Nano-Carrier for Accentuated Transdermal Drug Delivery

Abstract

This research objective was to design a nano-carrier for Glibenclamide (GBD) by loading it in to nano-transfersomes to provide an accentuated transdermal drug delivery for Non-Insulin Dependent Diabetes Mellitus (NIDDM) The nanotransfersomes were prepared by sonication method and optimized using a statistically three-factor three-level Factorial Design (Box-Behnken design). A second order equation (polynomial) was originated and construct contour plots (2-D) for prediction the responses and characterized by various parameters (i.e. entrapment efficiency, vesicle shape & size, zeta potential, degree of deformability, permeation and skin irritation study). The skin permeation of optimized formulation (GNTs2) was found to be significantly higher (enhancement ratio is 10.44) than the drug in solution and also further confirmed by fluorescence microscopy using due i.e. Rhodamine B. Hence, drug loaded nano-transfersomes accentuates its transdermal flux and can be used as a nano-vehicle for NIDDM.