Nano-lipoidal carriers of isotretinoin with anti-aging potential: formulation, characterization and biochemical evaluation

Raza, Kaisar; Singh, Bhupinder; Singla, Nitish; Negi, Poonam; Singal, Parteek; Katare, Om Prakash

doi:10.3109/1061186x.2012.761224

Cited by 38 publications

(20 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The film was desiccated overnight to remove traces of chloroform. The obtained thin lipid film was hydrated at 50 ± 1 C and 60 rpm with aqueous phase (distilled water containing 7.0% v/v ethanol) using a rotary film evaporator (Laborota 4011 digital; M/s Heidolph Instruments GmbH & Co. KG, Schwabach, Germany) to obtain a homogenous dispersion of the NLCs (Raza et al, 2013b).…”

Section: Preparation Of Cp-loaded Nlcsmentioning

confidence: 99%

Lipid-based capsaicin-loaded nano-colloidal biocompatible topical carriers with enhanced analgesic potential and decreased dermal irritation

Raza

Shareef²,

Singal

et al. 2014

Journal of Liposome Research

Self Cite

View full text Add to dashboard Cite

Capsaicin (CP), a recent FDA-approved drug for the topical treatment of neuropathic pain, is associated with several side effects like irritation, burning sensation, and erythema, resulting in poor patient compliance. The present study is an attempt to study the effect of CP encasement in nano-lipoidal carriers (NLCs) on skin-transport characteristics, in vivo pharmacological performance, skin compliance, and stability of the finished product. The study also compares two methods of NLC preparation, namely microemulsification and rotary-evaporation for various attributes. The results demonstrated that microemulsion technique produced smaller nanoparticles vis-à-vis the rotary-evaporation method. Out of the various studied solid lipids, NLCs from stearic acid offered smallest size and the highest negative zeta potential. The NLC-gel offered higher skin permeation and skin retention of CP across LACA mice skin as compared with the conventional cream. The analgesic effect was observed to be enhanced substantially than that of the conventional cream when tested on a radiant mouse tail-flick model. The most alarming problems of skin-irritation and redness were successfully taken care by NLC-gel while the mice group receiving conventional cream showed marked changes in the skin histopathology. Besides the enhanced efficacy and decreased skin-irritation, the developed CP-NLCs also found to be stable and rheologically accepted formulation for the treatment of pain-associated disorders.

show abstract

Section: Preparation Of Cp-loaded Nlcsmentioning

confidence: 99%

Lipid-based capsaicin-loaded nano-colloidal biocompatible topical carriers with enhanced analgesic potential and decreased dermal irritation

Raza

Shareef²,

Singal

et al. 2014

Journal of Liposome Research

Self Cite

View full text Add to dashboard Cite

show abstract

“…Isotretinoin has the same unfavourable physicochemical properties [96] for formulation and local side effects as other retinoids. It is widely used as an effective oral medication for severe acne but has significant systemic side-effects including the potential for teratogenicity [97].…”

Section: Targeted Topical Delivery Of Retinoids: Strategies To Impmentioning

confidence: 99%

Targeted Topical Delivery of Retinoids in the Management of Acne Vulgaris: Current Formulations and Novel Delivery Systems

et al. 2019

View full text Add to dashboard Cite

Acne vulgaris is a common inflammatory pilosebaceous condition that affects 80–90% of adolescents. Since the introduction of tretinoin over 40 years ago, topical retinoid products have been a mainstay of acne treatment. The retinoids are very effective in addressing multiple aspects of the acne pathology as they are comedolytic and anti-inflammatory, and do not contribute to antibiotic resistance or microbiome disturbance that can be associated with long-term antibiotic therapies that are a common alternative treatment. However, topical retinoids are associated with skin dryness, erythema and pain, and may exacerbate dermatitis or eczema. Thus, there is a clear need to target delivery of the retinoids to the pilosebaceous units to increase efficacy and minimise side effects in surrounding skin tissue. This paper reviews the current marketed topical retinoid products and the research that has been applied to the development of targeted topical delivery systems of retinoids for acne.

show abstract

“…Aging produces skin thinning and the end result is the formation of wrinkle. Biocompatible nano-lipoidal carriers of isotretinoin showed enhanced photo-aging, improved skin biocompatibility and anti-aging potential [39]. Solid lipid nanoparticles of soy isoflavones showed better penetration through stratum cornea and efficient deposition of soy isoflavones in dermal matrix [40].…”

Section: Nanotechnology In Anti-aging Formulationsmentioning

confidence: 99%

Nanotechnology: A Modern Contraption in Cosmetics and Dermatology

Sharma

Singh

Kanojia

et al. 2018

ACCTRA

View full text Add to dashboard Cite

Background: Nanoscience is the section of science related to the study of minute particles on an atomic or molecular scale, whose size is measured in nanometres. Nanotechnology serves as one of the most capable technologies and accomplished approaches of the 21 st century which is safe and efficacious for novel drug delivery systems. Now, nanotechnology is used widely in the field of cosmetics and dermatology due to the improved properties of the atoms at the nano level. Objectives: This mini-review article has been planned to discuss basic facts regarding nanotechnology as well as various nanotechnology drug delivery systems used in cosmetics and dermatology, applications of nanotechnology and overview of patents published recently in the field of nanocosmetics. The current status of regulatory as well as safety and quality aspects for the use of nanotechnology in cosmetics and dermatology will also be discussed. Discussion: Cosmetics industry is the sixth largest industry among United States patent holders in nanotechnology. Nanotechnology has transfigured the treatment of several skin diseases. Possible applications of nanotechnology in dermatology and cosmetology include sunscreens, moisturizers, anti-aging formulations, anti-sepsis, nails and hair care. The recent studies to date suggest that the nano-cosmeceuticals have no safety issues with skin as well as human health, although the nano-cosmeceuticals are beneficial for human health in a number of ways such as guarding against UV rays which may cause skin cancer. The regulatory bodies had performed an active debate on the potential risk of nano-cosmeceuticals on human health and steps have been taken for thecoordination of regulatory rules.

show abstract

Nano-lipoidal carriers of isotretinoin with anti-aging potential: formulation, characterization and biochemical evaluation

Abstract: The study ratifies enhancement in the efficacy of isotretinoin against photoaging and improved skin biocompatibility after its encasement in novel topical dosage forms.

Cited by 38 publications

References 32 publications

Lipid-based capsaicin-loaded nano-colloidal biocompatible topical carriers with enhanced analgesic potential and decreased dermal irritation

Lipid-based capsaicin-loaded nano-colloidal biocompatible topical carriers with enhanced analgesic potential and decreased dermal irritation

Targeted Topical Delivery of Retinoids in the Management of Acne Vulgaris: Current Formulations and Novel Delivery Systems

Nanotechnology: A Modern Contraption in Cosmetics and Dermatology

Contact Info

Product

Resources

About