In this study, a new preparation method for nanometer ceramic particles reinforced metal-matrix graded coating by laser multi-layer cladding technology was introduced. The preparation process including following steps: Firstly, a groups of mixture ratio of micro/nanometer covered composite powders are fabricated using a different content of nanometer ceramic particles and micrometer metal-matrix powders by mechanical ball milling; Secondly, the composite powders are suppressed to laser cladding layer by squash presetting; Last, the layers with an increased content of nanometer ceramic particles are laser clad in turn, then a metal-matrix graded coating strengthened by nanometer ceramic particles is prepared. Furthermore, an experiment for fabricating nano-Al2O3 particles reinforced MCrAlY graded coating by laser multi-layer cladding process was carried out. The results show that the laser-clad graded coating has no obvious interface between the different layers with dense and continuous structure. In addition, the microstructure of the laser layer was refined and composed of fine equiaxed grains because of addition of nanometer ceramic particles.