Nano-hydroxyapatite and its applications in preventive, restorative and regenerative dentistry: a review of literature

Pepla, Erlind; Besharat, Lait Kostantinos; Palaia, Gaspare; Tenore, Gianluca; Migliau, G

doi:10.11138/ads/2014.5.3.108

Cited by 201 publications

(244 citation statements)

References 12 publications

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“…Previous studies have shown that pastes and toothpastes containing nano-HA have some potential to increase enamel and dentine remineralisation in vitro and in situ [Huang et al, 2011;Najibfard et al, 2011;Tschoppe et al, 2011;Pepla et al, 2014]. However, there are few studies about its effect on dentine de-remineralisation, and most of them analysed the desensitising effect or 504 morphological changes on dentine [Wang et al, 2012;Cao et al, 2013;Orsini et al, 2013;Wang et al, 2014].…”

Section: Discussionmentioning

confidence: 99%

Effect of an Experimental Paste with Hydroxyapatite Nanoparticles and Fluoride on Dental Demineralisation and Remineralisation in situ

et al. 2015

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This study evaluated the effect of an experimental paste containing hydroxyapatite in nanoparticles (nano-HA)/fluoride on dental de-remineralisation in situ. Thirteen subjects took part in this crossover/randomised/double-blind study performed in 4 phases (14 days each). Four sound and 4 pre-demineralised specimens were worn intraorally at each phase corresponding to the following treatments: Nanop Plus (10% HA, 0.2% NaF, nano-HA/fluoride), MI Paste Plus (casein phosphopeptide-amorphous calcium phosphate, 0.2% NaF), F (0.2% NaF) and placebo. Two-hundred and forty enamel and 240 dentine specimens were selected by using surface microhardness; half of them were subjected to pre-demineralisation and the other half remained sound. Sound specimens were further exposed to severe cariogenic challenge (20% sucrose in biofilm) in situ, while pre-demineralised specimens were not. All specimens were exposed to fluoride dentifrice slurry 2 × 1 min/day. Thereafter, the treatments were done for 4 min. The de-remineralisation was quantified by transversal microradiography. The data were statistically analysed by repeated-measures ANOVA/Tukey's tests (p < 0.05). Generally, no huge differences were found among the treatments. However, Nanop Plus was the only treatment able to significantly reduce dentine demineralisation (ΔZ, integrated mineral loss) and to improve enamel remineralisation (ΔΔZ, integrated mineral uptake) compared to placebo. No treatments were able to reduce enamel demineralisation, while for dentine remineralisation all treatments were similarly effective in improving ΔΔZ compared to placebo. Nanop Plus seems to have a positive influence on dental de-remineralisation, which should be further confirmed.

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Section: Discussionmentioning

confidence: 99%

Effect of an Experimental Paste with Hydroxyapatite Nanoparticles and Fluoride on Dental Demineralisation and Remineralisation in situ

et al. 2015

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“…HA is widely used in periodontology and in oral and maxillofacial surgery. Its use in oral implantology, is widely practiced and well-established, as this substance has excellent osteoinductive capacity and improves bone-toimplant integration (15). In this study, we evaluated bone regeneration according to HA manufacturing method in canine alveolar sockets.…”

Section: Discussionmentioning

confidence: 99%

Bone Regeneration of Hydroxyapatite with Granular Form or Porous Scaffold in Canine Alveolar Sockets

Jang

Kim

Han

et al. 2017

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Abstract. This study was undertaken to assess bone regeneration using hydroxyapatite (HA) Hydroxyapatite (HA) is an alloplastic material commonly used as a bone graft substitute due to inherent bioactive properties that support osteo-conduction. However, a weakness of HA-based biomaterials is their slow degradation and absorption in vivo. The granulated form of calcium phosphate ceramics has a regenerative effect within an alveolar bone defect (1). HA is highly crystalline because of the sintering process and has a larger particle size than bone apatite due to grain growth. These large particles are highly resistant to biodegradation in the body, their osteo-conduction is very low, and they cannot be degraded by osteoclasts (2). The porous HA (pHA) scaffold has good bone regeneration in in vivo performance (3-5). This form of material requires proper size and three-dimensional porosity for demonstrating its intrinsic osteo-conductivity and osteogenic potential within limited and exiguous sites such as dental sockets. An HA scaffold with interconnected pore 300 μm in diameter has the most appropriate osteo-conductive capacity (6). Therefore, we hypothesized that HA types and crystallinity influence the rate of bone healing around alveolar sockets.Bone-filling materials undergo radiological evaluation through determination of the bone mineral density (BMD) and information about bone change. Quantitative radiographic evaluation using x-rays is used to assess bone structure and mechanical properties indirectly. In particular, quantitative computed tomography (CT), and peripheral CT are used in humans for monitoring and treatment of metabolic diseases, skeletal status, and osteoporosis (7,8). Micro-CT yields more information about bone mass and microstructure, and is used for studies of bone metabolism in animal models (9-11). Bone formation and mineralization will affect bone strength; mechanical stability depends on the amount and density of bone (12).The bone-regeneration ability of each bone substitute is evaluated compared to bone metabolic disorders model by BMD, percentage bone volume, and other bone structural parameters. Our study evaluated bone substitutes in the alveolar socket of mandibles of beagle dogs to determine BMD levels by CT and bone parameter values by micro-CT at different time points.In this study, osteogenic potential was compared, focusing on alveolar socket healing and restoration using granular HA (gHA) forms and porous HA (pHA) scaffolds. Tissue engineering methods were assessed by manufacturing functional, aesthetic HAs that would not affect adjacent tooth structures. 335

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“…Another in vitro study found that nHA gel had significant potential for enamel remineralization around restoration margins [Juntavee et al, 2018]. The mechanism of nHA biomimetic function is not clear with some researchers suggesting that it promotes remineralization through the creation of a new layer of synthetic enamel around the tooth or by depositing apatite nanoparticles in the enamel defects Pepla et al, 2014]. However, others have proposed that nHA acts as calcium phosphate reservoir maintaining a state of supersaturation with respect to enamel minerals, thereby inhibiting demineralization and enhancing remineralization [Huang et al, 2011].…”

Section: Amelogeninmentioning

confidence: 99%

“…The nano-sized particles can strongly bind to enamel surfaces and with fragments of plaque and bacteria. The small size of the particles that compose nHA considerably increase its surface area for binding as well as allowing it to act as a filler to repair small holes and depressions on the enamel surface [Pepla et al, 2014]. In vitro dynamic pH-cycling experiments have shown that nHA had the potential to remineralize initial enamel lesions with a comparable or even superior efficacy to that of fluoride [Huang et al, 2009[Huang et al, , 2011Najibfard et al, 2011;Tschoppe et al, 2011].…”

Section: Amelogeninmentioning

confidence: 99%

State of the Art Enamel Remineralization Systems: The Next Frontier in Caries Management

2018

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The principles of minimally invasive dentistry clearly dictate the need for clinically effective measures to remineralize early enamel caries lesions. While fluoride-mediated remineralization is the cornerstone of current caries management philosophies, a number of new remineralization strategies have been commercialized or are under development that claim to promote deeper remineralization of lesions, reduce the potential risks associated with high-fluoride oral care products, and facilitate caries control over a lifetime. These non-fluoride remineralizing systems can be broadly categorized into biomimetic enamel regenerative technologies and the approaches that repair caries lesions by enhancing fluoride efficacy. This paper discusses the rationale for non-fluoride remineralization and the mechanism of action, challenges, and evidence behind some of the most promising advances in enamel remineralization therapies.

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Nano-hydroxyapatite and its applications in preventive, restorative and regenerative dentistry: a review of literature

Cited by 201 publications

References 12 publications

Effect of an Experimental Paste with Hydroxyapatite Nanoparticles and Fluoride on Dental Demineralisation and Remineralisation in situ

Effect of an Experimental Paste with Hydroxyapatite Nanoparticles and Fluoride on Dental Demineralisation and Remineralisation in situ

Bone Regeneration of Hydroxyapatite with Granular Form or Porous Scaffold in Canine Alveolar Sockets

State of the Art Enamel Remineralization Systems: The Next Frontier in Caries Management

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