Nano CoCuFe2O4 catalyzed coupling reaction of acid chlorides with terminal alkynes: A powerful toolbox for palladium-free ynone synthesis

Graphitic Carbon Nitride Decorated with Cu2O Nanoparticles for the Visible Light Activated Synthesis of Ynones, Aminoindolizines, and Pyrrolo [1, 2-a] Quinoline

“…It has been indicated that copper formed a π-complex with the terminal alkyne i.e., copper nanoparticles activate the proton of the alkyne as nucleophile and by the deprotonation of the phenyl acetylene is taking place in the presence of base to form copper–acetylide complex. On the other hand, Moghaddam et al have shown that the copper nanocatalysts weaken the C–Cl bond present in benzoyl chloride that facilitates the coupling between benzoyl chloride and phenyl acetylene to afford high yield of ynones . The g-C 3 N 4 (graphitic carbon nitride) mainly contains tri-s-triazine framework connected by tertiary amines which make this material more effective as a photoactive catalyst having a band gap (2.72 eV).…”

“…However, high metal loading (5 mol %) was required to achieve good yield of ynone. 32 Presently, multicomponent reactions (MCR) conducted by efficient and reusable supported nanocatalysts provide an efficient and environmentally reliable route for the preparation of various complex heterocycles. 33,34 Indolozine and pyrrolo [1, 2-a] quinoline are important biologically active heterocycles that are present in many bioactive natural products (Figure 2).…”

“…On the other hand, Moghaddam et al have shown that the copper nanocatalysts weaken the C−Cl bond present in benzoyl chloride that facilitates the coupling between benzoyl chloride and phenyl acetylene to afford high yield of ynones. 32 The g-C 3 N 4 (graphitic carbon nitride) mainly contains tri-s-triazine framework connected by tertiary amines which make this material more effective as a photoactive catalyst having a band gap (2.72 eV). The photonic effect on the Cu 2 O NPs/g-C 3 N 4 toward the coupling of benzoyl chloride and phenyl acetylene catalyzed by irradiation of visible light is represented in Figure 8II.…”

“…Recently, Moghaddam et al have demonstrated magnetic separable CoCuFe 2 O 4 catalyst for the ynone synthesis. However, high metal loading (5 mol %) was required to achieve good yield of ynone …”

Acyl Sonogashira Cross-Coupling: State of the Art and Application to the Synthesis of Heterocyclic Compounds

“…Similar experimental conditions were used in the acylation of aryl acetylenes with benzoyl chloride promoted by a nanosized Cu2O/SiO2 egg-shell catalyst [66]. Finally, Moghaddam and coworkers [67] reported the application of cobalt-copper ferrite nanoparticles (CoCuFe2O4), obtained by the coprecipitation method, to the synthesis of alkynyl ketones by acyl Sonogashira reactions. The catalyst could be recovered using an external magnet, and then could be reused in up to nine reaction cycles, even though with a substantial reduction of its catalytic activity (from 90% to 70%) was observed.…”