Nano-bio interaction: An overview on the biochemical binding of DNA to inorganic nanoparticles for the development of anticancer and antibacterial nano-platforms

Khan, Suliman; Cho, William C.; Jaragh-Alhadad, Laila A.; Tarharoudi, Rahil; Khan, Rizwan Hasan; Sari, Soyar; Falahati, Mojtaba; Hagen, Timo L.M. ten; Bai, Qian

doi:10.1016/j.ijbiomac.2022.11.110

Cited by 6 publications

(8 citation statements)

References 122 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Physically activated antibacterial strategies have the potential to address the issue of drug-resistant bacteria, but further research is required to deepen our understanding. Additionally, nano-mediated antibacterial strategies and the incorporation of natural antibacterial agents also impact their biocompatibility [ 110 ]. Moreover, the antibacterial mechanism of most substances of natural antibacterial agents needs further study.…”

Section: Discussionmentioning

confidence: 99%

Enhancing Bone Grafting Outcomes: A Comprehensive Review of Antibacterial Artificial Composite Bone Scaffolds

Liu

Cheng

et al. 2023

Med Sci Monit

View full text Add to dashboard Cite

Bone defects and dysfunctions are prevalent among patients, resulting from various causes such as trauma, tumors, congenital malformations, inflammation, and infection. The demand for bone defect repair materials is second only to blood transfusions. Artificial bone composites offer numerous advantages for bone damage repair, including their availability, absence of rejection or immune reactions, high malleability, exceptional mechanical strength, and outstanding biocompatibility. However, bacterial infections frequently occur during bone transplantation or on graft material structures, leading to severe complications such as osteomyelitis and osteoporosis. Moreover, existing osteogenic materials alone are inadequate to address the challenges posed by traumatic infections, presenting a significant hurdle for clinicians in reconstructing infectious bone defects. Consequently, it is crucial to functionalize artificial bone composites to facilitate effective bone repair and regeneration. Notably, antibacterial capabilities play a critical role in preventing and treating infectious bone defects, and current research is focusing on the interface between artificial bone composites and antibacterial treatments. This article provides an extensive review of the current state of artificial composite bone scaffolds with antibacterial properties for infection prevention in bone grafting.

show abstract

Section: Discussionmentioning

confidence: 99%

Enhancing Bone Grafting Outcomes: A Comprehensive Review of Antibacterial Artificial Composite Bone Scaffolds

Liu

Cheng

et al. 2023

Med Sci Monit

View full text Add to dashboard Cite

show abstract

“…Covid-19 triggers immune responses and activates inflammatory reactions soon after the viral entrance into the body[ 35 , 36 ]. Conventional thrombosis is developed by inflammation and complement activation, however, based on molecular level indications, researchers have reported unique involvement of NETosis in the case of COVID-19 pathophysiology[ 37 ]. The major components associated with processes are “activated platelets, tissue factor, and thrombin”, which contribute to thrombogenesis and are connected in a positive feedback loop[ 38 ].…”

Section: Thrombosis and Immune Regulations In Covid-19mentioning

confidence: 99%

“…Such virucidal and immunosuppressant based nanomedicines have been tested for treatment against COVID-19. In specific, virucidal nanoparticles appeared to be more effective in prevention of survival and replication of the virus[ 4 , 7 , 37 ]. Using nanomaterials with inherent virucidal properties is also an interesting approach such as using silver, and polylysine have been investigated.…”

Section: Immunosuppressant and Antiviral Based Nanomedicinesmentioning

confidence: 99%

“…Comparatively, glycyrrhizic acid nanoparticles showed limited efficacy, however, both polylysineand silver nanoparticles showed a positive correlation between their surface charge and antiviral activity. For optimal inhibition of the virus, silver nanoparticles showed size-dependent virucidal properties with 10 nm nanoparticles, while 100 nm nanoparticles were entirely ineffective[ 33 , 37 ]. Several groups that can utilize ACE2-expressing membranes to develop nanoconstructscan competitively bind and trap SARS-CoV-2.…”

Section: Immunosuppressant and Antiviral Based Nanomedicinesmentioning

confidence: 99%

“…Several groups that can utilize ACE2-expressing membranes to develop nanoconstructscan competitively bind and trap SARS-CoV-2. Furthermore, nanostructures generated by using these endogenously derived membranes show high biocompatibility, which can easily be core-loaded with therapeutics[ 33 , 37 , 47 ].…”

Section: Immunosuppressant and Antiviral Based Nanomedicinesmentioning

confidence: 99%

See 2 more Smart Citations

Advanced nanomedicines and immunotherapeutics to treat respiratory diseases especially COVID-19 induced thrombosis

Wu,

Zheng,

Zhang

et al. 2024

World J Clin Cases

View full text Add to dashboard Cite

Immunotherapy and associated immune regulation strategies gained huge attraction in order to be utilized for treatment and prevention of respiratory diseases. Engineering specifically nanomedicines can be used to regulate host immunity in lungs in the case of respiratory diseases including coronavirus disease 2019 (COVID-19) infection. COVID-19 causes pulmonary embolisms, thus new therapeutic options are required to target thrombosis, as conventional treatment options are either not effective due to the complexity of the immune-thrombosis pathophysiology. In this review, we discuss regulation of immune response in respiratory diseases especially COVID-19. We further discuss thrombosis and provide an overview of some antithrombotic nanoparticles, which can be used to develop nanomedicine against thrombo-inflammation induced by COVID-19 and other respiratory infectious diseases. We also elaborate the importance of immunomodulatory nanomedicines that can block pro-inflammatory signalling pathways, and thus can be recommended to treat respiratory infectious diseases.

show abstract

Advancements in Aptamer‐Driven DNA Nanostructures for Precision Drug Delivery

Safarkhani,

Ahmadi,

Ipakchi

et al. 2024

Advanced Science

View full text Add to dashboard Cite

DNA nanostructures exhibit versatile geometries and possess sophisticated capabilities not found in other nanomaterials. They serve as customizable nanoplatforms for orchestrating the spatial arrangement of molecular components, such as biomolecules, antibodies, or synthetic nanomaterials. This is achieved by incorporating oligonucleotides into the design of the nanostructure. In the realm of drug delivery to cancer cells, there is a growing interest in active targeting assays to enhance efficacy and selectivity. The active targeting approach involves a “key‐lock” mechanism where the carrier, through its ligand, recognizes specific receptors on tumor cells, facilitating the release of drugs. Various DNA nanostructures, including DNA origami, Tetrahedral, nanoflower, cruciform, nanostar, nanocentipede, and nanococklebur, can traverse the lipid layer of the cell membrane, allowing cargo delivery to the nucleus. Aptamers, easily formed in vitro, are recognized for their targeted delivery capabilities due to their high selectivity for specific targets and low immunogenicity. This review provides a comprehensive overview of recent advancements in the formation and modification of aptamer‐modified DNA nanostructures within drug delivery systems.

show abstract

Nano-bio interaction: An overview on the biochemical binding of DNA to inorganic nanoparticles for the development of anticancer and antibacterial nano-platforms

Cited by 6 publications

References 122 publications

Enhancing Bone Grafting Outcomes: A Comprehensive Review of Antibacterial Artificial Composite Bone Scaffolds

Enhancing Bone Grafting Outcomes: A Comprehensive Review of Antibacterial Artificial Composite Bone Scaffolds

Advanced nanomedicines and immunotherapeutics to treat respiratory diseases especially COVID-19 induced thrombosis

Advancements in Aptamer‐Driven DNA Nanostructures for Precision Drug Delivery

Contact Info

Product

Resources

About