Nano-drug delivery system with enhanced tumour penetration and layered anti-tumour efficacy

Zhang, Nan; Feng, Nannan; Xin, Xiangying; Zhang, Junwei; Wu, Deqiao; Jiang, Qianqian; Yu, Tong; Gao, Ming; Zhao, Siyuan; Yang, Hui; Tian, Qingfeng

doi:10.1016/j.nano.2022.102592

Cited by 7 publications

(3 citation statements)

References 35 publications

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“…In accordance with eqn (1) and (2), the DOX loading capacity (LC) and entrapment efficiency (EE) of PC-LDHs and ZIF-8@LDHs core–shell structures were successfully calculated. 34 Table 1 demonstrated that the LC and EE of ZIF-8@LDHs core–shell structures were marginally lower than those of PC-LDHs while the aqueous concentration of DOX was 1 mg mL −1 and weight ratio of carriers to DOX was 4 : 1. This agrees with previous thermogravimetric results.…”

Section: Resultsmentioning

confidence: 99%

Facile synthesis of layered double hydroxide nanosheets assembled porous structures for efficient drug delivery

Wang

Liao

et al. 2023

RSC Adv.

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Section: Resultsmentioning

confidence: 99%

Facile synthesis of layered double hydroxide nanosheets assembled porous structures for efficient drug delivery

Wang

Liao

et al. 2023

RSC Adv.

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“…[168][169][170] Compared to conventional drug delivery methods, nanomedicine primarily emphasizes targeted drug delivery, supporting effective treatments for various infectious diseases, cancers, diabetes, and neurodegenerative disorders such as Alzheimer's disease. 171,172 Several successful nanocarriers, including dendrimers, nanoparticles, liposomes, and carbon nanotubes, have been commercialized. These carriers achieve precise targeting and rapid accumulation at the site of action without reliance on any biological system intervention.…”

Section: Latest Research Developments and Case Studiesmentioning

confidence: 99%

Advances in Nanotechnology for Enhancing the Solubility and Bioavailability of Poorly Soluble Drugs

Liu,

Liang,

Yuhong

et al. 2024

DDDT

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This manuscript offers a comprehensive overview of nanotechnology’s impact on the solubility and bioavailability of poorly soluble drugs, with a focus on BCS Class II and IV drugs. We explore various nanoscale drug delivery systems (NDDSs), including lipid-based, polymer-based, nanoemulsions, nanogels, and inorganic carriers. These systems offer improved drug efficacy, targeting, and reduced side effects. Emphasizing the crucial role of nanoparticle size and surface modifications, the review discusses the advancements in NDDSs for enhanced therapeutic outcomes. Challenges such as production cost and safety are acknowledged, yet the potential of NDDSs in transforming drug delivery methods is highlighted. This contribution underscores the importance of nanotechnology in pharmaceutical engineering, suggesting it as a significant advancement for medical applications and patient care.

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“…Nanoparticles with different surface properties can be prepared by adjusting the ratio of different components in the carrier material as well as the ratio of drug to carrier while optimizing the drug loading and encapsulation rate, with a higher loading capacity favoring a better therapeutic effect. Passive targeting is achieved by modulating the size and surface properties of nanoparticles to promote their selective accumulation in tumors through the EPR effect [22]. Active targeting can be achieved by modifying nanomaterials with high-a nity ligands, such as HA [23], folic acid [24], and mannose [25].…”

Section: Introductionmentioning

confidence: 99%

Preparation and Anti-Triple-Negative Breast Cancer Cell Effect of a Nanoparticle for the Codelivery of Paclitaxel and Gemcitabine

Yang

Fan

Zhang

et al. 2023

Preprint

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Amphiphilic polymers (HA-ANI) were prepared by grafting hyaluronic acid (HA) and 6-(2-nitroimidazole)hexylamine (ANI) and then self-assemble in water to form nanoparticles (NPs) that could be loaded with paclitaxel (PTX) and gemcitabine (GEM) by dialysis. Infrared spectroscopy and 1H-NMR indicated the successful synthesis of HA-ANI. Three different ratios of NPs were prepared by adjusting the ratios of hydrophilic and hydrophobic materials, and the particle size decreased as the ratio of hydrophilic materials increased. When HA:ANI=2.0:1, the nanoparticles had the smallest size distribution, good stability and near spherical shape and had high drug loading and encapsulation rates. In vitro release experiments revealed that NADPH could accelerate the drug release from NPs. Cellular uptake rate reached 86.50% at 6 h. The toxic effect of dual drug-loaded nanoparticles (P/G NPs) on MDA-MB-231 cells at 48 h was stronger than that of the free drug. The AO/EB double-staining assay revealed that a large number of late apoptotic cells appeared in the P/G NPs group, and the degree of cell damage was significantly stronger than that of the free drug group. In the cell migration assay, the 24 h-cell migration rate of the P/G NPs group was 5.99%, which was much lower than that of the free group (13.87% and 17.00%). In conclusion, MDA-MB-231 cells could effectively take up P/G NPs, while the introduction of the nano-codelivery system could significantly enhance the toxicity of the drug to MDA-MB-231 cells as well as the migration inhibition effect.

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Nano-drug delivery system with enhanced tumour penetration and layered anti-tumour efficacy

Cited by 7 publications

References 35 publications

Facile synthesis of layered double hydroxide nanosheets assembled porous structures for efficient drug delivery

Facile synthesis of layered double hydroxide nanosheets assembled porous structures for efficient drug delivery

Advances in Nanotechnology for Enhancing the Solubility and Bioavailability of Poorly Soluble Drugs

Preparation and Anti-Triple-Negative Breast Cancer Cell Effect of a Nanoparticle for the Codelivery of Paclitaxel and Gemcitabine

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