Abstract:The aim of this study was to prepare and characterize piperinesuccinic acid nano-cocrystals in order to increase the solubility and dissolution rate of piperine. Nano-cocrystals were prepared using a wet-milling technique. Solid state characterization of the nano-cocrystals was performed by particle size analysis (PSA), powder X-ray diffraction (PXRD), differential scanning calorimetry (DSC), FT-IR spectroscopy, and scanning electron microscopy (SEM). Solubility and dissolution rate study were carried out in C… Show more
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