Nano-delivery of salvianolic acid B induces the quiescence of tumor-associated fibroblasts via interfering with TGF-β1/Smad signaling to facilitate chemo- and immunotherapy in desmoplastic tumor

Targeted nanomedicines remodeling immunosuppressive tumor microenvironment for enhanced cancer immunotherapy

“… 174 proposed multifunctional iron oxide nanoflowers decorated with gold nanoparticles (GIONF) as nanoheaters to deplete CAFs for reversing immunosuppressive TME, highlighting a spatiotemporally controlled physical strategy for cholangiocarcinoma treatment. Up to now, many CAFs inactivators have been leveraged to counteract the immunosuppression in TME to a certain degree, such as salvianolic acid B 175 , vismodegib 176 , telmisartan 177 , etc.…”

Fibroblasts as Turned Agents in Cancer Progression

“…Treatment of tumor-bearing mice with polyethylene glycol (PEG)ylated liposomes loaded with salvianolic acid-B (Dan Phenolic Acid A), a small molecule natural product used in traditional medicine as an antifibrotic, can interfere with CAFs by inhibiting the secretion of TGFβ1, reduce collagen deposition and increase the penetration of nanoparticles into tumors [ 538 ]. Treatment with Dan Phenolic Acid A results in high expression of Th1 cytokines and chemokines CXCL9 and CXCL10, recruitment of CD4 + , CD8 + T-cells, and M1 macrophages [ 538 ].…”

“…Treatment of tumor-bearing mice with polyethylene glycol (PEG)ylated liposomes loaded with salvianolic acid-B (Dan Phenolic Acid A), a small molecule natural product used in traditional medicine as an antifibrotic, can interfere with CAFs by inhibiting the secretion of TGFβ1, reduce collagen deposition and increase the penetration of nanoparticles into tumors [ 538 ]. Treatment with Dan Phenolic Acid A results in high expression of Th1 cytokines and chemokines CXCL9 and CXCL10, recruitment of CD4 + , CD8 + T-cells, and M1 macrophages [ 538 ]. Conversely, it induces low expression of Th2 cytokine and chemokine CXCL13, decreases myeloid-derived suppressor cells (MDSCs), Tregs, and M2 macrophages in the tumor area, inhibits tumor metastasis to the lungs, and significantly inhibits tumor growth when combined with docetaxel-loaded PEG-modified liposomes [ 538 ].…”

“…Treatment with Dan Phenolic Acid A results in high expression of Th1 cytokines and chemokines CXCL9 and CXCL10, recruitment of CD4 + , CD8 + T-cells, and M1 macrophages [ 538 ]. Conversely, it induces low expression of Th2 cytokine and chemokine CXCL13, decreases myeloid-derived suppressor cells (MDSCs), Tregs, and M2 macrophages in the tumor area, inhibits tumor metastasis to the lungs, and significantly inhibits tumor growth when combined with docetaxel-loaded PEG-modified liposomes [ 538 ].…”

Salvianolic acid B from Salvia miltiorrhiza bunge: A potential antitumor agent

“…Phospholipid complex-loaded nanoparticles (PLC-NPs) encapsulating Sal-B serve as potential carriers in HNSCC (HN13, HN30) cells and Leuk1 cells, inducing apoptosis and cell cycle arrest, increasing the biological activity of Sal-B in vivo ( Liu et al, 2007 ). Nano formulations encapsulate Sal-B within the backbone structure to enhance targeting and increase the drug bioavailability to improve the anticancer potential ( Chen et al, 2022b ; Liu et al, 2022 ). However, there are still few studies on the anti-head neck squamous cell carcinoma activity of Sal-B.…”