Nano-Aptamer for Breast Cancer Imaging: Initial Considerations

Carmo, Fagner Santos do; Pinto, Suyenne Rocha; Orlando, Margarida Maria Camões; Albernaz, Marta de Souza; Junqueira, Mara de Souza; Bernardes, Emerson Soares; Cerecetto, Hugo; Moglioni, Albertina G.; Kozempel, Ján; Szwed, Marzena; Missailidis, Sotiris; Santos-Oliveira, Ralph

doi:10.17229/jdit.2015-0518-018

Cited by 5 publications

(2 citation statements)

References 19 publications

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“…Both [ 18 F]F-N-succinimidyl 4-18F-fluorobenzoate (FSB)tenascin-C and [ 64 Cu]Cu-NOTA-tenascin-C aptamers demonstrated significantly greater uptake in tenascin-C-positive tumours, U87MG and MDA-MB-231, compared to the tenascin-C-negative tumours, H460, suggesting that the aptamers did not lose their target specificity when radiolabelled with copper-64 for PET imaging in vivo [131] Thus, [ 68 Ga]Ga-aptamers could provide highly specific and sensitive cancer detection and therefore improve patient outcomes with advantages of speed and cost-efficiency [118]. While they are beyond the scope of this review article, other studies have investigated radiolabelling various aptamers to target cancer biomarkers for molecular imaging [128,[132][133][134][135][136][137][138]. Further, mAb radiolabelling techniques can be transferred to aptamers with ease to functionalise them as molecular imaging agents [22].…”

Section: Diagnostic Applicationsmentioning

confidence: 99%

Diagnostics and Therapeutics in Targeting HER2 Breast Cancer: A Novel Approach

Mandarano

Shigdar

2021

IJMS

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Breast cancer is one of the most commonly occurring cancers in women globally and is the primary cause of cancer mortality in females. BC is highly heterogeneous with various phenotypic expressions. The overexpression of HER2 is responsible for 15–30% of all invasive BC and is strongly associated with malignant behaviours, poor prognosis and decline in overall survival. Molecular imaging offers advantages over conventional imaging modalities, as it provides more sensitive and specific detection of tumours, as these techniques measure the biological and physiological processes at the cellular level to visualise the disease. Early detection and diagnosis of BC is crucial to improving clinical outcomes and prognosis. While HER2-specific antibodies and nanobodies may improve the sensitivity and specificity of molecular imaging, the radioisotope conjugation process may interfere with and may compromise their binding functionalities. Aptamers are single-stranded oligonucleotides capable of targeting biomarkers with remarkable binding specificity and affinity. Aptamers can be functionalised with radioisotopes without compromising target specificity. The attachment of different radioisotopes can determine the aptamer’s functionality in the treatment of HER2(+) BC. Several HER2 aptamers and investigations of them have been described and evaluated in this paper. We also provide recommendations for future studies with HER2 aptamers to target HER2(+) BC.

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Section: Diagnostic Applicationsmentioning

confidence: 99%

Diagnostics and Therapeutics in Targeting HER2 Breast Cancer: A Novel Approach

Mandarano

Shigdar

2021

IJMS

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“…The penultimate article, 'Nano-Aptamer for Breast Cancer Imaging: Initial Considerations', by Santos do Carmo et al [8]. The design of imaging and therapy agents based on nanoparticles towards the application of aptamers will enhance the development of novel drug delivery systems.…”

Section: Nano-aptamersmentioning

confidence: 99%

Editorial Review 2015 – Nuclear Medicine, Diagnostic Imaging and Therapy

Ciarmiello¹,

Mansi²

2016

J Diagn Imaging Ther

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Journal of Diagnostic Imaging in Therapy (JDIT) is published online by Open Medscience, based in Northern Ireland, UK. The aim of this journal is to address the requirements of researchersspecialising in nuclear medicine, diagnostic imaging and therapy by providing open access to peerreviewed articles. These high quality published articles are available in both HTML and PDF formats. All published articles are assigned an unique CrossRef DOI number and the HTML version is given a CrossMark accreditation.

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