Nano-hydroxyapatite use in dentistry: a systematic review

Bordea, Ioana Roxana; Candrea, Sebastian; Alexescu, Gabriela Teodora; Bran, Simion; Băciuţ, Mihaela; Băciuț, Grigore; Lucaciu, Ondine; Dinu, Cristian; Todea, Doina Adina

doi:10.1080/03602532.2020.1758713

Cited by 125 publications

(95 citation statements)

References 41 publications

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“…Nowadays, biomaterials of very different nature are investigated and tested for regeneration of soft tissues, including ceramics, bio-glasses, polymers, hydrogels, and related composites. Among ceramics, calcium phosphates and more recently, calcium silicates emerged as elective materials; particularly hydroxyapatite as nanoparticles or nanostructured bodies, exhibit excellent biocompatibility, bioresorbability, and ability to safely direct stem cell activity, so that, besides applications in the regrow of bones and teeth, nanoapatites are currently investigated for regeneration of the skin, muscles and gums (Zhou and Lee, 2011;Bordea et al, 2020).…”

Section: Introductionmentioning

confidence: 99%

Bioactive Materials for Soft Tissue Repair

Mazzoni

Iaquinta

Lanzillotti

et al. 2021

Front. Bioeng. Biotechnol.

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Over the past decades, age-related pathologies have increased abreast the aging population worldwide. The increased age of the population indicates that new tools, such as biomaterials/scaffolds for damaged tissues, which display high efficiency, effectively and in a limited period of time, for the regeneration of the body's tissue are needed. Indeed, scaffolds can be used as templates for three-dimensional tissue growth in order to promote the tissue healing stimulating the body's own regenerative mechanisms. In tissue engineering, several types of biomaterials are employed, such as bioceramics including calcium phosphates, bioactive glasses, and glass–ceramics. These scaffolds seem to have a high potential as biomaterials in regenerative medicine. In addition, in conjunction with other materials, such as polymers, ceramic scaffolds may be used to manufacture composite scaffolds characterized by high biocompatibility, mechanical efficiency and load-bearing capabilities that render these biomaterials suitable for regenerative medicine applications. Usually, bioceramics have been used to repair hard tissues, such as bone and dental defects. More recently, in the field of soft tissue engineering, this form of scaffold has also shown promising applications. Indeed, soft tissues are continuously exposed to damages, such as burns or mechanical traumas, tumors and degenerative pathology, and, thereby, thousands of people need remedial interventions such as biomaterials-based therapies. It is known that scaffolds can affect the ability to bind, proliferate and differentiate cells similar to those of autologous tissues. Therefore, it is important to investigate the interaction between bioceramics and somatic/stem cells derived from soft tissues in order to promote tissue healing. Biomimetic scaffolds are frequently employed as drug-delivery system using several therapeutic molecules to increase their biological performance, leading to ultimate products with innovative functionalities. This review provides an overview of essential requirements for soft tissue engineering biomaterials. Data on recent progresses of porous bioceramics and composites for tissue repair are also presented.

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Section: Introductionmentioning

confidence: 99%

Bioactive Materials for Soft Tissue Repair

Mazzoni

Iaquinta

Lanzillotti

et al. 2021

Front. Bioeng. Biotechnol.

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“…Calcium and phosphate are essential components of dentin in the form of highly insoluble complex (hydroxyapatite); in the presence of CPP, these minerals remain soluble and biologically available on dentin surfaces (24) . The CPP-ACP-containing paste can also reduce dentin hypersensitivity successfully.…”

Section: Discussionmentioning

confidence: 99%

Comparative evaluation of four different remineralizing agents on dentin surface topography: an invitro study

Wakwak

Elkady

Basha

2021

Egyptian Dental Journal

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This study was designed to evaluate the effect of four remineralizing agents on surface topography of dentin.Materials and methods: 75 Teeth were divided according to the remineralizing agents into five treatment groups (Control C, CPP-ACP A, NovaMin V, n-HA N & NaF F) 15 teeth each. Time of pH cycling periods were divided to (one week (W1), two weeks (W2) and five weeks (W5)Results: Regarding all of pH cycle periods (W1, W2&W5); there was statistically significant difference between mean dentinal tubules diameter values of the control group on one hand and each of A, V, N and F groups on the other hand. However, there was no statistically significance difference between all those remineralizing agents. The N groups showed the lowest mean value of dentinal tubules diameter while the F groups showed the highest mean value of dentinal tubules diameter.Conclusions: Surface topography of dentin is positively affected by the application of remineralizing agents. Increasing the application rate (pH cycling periods) of the remineralizing agents significantly affect the surface topography of dentin.

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“…Nano-HAp is used in various dental domains such as implantology, surgery, direct pulp capping, pulpotomy, dental tissue regeneration, dental drug delivery, periodontology, esthetics, prevention etc. [46,91]. It has a great ability to inhibit both gram-positive and gram-negative bacteria due to which it is used as a coating material for dental implants [91].…”

Section: Dentistrymentioning

confidence: 99%

“…[46,91]. It has a great ability to inhibit both gram-positive and gram-negative bacteria due to which it is used as a coating material for dental implants [91]. HAp-based composite microspheres amoxicillin and erythromycin are released for the treatment of periodontitis [46].…”

Section: Dentistrymentioning

confidence: 99%

An Overview of Synthesis Based Biomedical Applications of Hydroxyapatite Nanomaterials

Bhandari

Bista

Gautam

et al. 2021

J. Nepal Chem. Soc.

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Hydroxyapatite (HAp) is the mineral phase of animal bones embedded in a collagen-containing organic matrix. It is a naturally optimized material for the physical support of the bones. Synthetic Hydroxyapatite based biomaterials, hence, find wide applications in orthopedics, dentistry, and tissue engineering due to their biocompatibility, bioactivity, osteoconductivity, and similar chemical composition to that of HAp present in animal bones. Different physicochemical synthetic methods and natural biogenic sources have been reported for the synthesis of nano-hydroxyapatite. However, particle size, aspect ratio, and the distribution of HAp in biomaterials have significant effects to use as bone substitutes and implants. This paper has summarized some synthetic methods of preparing nano-HAp from different biogenic approaches. Further, it focuses on some facile synthetic routes of preparing nano-HAp with controlled particle size with higher crystallinity and native bone architectures. This review article aims to correlate some simplistic and cost-effective biosynthetic approaches of nano-HAp, their size-dependent properties characterization, and biomedical applications.

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Nano-hydroxyapatite use in dentistry: a systematic review

Cited by 125 publications

References 41 publications

Bioactive Materials for Soft Tissue Repair

Bioactive Materials for Soft Tissue Repair

Comparative evaluation of four different remineralizing agents on dentin surface topography: an invitro study

An Overview of Synthesis Based Biomedical Applications of Hydroxyapatite Nanomaterials

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