Nano/Micromotors for Diagnosis and Therapy of Cancer and Infectious Diseases

Yuan, Kaisong; Jiang, Zhengjin; Jurado‐Sánchez, Beatriz; Escarpa, Alberto

doi:10.1002/chem.201903475

Cited by 51 publications

(32 citation statements)

References 127 publications

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“…Many microorganisms possess chemi-cal rotors that enable them to power flagella or cilia, actuated to produce a corkscrew or beading motion leading into locomotion. [69][70][71] Such propulsion mechanism has been the inspiration for rotating synthetic microrobots, [72][73][74] where synthetic helical microstructures, [75][76][77] flexible filaments, [78,79] or tumblers [80,81] rotate in axis to that of a bacterial flagellum. Each individual microrobot is energetically independent of the other microrobots rather than been dragged toward the direction given by the magnetic field (Figure 2a).…”

Section: Robotics Engines At Small Scalesmentioning

confidence: 99%

Medical Micro/Nanorobots in Precision Medicine

et al. 2020

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Advances in medical robots promise to improve modern medicine and the quality of life. Miniaturization of these robotic platforms has led to numerous applications that leverages precision medicine. In this review, the current trends of medical micro and nanorobotics for therapy, surgery, diagnosis, and medical imaging are discussed. The use of micro and nanorobots in precision medicine still faces technical, regulatory, and market challenges for their widespread use in clinical settings. Nevertheless, recent translations from proof of concept to in vivo studies demonstrate their potential toward precision medicine.

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Section: Robotics Engines At Small Scalesmentioning

confidence: 99%

Medical Micro/Nanorobots in Precision Medicine

et al. 2020

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“…To close this section, and to direct readers to sources of information beyond this current review, we list the following excellent review articles on nanomotors for biomedical applications, on the topics of 1) overall overviews, [36,[72][73][74][75] 2) drug delivery/cargo transportation, [32,34,38,40,[76][77][78][79][80][81] 3) diagnosis, [82] 4) sensing, [77][78][79]83] 5) in vivo applications, [34,[84][85][86] 6) surface coating, [87] 7) cancer therapy, [33,37,88,89] 8) biocompatibility, [66] 9) biological barriers/complex environment/entering a cell [39,[90][91][92] and 10) imaging, [90,93,94] as well as on particular types of nanomotors for biomedical application, such as those made of hydrogel [95] or those powered by magnetic fields. [96] This list of review articles-a total of 35 and counting-is by no means comprehensive, and only covers the period of 2013-2020 (see the book by Prof. Joseph Wang [7] for pre-2013 reviews).…”

Section: Nanomotors What and Howmentioning

confidence: 99%

A Journey of Nanomotors for Targeted Cancer Therapy: Principles, Challenges, and a Critical Review of the State‐of‐the‐Art

Wang

Zhou

2020

Adv Healthcare Materials

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A nanomotor is a miniaturized device that converts energy stored in the environment into mechanical motion. The last two decades have witnessed a surge of research interests in the biomedical applications of nanomotors, but little clinical translation. To accelerate this process, targeted cancer therapy is used as an example to describe a “survive, locate, operate, and terminate” (SLOT) mission of a nanomotor, where it must 1) survive in the unfriendly in vivo environment, 2) locate its target as well as be located by human operators, 3) carry out specific operations, and 4) terminate after the mission is completed. Along this journey, the challenges presented to a nanomotor, including to power, navigate, steer, target, release, control, image, and communicate are discussed, and how state‐of‐the‐art nanomotors meet or fall short of these requirements is critically reviewed. These discussions are then condensed into a table for easy reference. In particular, it is argued that chemically powered nanomotors are intrinsically ill‐positioned for targeted cancer therapy, while nanomotors powered by magnetic fields or ultrasound show more promises. Following this argument, a tentative nanomotor design is then presented in the end to conform to the SLOT guideline, and to inspire practical, functional nanorobots that are yet to come.

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“…Diagnosis and curing devices based on nanomaterials are attracting high interest. [ 50 ] While nanomaterials based on metals, metal chalcogenides, metal‐organic frameworks or carbon are commonly reported for applications in biological devices, the application of molecular conductors appears to be limited to bulk TTF‐TCNQ in the field of biosensors. [ 51 ] Nevertheless, only the building molecules of this phase, i.e.…”

Section: Towards Applications Of Molecular Conductors As Nanopartimentioning

confidence: 99%

Nanoparticles of Molecular Conductors and Superconductors: Progress Over the Last Ten Years

Jacob

Faulmann

et al. 2020

Eur J Inorg Chem

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We review conditions for growing molecular conductors and superconductors as nanoparticles, an attractive morphology for integrating them into electronic components or composite materials. Although the one‐dimensional character of these materials does not favor their growth as spheroidal objects, by adding growth controlling molecules to the reaction mixture, we succeeded in growing particles from 2 to 50 nm in size for fourteen systems. The choice of the growth controller depends on the nature of the chemical interactions it can establish with the reactive species to limit growth, and on the chemical or electrochemical synthesis procedure. We show that the chemical nature of the nanoparticles is alike single crystals. Due to resistive boundaries, conducting properties of nanoparticle powders are alike microcrystalline powders. Nevertheless, superconductivity occurs in three of the studied materials. The potential application of these nanomaterials is reported in four fields: composite materials, field‐effect transistors, thermoelectric components and biomedical materials.

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Nano/Micromotors for Diagnosis and Therapy of Cancer and Infectious Diseases

Cited by 51 publications

References 127 publications

Medical Micro/Nanorobots in Precision Medicine

Medical Micro/Nanorobots in Precision Medicine

A Journey of Nanomotors for Targeted Cancer Therapy: Principles, Challenges, and a Critical Review of the State‐of‐the‐Art

Nanoparticles of Molecular Conductors and Superconductors: Progress Over the Last Ten Years

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