Nano revolution in cardiovascular health: Nanoparticles (NPs) as tiny titans for diagnosis and therapeutics

Abid, Junaid; Khalil, Fatma Mohamed Ameen; Saeed, Sumbul; Khan, Shahid Ullah; Iqbal, Imran; khan, Safir Ullah; Anthony, Stefan; Shahzad, Raheel; Koerniati, Sri; Naz, Farkhanda

doi:10.1016/j.cpcardiol.2024.102466

Cited by 2 publications

(1 citation statement)

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“…Due to their diminutive size, NPs possess not only the capability to traverse cell membranes or the blood–brain barrier for targeted drug delivery but also evade immune surveillance to prolong their retention times within biological tissues. Therefore, NPs have emerged as a promising drug delivery system in medicine, particularly for disease treatment and diagnosis [ 89 ]. Moreover, the advantages of nanoparticles as delivery systems lie in their ability to increase drug loading capacity, enhance stability, exert sustained control over release properties, and facilitate the transport of drugs across cell membranes or biological barriers through precise modulation of their morphology, surface chemistry pharmacokinetics, and release characteristics.…”

Section: Noval Nanotechnology-based Drug Delivery Strategies Of Allicinmentioning

confidence: 99%

Therapeutic potentials of allicin in cardiovascular disease: advances and future directions

Gao,

Wang,

Qin

et al. 2024

Chin Med

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Cardiovascular disease (CVD) remains the predominant cause of mortality and disability worldwide. Against this backdrop, finding effective drugs for the pharmacological treatment of CVD has become one of the most urgent and challenging issues in medical research. Garlic (Allium sativum L.) is one of the oldest plants and is world-renowned for its dietary and medicinal values. Allicin (diallyl thiosulfinate) is one of the primary natural active ingredients in garlic, which has been proven to have powerful cardioprotective effects and mediate various pathological processes related to CVD, such as inflammatory factor secretion, myocardial cell apoptosis, oxidative stress, and more. Therefore, allicin holds a promising application prospect in the treatment of CVD. This review summarized the biological functions of allicin and its potential mechanisms in CVD, including antioxidation, anti-inflammation, and anti-apoptosis effects. Reckoning with these, we delved into recent studies on allicin’s cardioprotective effects concerning various CVDs, such as atherosclerosis, hypertension, myocardial infarction, arrhythmia, cardiac hypertrophy, heart failure, and cardiotoxicity. Further, considering the tremendous advancement in nanomedicine, nanotechnology-based drug delivery systems show promise in addressing limitations of allicin’s clinical applications, including improving its solubility, stability, and bioavailability. Through this review, we hope to provide a reference for further research on allicin in cardioprotection and drug development. Graphical Abstract

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Section: Noval Nanotechnology-based Drug Delivery Strategies Of Allicinmentioning

confidence: 99%