Nandrolone decanoate safely combats catabolism in burned patients: A new potential indication after recall

Ali, Yasser; Ali, Tasnim

doi:10.1016/j.burns.2021.04.011

Cited by 4 publications

(2 citation statements)

References 27 publications

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“…Instead, some burn centers use another anabolic steroid, nandrolone decanoate (ND). A prospective randomized control study from 2022, which included 40 patients burned on 20-40% of their TBSA, confirmed the effectiveness of ND in combating catabolic symptoms in burn patients, manifested in the form of improved nitrogen balance and the preservation of lean body mass [379].…”

Section: Nutrition/hypermetabolismmentioning

confidence: 77%

An Overview of Recent Developments in the Management of Burn Injuries

Radzikowska-Büchner,

Łopuszyńska,

Flieger

et al. 2023

IJMS

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According to the World Health Organization (WHO), around 11 million people suffer from burns every year, and 180,000 die from them. A burn is a condition in which heat, chemical substances, an electrical current or other factors cause tissue damage. Burns mainly affect the skin, but can also affect deeper tissues such as bones or muscles. When burned, the skin loses its main functions, such as protection from the external environment, pathogens, evaporation and heat loss. Depending on the stage of the burn, the patient’s condition and the cause of the burn, we need to choose the most appropriate treatment. Personalization and multidisciplinary collaboration are key to the successful management of burn patients. In this comprehensive review, we have collected and discussed the available treatment options, focusing on recent advances in topical treatments, wound cleansing, dressings, skin grafting, nutrition, pain and scar tissue management.

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Section: Nutrition/hypermetabolismmentioning

confidence: 77%

An Overview of Recent Developments in the Management of Burn Injuries

Radzikowska-Büchner,

Łopuszyńska,

Flieger

et al. 2023

IJMS

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“…Many pharmacological and non-pharmacological strategies have been tried and investigated in the treatment of burns with varying degrees of success (Ali and Ali 2022 ).…”

Section: Introductionmentioning

confidence: 99%

Mesenchymal stem cell transplantation in burn wound healing: uncovering the mechanisms of local regeneration and tissue repair

El-Sayed,

Atwa,

Sofy

et al. 2023

Histochem Cell Biol

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Burn injuries pose a significant healthcare burden worldwide, often leading to long-term disabilities and reduced quality of life. To explore the impacts of the transplantation of mesenchymal stem cells (MSCs) on the healing of burns and the levels of serum cytokines, 60 fully grown Sprague–Dawley rats were randomly divided into three groups (n = 20 each): group I (control), group II (burn induction), and group III (burn induction + bone marrow (BM)-MSC transplantation). Groups II and III were further divided into four subgroups (n = 5 each) based on euthanasia duration (7, 14, 21, and 28 days post transplant). The experiment concluded with an anesthesia overdose for rat death. After 7, 14, 21, and 28 days, the rats were assessed by clinical, laboratory, and histopathology investigations. The results revealed significant improvements in burn healing potentiality in the group treated with MSC. Furthermore, cytokine levels were measured, with significant increases in interleukin (IL)-6 and interferon alpha (IFN) observed, while IL-10 and transforming growth factor beta (TGF-β) decreased at 7 days and increased until 28 days post burn. Also, the group that underwent the experiment exhibited increased levels of pro-inflammatory cytokines and the anti-inflammatory cytokine IL-10 when compared to the control group. Histological assessments showed better re-epithelialization, neovascularization, and collagen deposition in the experimental group, suggesting that MSC transplantation in burn wounds may promote burn healing by modulating the immune response and promoting tissue regeneration.

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An Appraisal of Pharmacotherapy-Pertinent Literature Published in 2021 and 2022 for Clinicians Caring for Patients With Thermal or Inhalation Injury

Hill,

Reger,

Todor

et al. 2024

Journal of Burn Care &Amp; Research

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Studies focusing on pharmacotherapy interventions to aid patients after thermal injury are a minor focus in burn injury-centered studies and published across a wide array of journals, which challenges those with limited resources to keep their knowledge current. This review is a renewal of previous years’ work to facilitate extraction and review of the most recent pharmacotherapy-centric studies in patients with thermal and inhalation injury. Twenty-three geographically dispersed, board-certified pharmacists participated in the review. A MeSH-based, filtered search returned 2,336 manuscripts over the previous 2-year period. After manual review, 98 (4%) manuscripts were determined to have a potential impact on current pharmacotherapy practice. The top 10 scored manuscripts are discussed. Only 17% of those reviewed were assessed to likely have little effect on current practice. The overall impact of the current cohort was higher than previous editions of this review, which is encouraging. There remains a need for investment in well-designed, high impact, pharmacotherapy-pertinent research for patients sustaining thermal or inhalation injuries.

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Nandrolone decanoate safely combats catabolism in burned patients: A new potential indication after recall

Cited by 4 publications

References 27 publications

An Overview of Recent Developments in the Management of Burn Injuries

An Overview of Recent Developments in the Management of Burn Injuries

Mesenchymal stem cell transplantation in burn wound healing: uncovering the mechanisms of local regeneration and tissue repair

An Appraisal of Pharmacotherapy-Pertinent Literature Published in 2021 and 2022 for Clinicians Caring for Patients With Thermal or Inhalation Injury

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