Nano-facilitated drug delivery strategies in the treatment of plasmodium infection

Puttappa, Nethravathi; Sureshkumar, Raman; Kuppusamy, Gowthamarajan; Radhakrishnan, Arun

doi:10.1016/j.actatropica.2019.04.020

Cited by 26 publications

(18 citation statements)

References 106 publications

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“…Both goals can be simultaneously achieved through targeted drug delivery strategies that make use of nanocarriers (NCs). 7,8 Many NCs have the capacity to encapsulate different types of drugs and of being functionalized with ligands targeting them to the desired cell type. In addition, if the NCs are loaded with large numbers of drug molecules to be delivered together, their antiparasitic effect will be potentiated and they will have a higher chance to quickly kill the infectious agent.…”

Section: Introductionmentioning

confidence: 99%

Promising nanomaterials in the fight against malaria

et al. 2020

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Section: Introductionmentioning

confidence: 99%

Promising nanomaterials in the fight against malaria

et al. 2020

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“…Nanotechnology-based drug delivery systems are novel tools well placed to improve the efficacy of current antimalarial drugs and overcome their limitations. NCs can be designed to target specific molecules, protect drugs from degradation, prolong blood circulation time, cut down dose frequency, overcome side effects, improve pharmacokinetic (PK) profiles, and increase the overall efficacies of treatments [14,46,79,80]. To achieve these aims, there are three key NC components that need to be carefully assessed in the design phase: the drug loaded, the targeting molecules, and the core delivery system, each of which provides different qualities to the final NC formulation.…”

Section: Antiplasmodial Therapeuticsmentioning

confidence: 99%

Review of the Current Landscape of the Potential of Nanotechnology for Future Malaria Diagnosis, Treatment, and Vaccination Strategies

Guasch-Girbau

Fernàndez‐Busquets

2021

Pharmaceutics

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Malaria eradication has for decades been on the global health agenda, but the causative agents of the disease, several species of the protist parasite Plasmodium, have evolved mechanisms to evade vaccine-induced immunity and to rapidly acquire resistance against all drugs entering clinical use. Because classical antimalarial approaches have consistently failed, new strategies must be explored. One of these is nanomedicine, the application of manipulation and fabrication technology in the range of molecular dimensions between 1 and 100 nm, to the development of new medical solutions. Here we review the current state of the art in malaria diagnosis, prevention, and therapy and how nanotechnology is already having an incipient impact in improving them. In the second half of this review, the next generation of antimalarial drugs currently in the clinical pipeline is presented, with a definition of these drugs’ target product profiles and an assessment of the potential role of nanotechnology in their development. Opinions extracted from interviews with experts in the fields of nanomedicine, clinical malaria, and the economic landscape of the disease are included to offer a wider scope of the current requirements to win the fight against malaria and of how nanoscience can contribute to achieve them.

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“…Nanoformulations have also been investigated for malaria treatment. For this purpose, the activity of conventional antimalarial drugs has been enhanced, especially by encapsulation in liposomes, micelles, polymeric particles, cyclodextrin, and dendrimers [137][138][139][140][141][142]. The first work on the incorporation of traditional antimalarial drugs into liposomes was published in 1989 by Peeters et al [143,144].…”

Section: Formulation Techniquesmentioning

confidence: 99%

Porphyrin Derivative Nanoformulations for Therapy and Antiparasitic Agents

et al. 2020

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Porphyrins and analogous macrocycles exhibit interesting photochemical, catalytic, and luminescence properties demonstrating high potential in the treatment of several diseases. Among them can be highlighted the possibility of application in photodynamic therapy and antimicrobial/antiparasitic PDT, for example, of malaria parasite. However, the low efficiency generally associated with their low solubility in water and bioavailability have precluded biomedical applications. Nanotechnology can provide efficient strategies to enhance bioavailability and incorporate targeted delivery properties to conventional pharmaceuticals, enhancing the effectiveness and reducing the toxicity, thus improving the adhesion to the treatment. In this way, those limitations can be overcome by using two main strategies: (1) Incorporation of hydrophilic substituents into the macrocycle ring while controlling the interaction with biological systems and (2) by including them in nanocarriers and delivery nanosystems. This review will focus on antiparasitic drugs based on porphyrin derivatives developed according to these two strategies, considering their vast and increasing applications befitting the multiple roles of these compounds in nature.

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Nano-facilitated drug delivery strategies in the treatment of plasmodium infection

Cited by 26 publications

References 106 publications

Promising nanomaterials in the fight against malaria

Promising nanomaterials in the fight against malaria

Review of the Current Landscape of the Potential of Nanotechnology for Future Malaria Diagnosis, Treatment, and Vaccination Strategies

Porphyrin Derivative Nanoformulations for Therapy and Antiparasitic Agents

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