Nano-hybrid electrospun non-woven mats made of wool keratin and hydrotalcites as potential bio-active wound dressings

Giuri, Demetra; Barbalinardo, Marianna; Sotgiu, Giovanna; Zamboni, R.; Nocchetti, Morena; Donnadio, Anna; Corticelli, Franco; Valle, Francesco; Gennari, C.; Selmin, Francesca; Posati, Tamara; Aluigi, Annalisa

doi:10.1039/c8nr10114k

Cited by 40 publications

(28 citation statements)

References 39 publications

(44 reference statements)

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“…This protein can be easily extracted from readily available and low-cost wastes, such as raw wool not suitable for spinning, feathers from butchery, and by-products of the wool textile industry (Aluigi et al, 2007). Regenerated keratin solutions extracted from wool can be easily processed in different biodegradable, biocompatible and non-toxic forms including fibers, capsules, particles, gels, foams, nanofibrous electrospun membranes, and films (Wang et al, 2017;Posati et al, 2018;Giuri et al, 2019). So far keratin based materials have attracted a lot of attention in biomedical applications such as porous scaffolds for tissue engineering, wound healing, and substrates for in vitro studies (Rouse and Van Dyke, 2010).…”

Section: Introductionmentioning

confidence: 99%

Effect of Chemically Engineered Au/Ag Nanorods on the Optical and Mechanical Properties of Keratin Based Films

et al. 2020

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Section: Introductionmentioning

confidence: 99%

Effect of Chemically Engineered Au/Ag Nanorods on the Optical and Mechanical Properties of Keratin Based Films

et al. 2020

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“…Keratin is a fibrous structural protein, present in skin appendages, such as hair, wool, feather, nails, horns, claws, hooves, and in the outer (cornified) layer of epidermis [125,126]. Keratin protects epithelial cells from damage and stress and is insoluble in water and organic solvents.…”

Section: Nature-derived Nanofibers Degradable In the Human Tissuesmentioning

confidence: 99%

“…Properties of electrospun keratin nanofibers were also improved by incorporation of hydrotalcites, intended for delivery of diclofenac. These nanofibers displayed a reduced swelling ratio and a slower degradation profile compared to keratin-based non-woven nanofibrous mats containing free diclofenac [126]. Keratin was also a component of core-shell nanofibers, prepared by coaxial electrospinning of chitosan, PCL and keratin with Aloe vera extracts encapsulated inside the polymer nanofibers.…”

Section: Nature-derived Nanofibers Degradable In the Human Tissuesmentioning

confidence: 99%

Nanofibrous Scaffolds for Skin Tissue Engineering and Wound Healing Based on Nature-Derived Polymers

Bačáková¹,

Pajorová²,

Zikmundová³

et al. 2020

Current and Future Aspects of Nanomedicine

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Nanofibrous scaffolds belong to the most suitable materials for tissue engineering, because they mimic the fibrous component of the natural extracellular matrix. This chapter is focused on the application of nanofibers in skin tissue engineering and wound healing, because the skin is the largest and vitally important organ in the human body. Nanofibrous meshes can serve as substrates for adhesion, growth and differentiation of skin and stem cells, and also as an antimicrobial and moistureretaining barrier. These meshes have been prepared from a wide range of synthetic and nature-derived polymers. This chapter is focused on the use of nature-derived polymers. These polymers have good or limited degradability in the human tissues, which depends on their origin and on the presence of appropriate enzymes in the human tissues. Non-degradable and less-degradable polymers are usually produced in bacteria, fungi, algae, plants or insects, and include, for example, cellulose, dextran, pullulan, alginate, pectin and silk fibroin. Well-degradable polymers are usually components of the extracellular matrix in the human body or at least in other verte brates, and include collagen, elastin, keratin and hyaluronic acid, although some polymers produced by non-vertebrate organisms, such as chitosan or poly(3-hydroxybutyrate-co-3-hydroxyvalerate), are also degradable in the human body.Current and Future Aspects of Nanomedicine 2 microbial infection, and at the same time, they can keep appropriate moisture and gas exchange at the wound site.Nanofibrous scaffolds for skin tissue engineering have been fabricated from a wide range of synthetic and nature-derived polymers, which can be either biostable or degradable within the human body. Biostable synthetic polymers used in nanofiber-based skin regenerative therapies include, for example, polyurethane [2], polydimethylsiloxane [3], polyethylene terephthalate [4], polyethersulfone [5], and also hydrogels such as poly(acrylic acid) (PAA, [6]), poly(methyl methacrylate) (PMMA, [7]), and poly[di(ethylene glycol) methyl ether methacrylate] (PDEGMA, [8]). Degradable synthetic polymers typically include poly(ε-caprolactone) (PCL, [9]) and its copolymers with polylactides (PLCL, [10]), polylactides (PLA, [11]) and their copolymers with polyglycolides (PLGA, [12]), and also so-called auxiliary polymers, such as poly(ethylene glycol) (PEG), poly(ethylene oxide) (PEO, [13]) or poly(vinyl alcohol) (PVA, [14]), which facilitated the electrospinning process and improved the mechanical properties and wettability of the chief polymer. However, the synthetic polymers, although they are well-chemically defined and tailorable, are often bioinert, hydrophobic and thus not promoting cell adhesion, and also not well-adhering to the wound site. Therefore, they need to be combined with other bioactive substances, particularly nature-derived polymers.This chapter is focused on nature-derived polymers used for fabrication of nanofibrous scaffolds for skin tissue engineering and wound healing. The advantages of...

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“…x/n ] mH 2 O where M(II) is a divalent cation such as Mg, Ni, Zn, Cu, or Co, M(III) is a trivalent cation such as Al, Cr, Fe, or Ga, and A n− is an anion of charge n. Recently, hydrotalcites have been successfully dispersed in keratin-based matrices as films and nanofibres in order to obtain functional drug release systems (Posati et al, 2018;Giuri et al, 2019). In the present work, the adsorption the aforementioned keratin-based hybrid systems, in form of porous sponges, have been tested as potential adsorbents for both cationic and anionic species.…”

Section: Introductionmentioning

confidence: 99%

Keratin/Hydrotalcites Hybrid Sponges as Promising Adsorbents for Cationic and Anionic Dyes

Posati

Listwan

Sotgiu

et al. 2020

Front. Bioeng. Biotechnol.

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In this work, keratin sponges were prepared by freeze-drying method and tested for adsorption of Azure A and Methyl Orange dyes. The obtained materials showed a porosity of 99.92% and a mean pore size dimension of about 91 µm. The use of oxidized sucrose with a heating treatment at 150 • C was demonstrated to be a useful crosslinking procedure alternative to the conventional glutaraldehyde. Keratin sponges showed a maximum adsorption capacity of 0.063 and of 0.037 mmol/g for Azure A and Methyl Orange, respectively. The absorption of the cationic dye Azure A onto keratin sponges was better described by Freundlich model while the isotherm adsorption of the anionic Methyl Orange was found to correlate with both Langmuir and Freundlich models. The mean free energies evaluated by using the D-R model indicated a physisorption of Methyl Orange and a chemisorptions of Azure A onto keratin sponges. Finally, the functionalization of keratin sponges with Zn Al hydrotalcites nanoparticles did not affect the adsorption performances of the adsorbent toward the cationic dye Azure A, while it improved those toward the anionic Methyl Orange, increasing the related removal efficiencies from 43 to 96%. Collectively, the reported data indicates that the combination of keratin with hydrotalcites nanoparticles is a good strategy to obtain more functional adsorbent materials of potential interest for water treatment and purification.

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Nano-hybrid electrospun non-woven mats made of wool keratin and hydrotalcites as potential bio-active wound dressings

Abstract: Keratin/hydrotalcites hybrid nanofibers loaded with diclofenac were proposed as a potential drug delivery system and scaffold for cells growth.

Cited by 40 publications

References 39 publications

Effect of Chemically Engineered Au/Ag Nanorods on the Optical and Mechanical Properties of Keratin Based Films

Effect of Chemically Engineered Au/Ag Nanorods on the Optical and Mechanical Properties of Keratin Based Films

Nanofibrous Scaffolds for Skin Tissue Engineering and Wound Healing Based on Nature-Derived Polymers

Keratin/Hydrotalcites Hybrid Sponges as Promising Adsorbents for Cationic and Anionic Dyes

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