Nano‐Gold as Artificial Enzymes: Hidden Talents

Lin, Youhui; Ren, Jinsong; Qu, Xiaogang

doi:10.1002/adma.201400238

Cited by 397 publications

(267 citation statements)

References 90 publications

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“…NP-based enzyme mimetics offer advantages in terms of cost, stability, ease of production and tenability of catalytic activity. Examples of NP systems with enzyme like activity include: nano-gold [16], ferromagnetic materials such as Fe 3 O 4 [17], Co 3 O 4 [18], sheet like-FeS nanostructures, CeO 2 [19], AgM (silver supported metallic nanoparticles), mesoporous silica encapsulated Pt [13]and metallic NPs supported graphene oxide [12,20]. Implementation of these materials in analytical and bioanalytical platforms could rouse development of a new generation of devices with significantly enhanced performances in stability and robustness compared to their enzyme counterparts.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of the oxidase like activity of nanoceria and its application in colorimetric assays

Hayat

Cunningham

Bülbül

et al. 2015

Analytica Chimica Acta

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Nanomaterial-based enzyme mimics have attracted considerable interest in chemical analysis as alternative catalysts to natural enzymes. However, the conditions in which such particles can replace biological catalysts and their selectivity and reactivity profiles are not well defined. This work explored the oxidase like properties of nanoceria particles in the development of colorimetric assays for the detection of dopamine and catechol. Selectivity of the system with respect to several phenolic compounds, the effect of interferences and real sample analysis are discussed. The conditions of use such as buffer composition, selectivity, pH, reaction time and particle type are defined. Detection limits of 1.5 and 0.2μM were obtained with nanoceria for dopamine and catechol. The same assay could be used as a general sensing platform for the detection of other phenolics. However, the sensitivity of the method varies significantly with the particle type, buffer composition, pH and with the structure of the phenolic compound. The results demonstrate that nanoceria particles can be used for the development of cost effective and sensitive methods for the detection of these compounds. However, the selection of the particle system and experimental conditions is critical for achieving high sensitivity. Recommendations are provided on the selection of the particle system and reaction conditions to maximize the oxidase like activity of nanoceria.

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Section: Introductionmentioning

confidence: 99%

Evaluation of the oxidase like activity of nanoceria and its application in colorimetric assays

Hayat

Cunningham

Bülbül

et al. 2015

Analytica Chimica Acta

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“…[16] These enzyme mimetics have great value in practical applications, and therefore become a new frontier in inorganic, materials and analytical chemistry. [17][18][19] In previous studies, ceria nanoparticles (nanoceria) and nanoceria-supported materials have been reported to have multi-enzyme mimetic activities like those of superoxide oxidase, [20,21] catalase [22,23] and oxidase. [24,25] That means nanoceria have enzymatic activities to catalyze the scavenging of reactive oxygen species (ROS).…”

Section: Introductionmentioning

confidence: 99%

Ceria Nanoparticles as Enzyme Mimetics

Wang

Zhang

et al. 2017

Chin. J. Chem.

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In the past decades, enzyme mimetics based on ceria nanoparticles (nanoceria) have been developed as potential substitutes for nature enzymes. The mixed valence states of cerium and the patterns of oxygen vacancies on crystal planes result in different enzyme mimetic activities. In this review we survey the bio-applications of nanoceria-based enzyme mimetics as well as the underlying mechanisms. Factors influencing the enzyme mimetic activities and future perspective of nanoceria-based enzyme mimetics are also addressed.

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“…11,12 AuNPs have attracted the interest of scientists especially in the areas of 13 biosensing, 14 imaging, 15 and drug delivery. 2 Magnetic nanoparticles (MNPs) have generated considerable interest in the scientific world especially in the area of biomedicine and technology, particularly in magnetic storage media, 16 biosensing, 17,18 inks and paints, 19 drug delivery and contrast agents in magnetic resonance imaging.…”

Section: Introductionmentioning

confidence: 99%