Nano-featured highly interconnective macroporous elastic scaffolds for cardiovascular tissue engineering

Mathew, Juby Alphonsa; Kache, Vikas; Liu, Chao; Tang, Liping; Yang, Jian

doi:10.1109/embsw.2007.4454169

Cited by 2 publications

(1 citation statement)

References 21 publications

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“…Mathew. have developed an improved poly (diol citrates) scaffold fabrication technology by using a secondary porogen, poly (ethylene glycol) dimethyl ether (PEGDM) along with the sieved salts [49]. It was demonstrated that PEGDM may partially participate in the formation of a crosslinked poly (diol citrates) network, thus modulating the degradation and mechanical properties of the resulting poly (diol citrates) scaffolds.…”

Section: Nanoporous Poly (Diol Citrates)mentioning

confidence: 99%

Recent Developments on Citric Acid Derived Biodegradable Elastomers

Tran¹,

Zhang²,

Gyawali³

et al. 2009

BIOMENG

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Biodegradable elastomers have recently found widespread application in many areas of biomedical engineering such as tissue engineering, drug delivery, and bioimaging. In particular, the recent developments in research have led to the creation of citric acid based polymers with enhanced mechanical properties, novel design strategies for crosslinking, nanoporous features, and unique photoluminescent capabilities. The present review will cover the recent patents involving citric acid derived biodegradable biomaterials within the field of biomedical engineering including poly (diol citrates) and their composites, crosslinked urethane-doped polyesters (CUPEs), poly (alkylene maleate citrates) (PAMCs), poly (xylitol-co-citrates) (PXC), and aliphatic biodegradable photoluminescent polymers (BPLPs). The synthesis, development, and applications of these novel polymers will be discussed along with the current trends and future developments in the biomaterials field.

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Section: Nanoporous Poly (Diol Citrates)mentioning

confidence: 99%

Recent Developments on Citric Acid Derived Biodegradable Elastomers

Tran¹,

Zhang²,

Gyawali³

et al. 2009

BIOMENG

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A new generation of sodium chloride porogen for tissue engineering

Tran¹,

Naseri²,

Kolasnikov³

et al. 2011

Biotech and App Biochem

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Porogen leaching is a widely used and simple technique for the creation of porous scaffolds in tissue engineering. Sodium chloride (NaCl) is the most commonly used porogen, but the current grinding and sieving methods generate salt particles with huge size variations and cannot generate porogens in the submicron size range. We have developed a facile method based on the principles of crystallization to precisely control salt crystal sizes down to a few microns within a narrow size distribution. The resulting NaCl crystal size could be controlled through the solution concentration, crystallization temperature, and crystallization time. A reduction in solution temperature, longer crystallization times, and an increase in salt concentration resulted in an increase in NaCl crystal sizes due to the lowered solubility of the salt solution. The nucleation and crystallization technique provides superior control over the resulting NaCl size distribution (13.78 ± 1.18 μm), whereas the traditional grinding and sieving methods produced NaCl porogens 13.89 ± 12.49 μm in size. The resulting NaCl porogens were used to fabricate scaffolds with increased interconnectivity, porous microchanneled scaffolds, and multiphasic vascular grafts. This new generation of salt porogen provides great freedom in designing versatile scaffolds for various tissue-engineering applications.

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Nano-featured highly interconnective macroporous elastic scaffolds for cardiovascular tissue engineering

Cited by 2 publications

References 21 publications

Recent Developments on Citric Acid Derived Biodegradable Elastomers

Recent Developments on Citric Acid Derived Biodegradable Elastomers

A new generation of sodium chloride porogen for tissue engineering

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