Nano- and microparticles as adjuvants in vaccine design: Success and failure is related to host natural antibodies

Sinyakov, Michael S.; Dror, Moti; Lublin-Tennenbaum, Tammy; Salzberg, Samuel; Margel, Shlomo; Avtalion, Ramy R.

doi:10.1016/j.vaccine.2006.06.021

Cited by 42 publications

(13 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Epitope masking refers to the binding of antigen (the substance recognized as “foreign” by the immune system) by constitutive molecules, such as NAbs, which then reduce the amount of “free” antigen and the magnitude of the subsequent acquired response (Janeway et al, 2005). For example, in fish, there appears to be a general negative relationship between levels of NAbs and levels of acquired antibody produced in response to vaccinations (Sinyakov et al, 2002; Sinyakov et al, 2006; Sinyakov and Avtalion, 2009). The failure of water pythons ( Liasis fuscus ) to make an acquired antibody response to immunisations was attributed to such a masking function of NAbs (Madsen et al, 2007).…”

Section: Discussionmentioning

confidence: 99%

A trade-off between natural and acquired antibody production in a reptile: implications for long-term resistance to disease

et al. 2012

View full text Add to dashboard Cite

SummaryVertebrate immune systems are understood to be complex and dynamic, with trade-offs among different physiological components (e.g., innate and adaptive immunity) within individuals and among taxonomic lineages. Desert tortoises (Gopherus agassizii) immunised with ovalbumin (OVA) showed a clear trade-off between levels of natural antibodies (NAbs; innate immune function) and the production of acquired antibodies (adaptive immune function). Once initiated, acquired antibody responses included a long-term elevation in antibodies persisting for more than one year. The occurrence of either (a) high levels of NAbs or (b) long-term elevations of acquired antibodies in individual tortoises suggests that long-term humoral resistance to pathogens may be especially important in this species, as well as in other vertebrates with slow metabolic rates, concomitantly slow primary adaptive immune responses, and long life-spans.

show abstract

Section: Discussionmentioning

confidence: 99%

A trade-off between natural and acquired antibody production in a reptile: implications for long-term resistance to disease

et al. 2012

View full text Add to dashboard Cite

show abstract

“…The strategy of using Ag covalently linked to the MS surface to stimulate immune system cells and induce strong durable immune responses has been in use for quite some time [39]. An association of Ag and MS covalent coupling offers the following distinct advantages: less Ag is required, processing and presentation by APC is more efficient, stability during storage, and any excess material can easily be regained [40]. Doses of 1e5 mg of MS are used in various oral immunization protocols in humans [41].…”

Section: Discussionmentioning

confidence: 99%

A vaccine based on biodegradable microspheres induces protective immunity against scuticociliatosis without producing side effects in turbot

León-Rodríguez

Luzardo-Álvarez

Blanco-Méndez

et al. 2012

Fish & Shellfish Immunology

View full text Add to dashboard Cite

“…23 In addition, some nanomaterials have been investigated as vaccine adjuvants due to their unique physicochemical properties. 24 It was found that gold nanorods can be used as a promising vaccine adjuvant for anti-HIV treatment. 25 Carbon nanotubes have been reported to induce T-cell activation in vitro and in vivo; therefore carbon nanotubes have the potential to be used as vaccine adjuvants.…”

Section: Disclosure Of Potential Conflicts Of Interestmentioning

confidence: 99%

How can nanotechnology help membrane vesicle-based cancer immunotherapy development?

Tian

Zhu

Nie

2013

Human Vaccines & Immunotherapeutics

View full text Add to dashboard Cite

Exosomes are nanosized vesicles originating from endosomal compartments and secreted by most living cells. In the past decade, exosomes have emerged as potent tools for cancer immunotherapy due to their important roles in modulation of immune responses, and promising results have been achieved in exosome-based immunotherapy. The recent rapid progress of nanotechnology, especially on tailored design of nanocarriers for drug delivery based on both passive and active targeting strategies, sheds light on re-engineering native membrane vesicles for enhanced immune regulation and therapy. Applications of nanotechnology toolkits might provide new opportunity not only for value-added therapeutic or diagnostic strategies based on exosomes in cancer immunotherapy, but also new insights for biogenesis and biological relevance of membrane vesicles. This commentary focuses on the recent development and limitations of using exosomes in cancer immunotherapy and our perspectives on how nanomaterials with potential immune regulatory effects could be introduced into exosome-based immunotherapy.

show abstract

Nano- and microparticles as adjuvants in vaccine design: Success and failure is related to host natural antibodies

Cited by 42 publications

References 30 publications

A trade-off between natural and acquired antibody production in a reptile: implications for long-term resistance to disease

A trade-off between natural and acquired antibody production in a reptile: implications for long-term resistance to disease

A vaccine based on biodegradable microspheres induces protective immunity against scuticociliatosis without producing side effects in turbot

How can nanotechnology help membrane vesicle-based cancer immunotherapy development?

Contact Info

Product

Resources

About