Nano Drugs for Curing Malaria

Gnanadesigan, Murugesan; Nandagopalan, V.; Kapildev, Gnanajothi; Gundappa, Mallikarjun

doi:10.1016/b978-0-12-814029-1.00016-8

Cited by 6 publications

(11 citation statements)

References 66 publications

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“…It used PNs functionalized with the Fc fragment of IgG to target neonatal Fc receptor (FcRn) through an FcRn-mediated transcytosis mechanism so the PNs can finally overstep the intestinal epithelium. Valuable information that may be of interest to the reader have also been reviewed elsewhere regarding nanotherapeutics of leishmaniasis [ 120 , 236 , 237 ], tuberculosis [ 238 , 239 , 240 , 241 , 242 ], viral infections [ 243 , 244 ], HIV [ 245 , 246 , 247 , 248 , 249 ], malaria [ 118 , 250 , 251 , 252 ], infectious diseases [ 4 , 45 , 66 , 253 ], intracellular delivery [ 59 , 60 , 64 , 83 , 254 , 255 ], bacterial pathogens [ 46 , 192 , 256 , 257 , 258 , 259 ] and stimuli-responsive systems [ 15 , 58 , 260 , 261 , 262 ].…”

Section: Recent Advances Of Pns In the Treatment Of Intracellular mentioning

confidence: 99%

Recent Advances in Polymeric Nanoparticle-Encapsulated Drugs against Intracellular Infections

2020

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Polymeric nanocarriers (PNs) have demonstrated to be a promising alternative to treat intracellular infections. They have outstanding performance in delivering antimicrobials intracellularly to reach an adequate dose level and improve their therapeutic efficacy. PNs offer opportunities for preventing unwanted drug interactions and degradation before reaching the target cell of tissue and thus decreasing the development of resistance in microorganisms. The use of PNs has the potential to reduce the dose and adverse side effects, providing better efficiency and effectiveness of therapeutic regimens, especially in drugs having high toxicity, low solubility in the physiological environment and low bioavailability. This review provides an overview of nanoparticles made of different polymeric precursors and the main methodologies to nanofabricate platforms of tuned physicochemical and morphological properties and surface chemistry for controlled release of antimicrobials in the target. It highlights the versatility of these nanosystems and their challenges and opportunities to deliver antimicrobial drugs to treat intracellular infections and mentions nanotoxicology aspects and future outlooks.

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Section: Recent Advances Of Pns In the Treatment Of Intracellular mentioning

confidence: 99%

Recent Advances in Polymeric Nanoparticle-Encapsulated Drugs against Intracellular Infections

2020

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“…Aiming at a more bioinspired choice of the organic phase, we also tested squalene, a natural compound which is extracted either from shark liver oil or vegetable oil. Squalene, a 30-carbon atom triterpene, is a highly viscous liquid which has been reported to stabilize W/O emulsion [ 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 ].…”

Section: Resultsmentioning

confidence: 99%

“…Indeed, it appears that Brownian motion is able to overcome the gravity forces that drive the system separation through creaming and sedimentation. In addition to their high kinetic stability, another important feature is the wide surface area providing better drug bioavailability [ 15 ].…”

Section: Introductionmentioning

confidence: 99%

Bioinspired Nanoemulsions Stabilized by Phosphoethanolamine and Phosphoglycerol Lipids

et al. 2020

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Water-in-oil (W/O) nanoemulsions stabilized by phospholipids (PLs) are increasingly exploited in a wide spectrum of applications, from pharmaceuticals to food and cosmetic formulations. In this work, we report the design and optimization of an innovative emulsion based on a mixture of phosphoethanolamine (PE) and phosphoglycerol (PG) PLs, inspired by the composition of the inner leaflet of a bacterial outer membrane. Using the natural oil squalene as the continuous organic phase, no additional emulsion stabilizer is needed. On the other hand, a small amount of Span 80 is required when dodecane is used. The obtained nanoemulsions are stable for at least two hours, thus allowing the droplet size and distribution to be characterized by Dynamic Light Scattering (DLS) and the lipid layer structure and dynamics to be analyzed by Electron Paramagnetic Resonance (EPR) spectroscopy. The results indicate that squalene shallowly intercalates among the lipid tail termini, being unable to deeply penetrate the adsorbed lipid monolayer. The altered lipid dynamics are proposed to be the reason for the enhanced emulsion stability, this paving the way to future implementations and possible applications.

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“…Cerebral malaria is a notorious and malignant parasitic disease that has caused a major percentage of morbidity. According to the World Health Organization (WHO), it causes ∼228 million new infections and almost 450,000 deaths worldwide per year. − Although huge numbers of strategies and approaches have been taken into consideration to combat it, today it remains a global health burden − (Figure ). Malaria is caused by the transmission of Plasmodium species, Plasmodium vivax (most common), Plasmodium falciparum (most lethal species), Plasmodium malariae (less harmful), and Plasmodium ovale , which belongs to the Apicomplexa phylum .…”

Section: Introductionmentioning

confidence: 99%

“…Free drug dihydroartemisinin shows low bioavailability, short half-life, and low stability , and is not available in blood for a prolonged time. To overcome these predicaments, researchers are trying to develop nanoparticle based therapeutic models; ,− however finding suitable nanoparticles to target the infected RBCs is the utmost challenge. Among different forms of carriers, polymeric nanocarriers nowadays exhibit the most promising results for treatment.…”

Section: Introductionmentioning

confidence: 99%

Polymeric Nanoparticle Based Diagnosis and Nanomedicine for Treatment and Development of Vaccines for Cerebral Malaria: A Review on Recent Advancement

Patra

Singh

Wasnik

et al. 2021

ACS Appl. Bio Mater.

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Cerebral malaria occurs due to Plasmodium falciparum infection, which causes 228 million infections and 450,000 deaths worldwide every year. African people are mostly affected with nearly 91% cases, of which 86% are pregnant women and infants. India and Brazil are the other two countries severely suffering from malaria endemicity. Commonly used drugs have severe side effects, and unfortunately no suitable vaccine is available in the market today. In this line, this review is focused on polymeric nanomaterials and nanocapsules that can be used for the development of effective diagnostic strategies, nanomedicines, and vaccines in the management of cerebral malaria. Further, this review will help scientists and medical professionals by updating the status on the development stages of polymeric nanoparticle based diagnostics, nanomedicines, and vaccines and strategies to eradicate cerebral malaria. In addition to this, the predominant focus of this review is antimalarial agents based on polymer nanomedicines that are currently in the preclinical and clinical trial stages, and potential developments are suggested as well. This review further will have an important social and commercial impact worldwide for the development of polymeric nanomedicines and strategies for the treatment of cerebral malaria.

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Nano Drugs for Curing Malaria

Cited by 6 publications

References 66 publications

Recent Advances in Polymeric Nanoparticle-Encapsulated Drugs against Intracellular Infections

Recent Advances in Polymeric Nanoparticle-Encapsulated Drugs against Intracellular Infections

Bioinspired Nanoemulsions Stabilized by Phosphoethanolamine and Phosphoglycerol Lipids

Polymeric Nanoparticle Based Diagnosis and Nanomedicine for Treatment and Development of Vaccines for Cerebral Malaria: A Review on Recent Advancement

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