“Nano effects”: a review on nanoparticle-induced multifarious systemic effects on cancer theranostic applications

Ravichandran, Gaythri; Yadav, Dokkari Nagalaxmi; Murugappan, Sivasubramanian; Sankaranarayanan, Sri Amruthaa; Revi, Neeraja; Rengan, Aravind Kumar

doi:10.1039/d2ma00784c

Cited by 3 publications

(1 citation statement)

References 112 publications

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“…Their small size allows them to reach the target site directly through a pathophysiological phenomenon called the enhanced permeability and retention effect (EPR), or through the surface receptors. The advantages of these nanoparticles include increased dosage efficacy, higher bioavailability, stealth nature, and minimal side effects of the chemotherapeutic drugs owing to the targeted delivery. − …”

Section: Introductionmentioning

confidence: 99%

Advances in Peptide-Decorated Targeted Drug Delivery: Exploring Therapeutic Potential and Nanocarrier Strategies

Buddhiraju,

Yadav,

Dey

et al. 2023

ACS Appl. Bio Mater.

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Peptides are ideal biologicals for targeted drug delivery and have also been increasingly employed as theranostic tools in treating various diseases, including cancer, with minimal or no side effects. Owing to their receptor-specificity, peptidemediated drug delivery aids in targeted drug delivery with better pharmacological biodistribution. Nanostructured self-assembled peptides and peptide−drug conjugates demonstrate enhanced stability and performance and captivating biological effects in comparison with conventional peptides. Moreover, they serve as valuable tools for establishing interfaces between drug carriers and biological systems, enabling the traversal of multiple biological barriers encountered by peptide−drug conjugates on their journeys to their intended targets. Peptide-based drugs play a pivotal role in the field of medicine and hold great promise for addressing a wide range of complex diseases such as cancer and autoimmune disorders. Nanotechnology has revolutionized the fields of medicine, biomedical engineering, biotechnology, and engineering sciences over the past two decades. With the help of nanotechnology, better delivery of peptides to the target site could be achieved by exploiting the small size, increased surface area, and passive targeting ability of the nanocarrier. Furthermore, nanocarriers also ensure safe delivery of the peptide moieties to the target site, protecting them from degradation. Nanobased peptide delivery systems would be of significant importance in the near future for the successful targeted and efficient delivery of peptides. This review focuses on peptide−drug conjugates and nanoparticle-mediated self-assembled peptide delivery systems in cancer therapeutics.

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Section: Introductionmentioning

confidence: 99%

Advances in Peptide-Decorated Targeted Drug Delivery: Exploring Therapeutic Potential and Nanocarrier Strategies

Buddhiraju,

Yadav,

Dey

et al. 2023

ACS Appl. Bio Mater.

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Diatom-derived extracellular polymeric substances form eco-corona and enhance stability of silver nanoparticles

Gasco,

Worms,

Kantarciyan

et al. 2024

Environ. Sci.: Nano

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Photodynamic therapy with methylene blue and chlorin e6 photosensitizers: study on Ehrlich carcinoma mice model

Pominova,

Ryabova,

Skobeltsin

et al. 2024

Biomedical photonics

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Hypoxia negatively affcts the effctiveness of all types of anticancer therapy, in particular photodynamic therapy (PDT). In this regard, various approaches to overcome the limitations associated with hypoxia are widely discussed in the literature, one of them is the use of photosensitizers (PS) operating through the fist mechanism of the photodynamic reaction, such as methylene blue (MB). Previously, we have demonstrated that MB can have a positive effect on tumor oxygenation. In this work, we investigated the photodynamic activity of MB and a combination of MB with chlorin e6 on a tumor in vivo using a model of Ehrlich carcinoma. PDT was studied with the joint and separate administration of chlorin e6 and MB. The accumulation and localization of MB and its combination with chlorin e6 in vivo was assessed using video ˛uorescence and spectroscopic methods, and the effect of laser exposure on accumulation was analyzed. After the PDT with chlorin e6, MB and a combination of MB with chlorin e6, a good therapeutic effect and a decrease in the tumor growth rate were observed compared to the control, especially in groups with PDT with MB and with the simultaneous administration of chlorin e6 and MB. The level of tumor oxygenation on days 3 and 5 after PDT was higher for groups with irradiation, the highest oxygenation on the 5th day after PDT was observed in the group with PDT only with MB. Phasor diagrams of tumors after PDT show a deviation from the metabolic trajectory and a shift towards a longer lifetimes compared to the control tumor, which indicates the presence of lipid peroxidation products. Thus, tumor regression after PDT is associated with the direct destruction of tumor cells under the in˛uence of reactive oxygen species formed during PDT. Thus, the effectiveness of PDT with the combined use of MB and chlorin e6 has been demonstrated, and the main mechanisms of the antitumor effect of the combination of these PS have been studied.

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“Nano effects”: a review on nanoparticle-induced multifarious systemic effects on cancer theranostic applications

Abstract: The advent of nanotechnology has broadened the scope of technological advances in both medical and industrial applications. Nanotechnology had paved the way to cancer diagnosis and therapy with the conceptual...

Cited by 3 publications

References 112 publications

Advances in Peptide-Decorated Targeted Drug Delivery: Exploring Therapeutic Potential and Nanocarrier Strategies

Advances in Peptide-Decorated Targeted Drug Delivery: Exploring Therapeutic Potential and Nanocarrier Strategies

Diatom-derived extracellular polymeric substances form eco-corona and enhance stability of silver nanoparticles

Photodynamic therapy with methylene blue and chlorin e6 photosensitizers: study on Ehrlich carcinoma mice model

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