Nano‐Optical Tweezers: Methods and Applications for Trapping Single Molecules and Nanoparticles

Kolbow, Joshua D.; Lindquist, Nathan C.; Ertsgaard, Christopher T.; Yoo, Daehan; Oh, Sang‐Hyun

doi:10.1002/cphc.202100441

Cited by 2 publications

(4 citation statements)

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“…It takes only a few seconds for the first particle to be trapped spontaneously, because of the large size of the array. In total, we observe around 400 trapping events in t = 10 min, assuming a minimum trapping duration of t trap ≥ 1 s, which would, for example, be sufficient to characterize a target with spectroscopic techniques. − Many particles are trapped for longer times; for example, ∼100 beads show a trapping time of t trap > 5 s (Figure b and d, Supporting Movie 1). Typically, we observe 10–15 beads to be trapped in parallel.…”

Section: Resultsmentioning

confidence: 99%

Multiplexed Near-Field Optical Trapping Exploiting Anapole States

Conteduca,

Brunetti,

Barth

et al. 2023

ACS Nano

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Optical tweezers have had a major impact on bioscience research by enabling the study of biological particles with high accuracy. The focus so far has been on trapping individual particles, ranging from the cellular to the molecular level. However, biology is intrinsically heterogeneous; therefore, access to variations within the same population and species is necessary for the rigorous understanding of a biological system. Optical tweezers have demonstrated the ability of trapping multiple targets in parallel; however, the multiplexing capability becomes a challenge when moving toward the nanoscale. Here, we experimentally demonstrate a resonant metasurface that is capable of trapping a high number of nanoparticles in parallel, thereby opening up the field to large-scale multiplexed optical trapping. The unit cell of the metasurface supports an anapole state that generates a strong field enhancement for low-power near-field trapping; importantly, the anapole state is also more angle-tolerant than comparable resonant modes, which allows its excitation with a focused light beam, necessary for generating the required power density and optical forces. We use the anapole state to demonstrate the trapping of 100’s of 100 nm polystyrene beads over a 10 min period, as well as the multiplexed trapping of lipid vesicles with a moderate intensity of <250 μW/μm2. This demonstration will enable studies relating to the heterogeneity of biological systems, such as viruses, extracellular vesicles, and other bioparticles at the nanoscale.

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Section: Resultsmentioning

confidence: 99%

Multiplexed Near-Field Optical Trapping Exploiting Anapole States

Conteduca,

Brunetti,

Barth

et al. 2023

ACS Nano

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“…They have since been developed for other purposes like manipulation of biological molecules and laser atom cooling. Nano-optical tweezers have more recently been developed that can trap single molecules and atoms allowing the bottom-up assembly of systems built from a few atoms [21][22]24]. Light is used to trap or manipulate single molecules or even atoms by exerting a force on them.…”

Section: B Optical Tweezersmentioning

confidence: 99%

“…They can also be used for lithography, assembly of microscopic circuits, spectroscopy, micro-rheology and photonic force microscopy, and lab-ona-chip devices. A current and upcoming application of nanotweezers is for quantum simulation and information processing to create arrays of trapped ions (qubits) for trapped ion quantum computing applications [21][22][23][24][25]. The integration of optical tweezing with holographic tweezing has also allowed increased applications in assembly of macroscopic devices and sorting of macroscopic particles.…”

Section: B Optical Tweezersmentioning

confidence: 99%

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Atomic and Close-to-Atomic Scale Manufacturing: Status and Challenges

Hafeez,

Xie,

Luo

2023

2023 28th International Conference on Automation and Computing (ICAC)

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Next-generation lithography techniques such as Extreme Ultraviolet Lithography have started to reach their physical limits and will not be able to meet the requirements of future Post-Moore Era Integrated Circuit chips that will be based on quantum, photonic, and DNA computing. These future chips and the next generation of quantum products will require sub-10nm and even atomic-scale functional features. Promising candidates for atomic and close-to-atomic scale manufacturing include well-established tip-based techniques such as Scanning Tunnelling Microscopy (STM) and Atomic Force Microscopy (AFM), however, they suffer from severely low throughput, although parallel tips have been suggested to increase the throughput. The integration of these techniques with others such as AFM in Scanning Electron Microscopy has created new hybrid techniques that have greatly enhanced the capabilities of the standalone process. On the other hand, higher throughput techniques like atomic layer etching (ALE) suffer from poor process control and defects despite being promising candidates due to the self-limiting nature of the processes. Studies into laser processing techniques are being investigated to test the feasibility of laser beam-based atomic scale precision manufacturing. Furthermore, the recent progress in quantum simulations has promoted the development of the optical tweezer towards atomic scale manufacturing.

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Nano‐Optical Tweezers: Methods and Applications for Trapping Single Molecules and Nanoparticles

Cited by 2 publications

References 0 publications

Multiplexed Near-Field Optical Trapping Exploiting Anapole States

Multiplexed Near-Field Optical Trapping Exploiting Anapole States

Atomic and Close-to-Atomic Scale Manufacturing: Status and Challenges

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