Nano-copper-bearing stainless steel promotes fracture healing by accelerating the callus evolution process

Wang, Lei; Li, Guoyuan; Ren, Ling; Kong, Xiangdong; Wang, Yugang; Han, Xiaozhe; Jiang, Wenbo; Dai, Kerong; Yang, Ke; Hao, Yongqiang

doi:10.2147/ijn.s146866

Cited by 26 publications

(21 citation statements)

References 45 publications

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“…The copper containing implants were then placed in an in vivo animal study, showing an increase in bone formation and bone-implant integration (Ren et al, 2015 ). Similar results were shown for nano-copper-bearing stainless steel, which were shown to increase osteogenic cell expression in vitro and to enhance bone formation in vivo (Wang L. et al, 2017 ).…”

Section: Osteogenic Actionssupporting

confidence: 73%

Biological Roles and Delivery Strategies for Ions to Promote Osteogenic Induction

Bosch-Rué

Díez-Tercero

Giordano-Kelhoffer

et al. 2021

Front. Cell Dev. Biol.

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Bone is the most studied tissue in the field of tissue regeneration. Even though it has intrinsic capability to regenerate upon injury, several pathologies and injuries could hamper the highly orchestrated bone formation and resorption process. Bone tissue engineering seeks to mimic the extracellular matrix of the tissue and the different biochemical pathways that lead to successful regeneration. For many years, the use of extrinsic factors (i.e., growth factors and drugs) to modulate these biological processes have been the preferred choice in the field. Even though it has been successful in some instances, this approach presents several drawbacks, such as safety-concerns, short release profile and half-time life of the compounds. On the other hand, the use of inorganic ions has attracted significant attention due to their therapeutic effects, stability and lower biological risks. Biomaterials play a key role in such strategies where they serve as a substrate for the incorporation and release of the ions. In this review, the methodologies used to incorporate ions in biomaterials is presented, highlighting the osteogenic properties of such ions and the roles of biomaterials in controlling their release.

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Section: Osteogenic Actionssupporting

confidence: 73%

Biological Roles and Delivery Strategies for Ions to Promote Osteogenic Induction

Bosch-Rué

Díez-Tercero

Giordano-Kelhoffer

et al. 2021

Front. Cell Dev. Biol.

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“…However, the development of surgical techniques and implant materials has greatly improved the prognosis of fractures [ 61 , 62 ]. Nonetheless, it was reported that 5%–10% of fractured bones ended in nonunion and/or incomplete healing, which could even lead to disability in some cases [ 63 ]. The principles for treating bone fractures mainly involve early treatment, anatomic reduction, and rigid fixation [ 64 , 65 ].…”

Section: Cu-containing Materials Promoting Bone Fracture Healingmentioning

confidence: 99%

Section: Cu-containing Materials Promoting Bone Fracture Healingmentioning

confidence: 99%

“…For example, Wang et al developed a novel nano-copper-bearing SS with nano-sized copper-precipitation (317L-Cu SS) to explore the effect of 317L-Cu SS on bone fracture healing in vivo . Their results demonstrated that 317L-Cu SS not only promoted osteogenic differentiation and the expression of osteogenesis-related genes, but also upregulated lysyl oxidase activity [ 63 ]. Subsequently, Huang et al employed a Cu-containing micro/nano-topographical bioceramic surface (Cu-Hier-Ti surface) as a material model to explore the role played by Cu 2+ release or the material surface in regulating macrophage-mediated osteogenic and bactericidal effects [ 6 ].…”

Section: Cu-containing Materials Promoting Bone Fracture Healingmentioning

confidence: 99%

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Biological applications of copper-containing materials

Wang

Yuan

et al. 2021

Bioactive Materials

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104

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Copper is an indispensable trace metal element in the human body, which is mainly absorbed in the stomach and small intestine and excreted into the bile. Copper is an important component and catalytic agent of many enzymes and proteins in the body, so it can influence human health through multiple mechanisms. Based on the biological functions and benefits of copper, an increasing number of researchers in the field of biomaterials have focused on developing novel copper-containing biomaterials, which exhibit unique properties in protecting the cardiovascular system, promoting bone fracture healing, and exerting antibacterial effects. Copper can also be used in promoting incisional wounds healing, killing cancer cells, Positron Emission Tomography (PET) imaging, radioimmunological tracing and radiotherapy of cancer. In the present review, the biological functions of copper in the human body are presented, along with an overview of recent progress in our understanding of the biological applications and development of copper-containing materials. Furthermore, this review also provides the prospective on the challenges of those novel biomaterials for future clinical applications.

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“…Previously, it has been reported that Cu 2+ elicits a significant upregulation in RUNX2 . However, RUNX2 is an early indicator of osteogenesis.…”

Section: Resultsmentioning

confidence: 96%

Functionalized TiCu/Ti‐Cu‐N‐Coated 3D‐Printed Porous Ti6Al4V Scaffold Promotes Bone Regeneration through BMSC Recruitment

Ren

Xie

et al. 2020

Adv Materials Inter

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Ti6Al4V scaffolds have high strength and corrosion resistance. 3D printing technology can optimize the pore structure of Ti6Al4V scaffolds, promoting bone tissue growth into the scaffolds to form firm osseointegrations. However, Ti6Al4V lacks biological activity. This defect can be overcome through surface modifications. Arc ion plating is employed to prepare titanium copper/titanium copper nitride (TiCu/Ti‐Cu‐N) multilayer coating, which is applied to 3D‐printed porous Ti6Al4V scaffolds by selective laser melting and bearing 300–400 µm pores. In addition to the excellent biological activity of copper, TiN shows superior corrosion resistance. The scaffold properties, osteogenesis, and osteointegration are evaluated in vitro and in vivo. Results show that human bone mesenchymal stem cells (hBMSCs) proliferate and adhere more effectively on coated scaffolds than on uncoated scaffolds. Further, the coating has a significant role in recruiting hBMSCs, and upregulation of the SDF‐1α/CXCR4 axis, p38 expression, and extracellular signal‐related kinase (Erk) and Akt signaling pathway. The in vitro results are further confirmed by an animal experiment in the New Zealand white rabbit femur tibia defect. Overall, the TiCu/Ti‐Cu‐N‐coated 3D‐printed Ti6Al4V scaffold shows excellent biocompatibility and bioactivity in promoting bone repair. The underlying mechanism may involve recruiting BMSCs and promoting their osteogenic differentiation.

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Nano-copper-bearing stainless steel promotes fracture healing by accelerating the callus evolution process

Cited by 26 publications

References 45 publications

Biological Roles and Delivery Strategies for Ions to Promote Osteogenic Induction

Biological Roles and Delivery Strategies for Ions to Promote Osteogenic Induction

Biological applications of copper-containing materials

Functionalized TiCu/Ti‐Cu‐N‐Coated 3D‐Printed Porous Ti6Al4V Scaffold Promotes Bone Regeneration through BMSC Recruitment

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