Nano-Co-Delivery of Berberine and Anticancer Drug Using PLGA Nanoparticles: Exploration of Better Anticancer Activity and In Vivo Kinetics

Khan, Iliyas; Joshi, Gaurav; Nakhate, Kartik T.; AJAZUDDIN, .; Kumar, Raj; Gupta, Umesh

doi:10.1007/s11095-019-2677-5

Cited by 55 publications

(32 citation statements)

References 36 publications

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“…Stressing the CYP2D6 and CYP3A4-mediated intestinal metabolism as one major factor for berberine's poor bioavailability, Khan et al [44] prepared a poly lactic-co-glycolic acid (PLGA) nanoparticles by encapsulating berberine with PLGA-doxorubicin conjugate (PDC). While the cytotoxicity in breast cancer cells (MDA-MB-231 and T47D lines) in vitro and in vivo in rats could be enhanced by up to 14-fold, the preparation has a far better transport in cultured Caco-2 cells and rat intestinal perfusion preparations due to improved permeability (5.5-fold) and reduced P-gl efflux (2-fold).…”

Section: Figurementioning

confidence: 99%

The Quest to Enhance the Efficacy of Berberine for Type-2 Diabetes and Associated Diseases: Physicochemical Modification Approaches

Habtemariam

2020

Biomedicines

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Berberine is a quaternary isoquinoline alkaloid that has been isolated from numerous plants which are still in use today as medicine and herbal supplements. The great deal of enthusiasm for intense research on berberine to date is based on its diverse pharmacological effects via action on multiple biological targets. Its poor bioavailability resulting from low intestinal absorption coupled with its efflux by the action of P-glycoprotein is, however, the major limitation. In this communication, the chemical approach of improving berberine’s bioavailability and pharmacological efficacy is scrutinised with specific reference to type-2 diabetes and associated diseases such as hyperlipidaemia and obesity. The application of modern delivery systems, research from combination studies to preparation of berberine structural hybrids with known biologically active compounds (antidiabetic, antihyperlipidaemic and antioxidant), as well as synthesis approaches of berberine derivative are presented. Improvement of bioavailability and efficacy through in vitro and ex vivo transport studies, as well as animal models of bioavailability/efficacy in lipid metabolism and diabetes targets are discussed.

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Section: Figurementioning

confidence: 99%

The Quest to Enhance the Efficacy of Berberine for Type-2 Diabetes and Associated Diseases: Physicochemical Modification Approaches

Habtemariam

2020

Biomedicines

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“…Importantly, the rapid development of new technologies and novel analysis methods, such as combinatorial syntheses, nanoparticle drug delivery systems and high‐throughput screenings, has brought a fresh perspective to the discovery and the design of new chemical constituents from natural sources. [ 34–36 ] The increasing attention to identifying natural products and the intense research and progress in doing so provide a fresh chemical bank for anticancer drug discovery for future clinical applications.…”

Section: Introductionmentioning

confidence: 99%

Tetrandrine: a review of its anticancer potentials, clinical settings, pharmacokinetics and drug delivery systems

Luan

Zeng

2020

Journal of Pharmacy and Pharmacology

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Objectives Tetrandrine, a natural bisbenzylisoquinoline alkaloid, possesses promising anticancer activities on diverse tumours. This review provides systematically organized information on cancers of tetrandrine in vivo and in vitro, discuss the related molecular mechanisms and put forward some new insights for the future investigations. Key findings Anticancer activities of tetrandrine have been reported comprehensively, including lung cancer, colon cancer, bladder cancer, prostate cancer, ovarian cancer, gastric cancer, breast cancer, pancreatic cancer, cervical cancer and liver cancer. The potential molecular mechanisms corresponding to the anticancer activities of tetrandrine might be related to induce cancer cell apoptosis, autophagy and cell cycle arrest, inhibit cell proliferation, migration and invasion, ameliorate metastasis and suppress tumour cell growth. Pharmaceutical applications of tetrandrine combined with nanoparticle delivery system including liposomes, microspheres and nanoparticles with better therapeutic efficiency have been designed and applied encapsulate tetrandrine to enhance its stability and efficacy in cancer treatment. Summary Tetrandrine was proven to have definite antitumour activities. However, the safety, bioavailability and pharmacokinetic parameter studies on tetrandrine are very limited in animal models, especially in clinical settings. Our present review on anticancer potentials of tetrandrine would be necessary and highly beneficial for providing guidelines and directions for further research of tetrandrine.

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“…Poly(lactic-co-glycolic acid) (PLGA)-based materials are frequently used in combination therapy of tumors [114]. Co-delivery of berberine and adriamycin via PLGA NPs using a conjugation/encapsulation strategy has been shown to exert a synergistic effect of the two drugs [115]. This method can significantly change the mitochondrial potential thus proving their mode of cell death via mitochondrial dependent pathway besides causing cell cycle arrest at G1 phase.…”

Section: Organic/inorganic Npsmentioning

confidence: 99%

Co-delivery of chemotherapeutic drugs and cell cycle regulatory agents using nanocarriers for cancer therapy

Sun

Jing

et al. 2021

Sci. China Mater.

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Combination chemotherapy is widely exploited to overcome multidrug resistance (MDR) and enhance the therapeutic effect of anti-tumor agents clinically. The traditional combination regimens applied in clinical practice still suffer from various obstacles, such as inevitable side effects. Fortunately, the application of nanotechnology and the proposal of co-delivery systems make the combination therapy more effective. The occurrence, development, and metastasis of tumors are closely related to the cell cycle. The sensitivity of tumor cells to chemotherapeutic drugs can be improved with the cooperation of cell cycle regulators. In this review, the influence of the cell cycle on tumorigenesis and development is introduced briefly. The current strategies of combining chemotherapeutic drugs and cell cycle regulators through codelivery systems are discussed in detail. We also sketch the possibility of treating tumors mildly via artificially controlling the cell cycle and outline the challenges and perspectives about the improvement of co-delivery systems for cancer therapy.

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Nano-Co-Delivery of Berberine and Anticancer Drug Using PLGA Nanoparticles: Exploration of Better Anticancer Activity and In Vivo Kinetics

Cited by 55 publications

References 36 publications

The Quest to Enhance the Efficacy of Berberine for Type-2 Diabetes and Associated Diseases: Physicochemical Modification Approaches

The Quest to Enhance the Efficacy of Berberine for Type-2 Diabetes and Associated Diseases: Physicochemical Modification Approaches

Tetrandrine: a review of its anticancer potentials, clinical settings, pharmacokinetics and drug delivery systems

Co-delivery of chemotherapeutic drugs and cell cycle regulatory agents using nanocarriers for cancer therapy

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