Nano- and Microfibrous Materials Based on Collagen for Tissue Engineering: Synthesis, Structure, and Properties

Тенчурин, Т. Х.; Истранов, Л. П.; Истранова, Е. В.; Шепелев, А. Д.; Мамагулашвили, В. Г.; Малахов, С. Н.; Камышинский, Р. А.; Orekhov, Anton S.; Васильев, А. Л.; Sytina, E. V.; Krasheninnikov, Sergey V.; Чвалун, С. Н.

doi:10.1134/s1995078018050154

Cited by 5 publications

(4 citation statements)

References 31 publications

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“…The high dissolving power of HFIP and its ability to influence protein folding and structure have been exploited in materials science to promote hydrogen-bond driven construction of peptide- and nonpeptide-based supramolecular architectures with different properties and morphologies via self-assembly. − Improved solubility of vitamin B 2 in a highly polar solvent like HFIP allowed its use as a liquid organic dye laser . The hydrogen-bonding effect of HFIP on the electrospinning of biomaterials, proteins, and oligomers showed altered conductivity and rheology of the electrospinning solutions as well as improved morphology and properties of the resultant electrospun fibers. − For example, electrospinning of type I collagen in HFIP was studied to construct a biomimetic collagen nanofibrous extracellular matrix for tissue engineering . HFIP was used as a cosolvent with AcOH for the α-ketoacid–hydroxylamine (KAHA) ligation of exceptionally hydrophobic peptide segments to accomplish a chemical synthesis of the antibacterial cyclic AS-48 protein .…”

Section: Introductionmentioning

confidence: 99%

HFIP in Organic Synthesis

et al. 2022

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1,1,1,3,3,3-Hexafluoroisopropanol (HFIP) is a polar, strongly hydrogen bond-donating solvent that has found numerous uses in organic synthesis due to its ability to stabilize ionic species, transfer protons, and engage in a range of other intermolecular interactions. The use of this solvent has exponentially increased in the past decade and has become a solvent of choice in some areas, such as C–H functionalization chemistry. In this review, following a brief history of HFIP in organic synthesis and an overview of its physical properties, literature examples of organic reactions using HFIP as a solvent or an additive are presented, emphasizing the effect of solvent of each reaction.

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Section: Introductionmentioning

confidence: 99%

HFIP in Organic Synthesis

et al. 2022

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“…In the IR spectra of the composite materials (curves 2, 3), new absorption bands correspond to vibrations of the functional groups of chitosan and collagen appeared 27,32 . Thus, in the region of 3600 − 3200 cm −1 , a wide absorption band was detected with maxima at 3356 and 3290 cm −1 for chitosan and 3318 cm −1 for collagen, which related to stretching vibrations of NH bonds.…”

Section: Resultsmentioning

confidence: 92%

Study of highly porous poly‐l‐lactide‐based composites with chitosan and collagen

Antipova

Луканина

Krasheninnikov

et al. 2020

Polymers for Advanced Techs

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Increased interest in the field of tissue engineering promotes the development of biomaterial design. Aspiration to reconstruct native extracellular matrix architecture (ECM) expands the number of applying approaches in polymer scaffold development. In the present work, we proposed a combination of electrospinning and lyophilization techniques to produce materials with ECM‐like morphology based on poly‐l‐lactide fiber matrix with natural bio‐adequate fillers (collagen and chitosan). Morphology, mechanical properties, and hydrophilicity of the developed biomaterials were studied. The introduction of the collagen filler enhanced the strength and Young's modulus of the composites by 190% and 80%. The same characteristics of the chitosan‐containing material were increased by 430% and 340%, respectively. It exceeded the collagen ones, which was caused by the better chitosan penetration into the fiber matrix and, as a result, the percolation network formation. The possibility of material wettability improving was shown.

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“…Due to the low stability of the fibrous structure in aqueous media, the resulting fibrous materials were cross‐linked with genipin (Figure 1D–F) according to the technology developed and described in detail earlier 22 . The selected conditions of cross‐linking allow to preserve the fibrous structure completely (Figure 1D–F).…”

Section: Resultsmentioning

confidence: 99%

Effect of collagen denaturation degree on mechanical properties and biological activity of nanofibrous scaffolds

Tenchurin,

Sytina,

Solovieva

et al. 2023

J Biomedical Materials Res

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Further progress in regenerative medicine and bioengineering highly depends on the development of 3D polymeric scaffolds with active biological properties. The most attention is paid to natural extracellular matrix components, primarily collagen. Herein, nonwoven nanofiber materials with various degrees of collagen denaturation and fiber diameters 250–500 nm were produced by electrospinning, stabilized by genipin, and characterized in detail. Collagen denaturation has been confirmed using DSC and FTIR analysis. The comparative study of collagen and gelatin nonwoven materials (NWM) revealed only minor differences in their biocompatibility with skin fibroblasts and keratinocytes in vitro. In long‐term subcutaneous implantation study, the inflammation was less evident on collagen than on gelatin NWM. Remarkably, the pronounced calcification was revealed in the collagen NWM only. The results obtained can be useful in terms of improving the electrospinning technology of collagen from aqueous solutions, as well as emphasize the importance of long‐term study to ensure proper implementation of the material, taking into account the ability of collagen to provoke calcification.

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Nano- and Microfibrous Materials Based on Collagen for Tissue Engineering: Synthesis, Structure, and Properties

Cited by 5 publications

References 31 publications

HFIP in Organic Synthesis

HFIP in Organic Synthesis

Study of highly porous poly‐l‐lactide‐based composites with chitosan and collagen

Effect of collagen denaturation degree on mechanical properties and biological activity of nanofibrous scaffolds

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