Nano-delivery to the lung - by inhalation or other routes and why nano when micro is largely sufficient?

Forest, Valérie; Pourchez, Jérémie

doi:10.1016/j.addr.2022.114173

Cited by 59 publications

(57 citation statements)

References 191 publications

(382 reference statements)

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“…Upon activation of the valve, an abrupt decrease in external pressure triggers the rapid evaporation of the propellant, facilitating aerosolization, and subsequently drug delivery. However, it is worth noting that the non-polar solvent propellants primarily employed as dispersion media for APIs may not be suitable for most nanomedicines with polar surface characteristics, 41 which may cause the serious instability of nanomedicines. DPIs represent the only solid-state pulmonary delivery formulation in which drugs are loaded in solid-state particles to ensure a high drug loading and stability, enabling the delivery of micro-sized particles to lung lesions.…”

Section: Nanomedicines For Targeted Pulmonary Delivery and Treatment ...mentioning

confidence: 99%

Nanomedicines for targeted pulmonary delivery: receptor-mediated strategy and alternatives

Wang,

Zhong,

Huang

et al. 2024

Nanoscale

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Section: Nanomedicines For Targeted Pulmonary Delivery and Treatment ...mentioning

confidence: 99%

Nanomedicines for targeted pulmonary delivery: receptor-mediated strategy and alternatives

Wang,

Zhong,

Huang

et al. 2024

Nanoscale

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“…The epithelial cells are tightly connected by intercellular junctions called tight junctions. Nanoparticles can pass the respiratory epithelia by two different pathways: through tight junctions between the cells or transcellularly by endocytosis [ 48 ].…”

Section: Nanoparticles For Inhaled Vaccinesmentioning

confidence: 99%

Polymeric Nanoparticles for Inhaled Vaccines

et al. 2022

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Many recent studies focus on the pulmonary delivery of vaccines as it is needle-free, safe, and effective. Inhaled vaccines enhance systemic and mucosal immunization but still faces many limitations that can be resolved using polymeric nanoparticles (PNPs). This review focuses on the use of properties of PNPs, specifically chitosan and PLGA to be used in the delivery of vaccines by inhalation. It also aims to highlight that PNPs have adjuvant properties by themselves that induce cellular and humeral immunogenicity. Further, different factors influence the behavior of PNP in vivo such as size, morphology, and charge are discussed. Finally, some of the primary challenges facing PNPs are reviewed including formulation instability, reproducibility, device-related factors, patient-related factors, and industrial-level scale-up. Herein, the most important variables of PNPs that shall be defined in any PNPs to be used for pulmonary delivery are defined. Further, this study focuses on the most popular polymers used for this purpose.

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“…Ligand receptor complex can be greatly selective in this type of targeting by giving the accurate way to targeted site deliv ery. Moreover, nanoparticles face numerous resistances such as mucosal barriers, nonspecific drug accumulation and delivery due to uncontrolled drug release [66].…”

Section: Passive Targetingmentioning

confidence: 99%

Nanomedicines: A Focus on Nanomaterials as Drug Delivery System with Current Trends and Future Advancement

et al. 2022

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The rapid advancement of nanomedicine presents novel alternatives that have the potential to transform health care. Targeted drug delivery as well as the synthesis of nanocarriers is a growing discipline that has been intensively researched to reduce the complexity of present medicines in a variety of diseases and to develop new treatment and diagnostic techniques. There are several designed nanomaterials used as a delivery system such as liposomes, micelles, dendrimers, polymers, carbon-based materials, and many other substances, which deliver the drug moiety directly into its targeted body area reducing toxic effect of conventional drug delivery, thus reducing the amount of drug required for therapeutic efficacy and offering many more advantages. Currently, these are used in many applications, including cancer treatment, imaging contrast agents, and biomarker detection and so on. This review provides a comprehensive update in the field of targeted nano-based drug delivery systems, by conducting a thorough examination of the drug synthesis, types, targets, and application of nanomedicines in improving the therapeutic efficiency.

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Nano-delivery to the lung - by inhalation or other routes and why nano when micro is largely sufficient?

Cited by 59 publications

References 191 publications

Nanomedicines for targeted pulmonary delivery: receptor-mediated strategy and alternatives

Nanomedicines for targeted pulmonary delivery: receptor-mediated strategy and alternatives

Polymeric Nanoparticles for Inhaled Vaccines

Nanomedicines: A Focus on Nanomaterials as Drug Delivery System with Current Trends and Future Advancement

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