Nano-FET-enabled biosensors: Materials perspective and recent advances in North America

Sedki, Mohammed; Shen, Yu; Mulchandani, Ashok

doi:10.1016/j.bios.2020.112941

Cited by 46 publications

(33 citation statements)

References 248 publications

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“…Some 2D oxides are used to build transistor-based biosensors (Bio-FETs). [163,164] Chen et al [165] built quasi-2D In 2 O 3 Bio-FETs, achieving pH sensor with detection limits as low as 0.0005 and glucose sensor with detection limits less than 7 fM. Figure 14a shows the schematic representation of the Bio-FET based on 2D In 2 O 3 and sensing scheme.…”

Section: Biosensorsmentioning

confidence: 99%

2D Oxides for Electronics and Optoelectronics

Liu

Cai³

et al. 2022

Small Science

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In recent years, 2D oxides have attracted considerable attention due to their novel physical properties and excellent stability. With the efforts of researchers, significant progress has been made in the synthesis and electronics and optoelectronics application of 2D oxides. Herein, a systematic review focusing on the preparation of 2D oxides and their applications in electronics and optoelectronics is provided. First, 2D oxides are summarized and classified according to their elements. Then, common preparation methods to synthesize 2D oxides including exfoliation, liquid‐phase synthesis, vapor deposition, surface oxidation of metal, and so on are introduced. Further, the applications of 2D oxides in electronics and optoelectronics are presented. Finally, the current challenges and envisioned development of 2D oxides are commented and prospected.

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Section: Biosensorsmentioning

confidence: 99%

2D Oxides for Electronics and Optoelectronics

Liu

Cai³

et al. 2022

Small Science

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“…First discovered by Iijima in 1991 [98], CNTs can be either metallic or semiconducting depending on chirality and radius. They can also appear as SWCNT or multi-walled nanotubes (a number of concentric SWCNTs of different radii) [99]. This confers a range of possibilities that combines low dimensionality and different electronic properties.…”

Section: Recent Applications Towards Biosensingmentioning

confidence: 99%

Addressing the Theoretical and Experimental Aspects of Low-Dimensional-Materials-Based FET Immunosensors: A Review

et al. 2021

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Electrochemical immunosensors (EI) have been widely investigated in the last several years. Among them, immunosensors based on low-dimensional materials (LDM) stand out, as they could provide a substantial gain in fabricating point-of-care devices, paving the way for fast, precise, and sensitive diagnosis of numerous severe illnesses. The high surface area available in LDMs makes it possible to immobilize a high density of bioreceptors, improving the sensitivity in biorecognition events between antibodies and antigens. If on the one hand, many works present promising results in using LDMs as a sensing material in EIs, on the other hand, very few of them discuss the fundamental interactions involved at the interfaces. Understanding the fundamental Chemistry and Physics of the interactions between the surface of LDMs and the bioreceptors, and how the operating conditions and biorecognition events affect those interactions, is vital when proposing new devices. Here, we present a review of recent works on EIs, focusing on devices that use LDMs (1D and 2D) as the sensing substrate. To do so, we highlight both experimental and theoretical aspects, bringing to light the fundamental aspects of the main interactions occurring at the interfaces and the operating mechanisms in which the detections are based.

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“…Currently, the development of FET biosensors is proceeding rapidly, as many nanomaterials have been applied to construct FET biosensors, including carbon nanotubes, [15] Si nanowires, [16] graphene, [17] and transition metal dichalcogenide films. [18] Benefiting from their advantages of low energy consumption, low cost, and scalability of chip integration, the above FET biosensors have been applied in various detection scenarios, including disease markers, DNA hybridization, bacteria, and viruses.…”

Section: Introductionmentioning

confidence: 99%

Molybdenum disulfide field-effect transistor biosensor for ultrasensitive detection of matrix metallopeptidase 9 (MMP9) gene

Liu

Feng

et al. 2022

Preprint

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Background Biosensors are an emerging field in biomedical diagnostics. In the field of biosensors, field-effect transistor (FET)-based biosensors are widely used in clinical, environmental, and food analysis fields because of their high sensitivity, specificity, and real-time detection. Matrix metallopeptidase 9 (MMP9) is a gene closely related to various diseases, which is considered to have a predictive role in disease diagnosis and qualitative treatment. Methods In this study, an all-solid-state, ultrasensitive FET biosensor based on monolayer molybdenum disulfide (MoS2) was designed and constructed. We synthesized a series of MMP9-targeted probes and obtained the optimal hybridization conditions (including optimal hybridization temperature, hybridization concentration, and hybridization time) for the MoS2 FET biosensors. Results The data show that this MoS2 FET biosensor detects the MMP9 gene at a minimum of 3.86 pM with promising selectivity, specificity, and reproducibility. Conclusion The MoS2 FET biosensor detects the MMP9 gene at a minimum of 3.86 pM with promising selectivity, specificity, and reproducibility. Our work not only provides a potential strategy for the diagnosis and treatment of MMP9-related diseases, but also is helpful for the design of nanodevices, the development of portable diagnostic devices, and the implementation of personalized medicine.

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Nano-FET-enabled biosensors: Materials perspective and recent advances in North America

Cited by 46 publications

References 248 publications

2D Oxides for Electronics and Optoelectronics

2D Oxides for Electronics and Optoelectronics

Addressing the Theoretical and Experimental Aspects of Low-Dimensional-Materials-Based FET Immunosensors: A Review

Molybdenum disulfide field-effect transistor biosensor for ultrasensitive detection of matrix metallopeptidase 9 (MMP9) gene

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