Nano-CoFe2O4 supported molybdenum as an efficient and magnetically recoverable catalyst for a one-pot, four-component synthesis of functionalized pyrroles

Li, Baole; Zhang, Mo; Hu, Hai‐Chuan; Du, Xiaosheng; Zhang, Zhan‐Hui

doi:10.1039/c3nj01368e

Cited by 91 publications

(26 citation statements)

References 73 publications

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“…As depicted in Scheme 14 for the synthesis of 1-(2-methyl-1,4-diphenyl-1H-pyrrol-3-yl)ethan-1-one, this methodology affords yields as high as the best previously reported systems, [69] but in a shorter reaction times and avoiding the use of the nitromethane as reaction media. Some drawbacks of the methodology were that alkyl aldehydes afforded inseparable complex reaction mixtures.…”

Section: Multicomponent Reactionsmentioning

confidence: 93%

Deep Eutectic Solvents: The Organic Reaction Medium of the Century

et al. 2016

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This microreview summarizes the use of deep eutectic solvents (DES) and related melts in Organic Synthesis. This type of solvents combine the great advantages of other proposed environmentally benign alternative solvents, such as low toxicity, high availability, low inflammability, high recyclability, low volatility and low price, avoiding many disadvantages of these neoteric media. The fact that many of the components of the mixture come directly from Nature assures their biodegradability and renewability. The classification and distribution of the reactions in different sections along this microreview, as well as the emphasis paid to their scope, easily allows a general reader to understand the actual state of art, and the great opportunities opened, not only for academic proposes but also for industry.

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Section: Multicomponent Reactionsmentioning

confidence: 93%

Deep Eutectic Solvents: The Organic Reaction Medium of the Century

et al. 2016

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“…Finally, the desired pyrrole is formed as a resul t of ring closure and aromatization thorough an intramolecular attack of amine followed by the elimination of an HNO and H 2 O from the molecule. 23,34 Scheme 2. Proposed mechanism To investigate the catalyst recyclability, the synthesis of 1a was selected as model reaction.…”

Section: Catalytic Application Of Nmnsmentioning

confidence: 99%

“…[20][21][22] Recently, magnetic nanoparticle CoFe 2 O 4 supported Mo ([CoFe 2 O 4 @SiO 2 -PrNH 2 -Mo(acac) 2 ]) has been used for a onepot synthesis of polysubstituted pyrroles via four-component reaction of aldehydes, amines, 1,3-dicarbonyl compounds, and nitromethane. 23 Although the catalyst is recoverable and the reaction times are generally short, the preparation of supported catalyst is time-consuming and needs to undergo several steps. Therefore, it seems logical to directly apply spinel ferrites to catalyze the reaction.…”

Section: Introductionmentioning

confidence: 99%

Nickel ferrite nanoparticles: an efficient and reusable nanocatalyst for a neat, one-pot and four-component synthesis of pyrroles

2015

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Rezvani• We applied magnetics NiFe 2 O 4 as a recoverable catalyst in the multicomponent reaction of substituted pyrroles • Magnetic NiFe 2 O 4 could be recovered from the reaction easily with an external magnet and be used nine times without significant activity loss. •The catalytic activity of magnetic NiFe 2 O 4 nanoparticles were less studied in organic reactions. • The reaction conditions is mild and the process of catalyst preparation is simple.• The yields are high.In this study nickel ferrite magnetic nanoparticles were applied as an efficient and reusable catalyst in the four-component synthesis of substituted pyrroles under neat conditions. The reaction was conducted using various amounts of catalyst at different temperatures and finally, application of 5 mol% of catalyst at 100°C was determined as the optimum reaction conditions. Results showed that nickel ferrite nanoparticles could catalyze the reaction at relatively short times (3-4 h) with high to excellent yields (70-96%). The catalyst could be recovered easily using an external magnetic field and be reused for nine times without any significant activity lost.

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“…Magnetic nanoparticles have been widely used in the immobilization of enzymes [35], bio-separation [36], biosensor [37], immunoassay [38], targeted drug delivery and hyperthermia [39], environmental analysis [40] and catalysis [41][42][43][44][45][46].…”

Section: Introductionmentioning

confidence: 99%