactic for synthesizing nanoparticles that uses plants and microorganisms which have biomedical uses [16][17][18]. This approach is environmentally friendly, safe, easy to obtain, biocompatible, and cost effective [17].…”

Section: Introductionmentioning

confidence: 99%

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Effects of Dietary Biological or Chemical-Synthesized Nano-Selenium Supplementation on Growing Rabbits Exposed to Thermal Stress

Sheiha

Abdelnour

El‐Hack

et al. 2020

Animals

128

106

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The adverse influences of elevated ambient temperatures during the summer season on the rabbit industry have received increased global attention. Therefore, this study intended to compare the potential effects of nano-selenium (nano-Se) synthesized by biological (BIO) and chemical (CH) methods on growth performance, carcass variables, serum metabolites, and inflammatory cytokines responses of growing rabbits in the summer season. Two hundred and fifty weaned rabbits (males, 35 days of age) were randomly divided into five treatment groups of 50 rabbits each (each group had five replicates with ten male rabbits). Treatment groups were fed a control diet and four controlled diets supplemented with nano-Se synthesized by biological method (BIO25 and BIO50, with a 25 and 50 mg of nano-Se/kg diet, respectively) and chemical method (CH25 and CH50, with a 25 and 50 mg of nano-Se/kg diet, respectively) for eight weeks. During 11 to 13 weeks of age, a gradual enhancement in live body weight (LBW), feed intake (FI) and feed conversion ratio (FCR) was noticed with BIO25 and BIO50 treatments compared to those in the other groups. The carcass percentage was significantly higher (p < 0.01) for animals fed with BIO25 than the other groups. The other organ functions were significantly higher (p < 0.01) in heat-stressed groups compared to that of nano-Se groups. Increasing the level of only BIO from a 25 to a 50 mg/kg diet gave more improvement in the studied parameters. Additionally, the concentrations of serum urea, triglycerides (TG), and glutamyl transferase (GGT) were lower (p < 0.01) in both treated and untreated groups. Likewise, the supplementation with nano-Se (BIO25, BIO50, or CH25) significantly improved the antioxidant indices and inflammatory cytokines responses as indicated from serum metabolites. Based on the study results, nano-Se especially synthesized by the biological method at diet levels of 25 or 50 mg/kg improved the growth performance, kidney and liver functions, carcass traits, antioxidants indices, and inflammatory cytokines of growing rabbits during thermal stress.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Effects of Dietary Biological or Chemical-Synthesized Nano-Selenium Supplementation on Growing Rabbits Exposed to Thermal Stress

Sheiha

Abdelnour

El‐Hack

et al. 2020

Animals

128

106

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“…[ 252 ] Excellent reviews are available on the biomedical applications of nano‐Se. [ 253 ] Interested readers are encouraged to peruse these references for in‐depth information.…”

Section: Metal‐based Nanocompoundsmentioning

confidence: 99%

Metal‐Based Nanomaterials in Biomedical Applications: Antimicrobial Activity and Cytotoxicity Aspects

Makvandi

Wang

Zare

et al. 2020

Adv Funct Materials

473

368

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Microbial colonization on material surfaces is ubiquitous. Biofilms derived from surface-colonized microbes pose serious problems to the society from both an economical perspective and a health concern. Incorporation of antimicrobial nanocompounds within or on the surface of materials, or by coatings, to prevent microbial adhesion or kill the microorganisms after their attachment to biofilms, represents an important strategy in an increasingly challenging field. Over the last decade, many studies have been devoted to preparing meta-based nanomaterials that possess antibacterial, antiviral, and antifungal activities to combat pathogen-related diseases. Herein, an overview on the state-of-the-art antimicrobial nanosized metal-based compounds is provided, including metal and metal oxide nanoparticles as well as transition metal nanosheets. The antimicrobial mechanism of these nanostructures and their biomedical applications such as catheters, implants, medical delivery systems, tissue engineering, and dentistry are discussed. Their properties as well as potential caveats such as cytotoxicity, diminishing efficacy, and induction of antimicrobial resistance of materials incorporating these nanostructures are reviewed to provide a backdrop for future research.

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“…activities. They have been greatly applied as supplements in plants and food and are widely used in nanomedicines due to their low toxicity profiles [109]. They act as detoxifying agents when they contact heavy metals such as mercury, cadmium, and lead and such property has enabled them to guard living organisms against several diseases.…”

Section: Selenium Nanoparticles (Senps)mentioning

confidence: 99%

The Role of Nanotechnology in the Fortification of Plant Nutrients and Improvement of Crop Production

et al. 2019

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Nutrient deficiency in food crops is seriously affecting human health, especially those in the rural areas, and nanotechnology may become the most sustainable approach to alleviating this challenge. There are several ways of fortifying the nutrients in food such as dietary diversification, use of drugs and industrial fortification. However, the affordability and sustainability of these methods have not been completely achieved. Plants absorb nutrients from fertilizers, but most conventional fertilizers have low nutrient use and uptake efficiency. Nanofertilizers are, therefore, engineered to be target oriented and not easily lost. This review surveys the effects of the addition of macro- and nanonutrients to soil, the interaction, and the absorption capability of the plants, the environmental effect and food content of the nutrients. Most reports were obtained from recent works, and they show that plants nutrients could be enriched by applying nanoparticulate nutrients, which are easily absorbed by the plant. Although there are some toxicity issues associated with the use of nanoparticles in crop, biologically synthesized nanoparticles may be preferred for agricultural purposes. This would circumvent the concerns associated with toxicity, in addition to being pollution free. This report, therefore, offers more understanding on the application of nanotechnology in biofortification of plant nutrients and the future possibilities offered by this practice. It also highlights some of the ills associated with the introduction of nanomaterials into the soil for crop’s improvement.

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Nano-selenium and its nanomedicine applications: a critical review

Cited by 448 publications

References 167 publications

Effects of Dietary Biological or Chemical-Synthesized Nano-Selenium Supplementation on Growing Rabbits Exposed to Thermal Stress

Effects of Dietary Biological or Chemical-Synthesized Nano-Selenium Supplementation on Growing Rabbits Exposed to Thermal Stress

Metal‐Based Nanomaterials in Biomedical Applications: Antimicrobial Activity and Cytotoxicity Aspects

The Role of Nanotechnology in the Fortification of Plant Nutrients and Improvement of Crop Production

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