Abstract:Understanding the conformational ensemble of an intrinsically disordered protein (IDP) is of great interest due to its relevance to important intracellular functions and diseases. We have recently shown that the polymer scaling exponent characterizing the dependence of protein size on chain length is a crucial factor as it strongly correlates with liquid-liquid phase behavior of an IDP. Previously, sequence properties from charged amino acids, including both fraction of positive/negative charges and charge pat… Show more
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.