NANC neural control of airway smooth muscle tone

Lindén, Anders

doi:10.1016/0306-3623(95)02142-6

Cited by 13 publications

(5 citation statements)

References 105 publications

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“…Potential explanations for the response to either challenge include release of inflammatory mediators by mast cells, denervation with disruption of the balance between excitatory and inhibitory sympathetic and parasympathetic pathways, and loss of inhibition of the putative inhibitory and excitatory, immunomodulatory, nonadrenergic/noncholinergic system. [15][16][17][18] Interestingly, we found that size matching affected the response to HS and a small donor lung in a larger recipient resulted in increased responsiveness. This was unexpected because one would expect an already "stretched" airway to be less responsive to a bronchoconstrictor challenge.…”

Section: Discussionmentioning

confidence: 91%

Bronchial hyperresponsiveness and the bronchiolitis obliterans syndrome after lung transplantation

Reid

Walters

Johns

et al. 2005

The Journal of Heart and Lung Transplantation

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Section: Discussionmentioning

confidence: 91%

Bronchial hyperresponsiveness and the bronchiolitis obliterans syndrome after lung transplantation

Reid

Walters

Johns

et al. 2005

The Journal of Heart and Lung Transplantation

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“…Human airway has non-adrenergic, non-cholinergic (NANC) innervation which mediates (excitatory) bronchoconstriction via tachykinins, substance P and neurokinin A. The inhibitory component of NANC mediates bronchodilation via vasoactive intestinal peptide and NO (Belvisi et al, 1995; Joos et al, 2000; Lammers et al, 1992; Linden, 1996; Mackay et al, 1998; van der Velden & Hulsmann, 1999; Ward et al, 1995). Neuronal NOS in NANC nerve fibers generates NO from arginine which then induces ASM relaxation.…”

Section: Contribution Of Sex Steroids To Airway Structure and Funcmentioning

confidence: 99%

Sex steroid signaling: Implications for lung diseases

Sathish

Martin

Prakash

2015

Pharmacology & Therapeutics

136

134

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There is increasing recognition that the sex hormones (estrogen, progesterone, and testosterone) have biological and pathophysiological actions in peripheral, non-reproductive organs, including the lung. Clinically, sex differences in the incidence, morbidity and mortality of lung diseases such as asthma, chronic obstructive pulmonary disease (COPD), pulmonary fibrosis, lung cancer and pulmonary hypertension have been noted, although intrinsic sex differences vs. the roles of sex steroids are still not well-understood. Accordingly, it becomes important to ask the following questions: 1) Which sex steroids are involved? 2) How do they affect different components of the lung under normal circumstances? 3) How does sex steroid signaling change in or contribute to lung disease, and in this regard, are sex steroids detrimental or beneficial? As our understanding of sex steroid signaling in the lung improves, it is important to consider whether such information can be used to develop new therapeutic strategies to target lung diseases, perhaps in both sexes or in a sex-specific manner. In this review, we focus on the basics of sex steroid signaling, and the current state of knowledge regarding how they influence structure and function of specific lung components across the life span and in the context of some important lung diseases. We then summarize the potential for sex steroids as useful biomarkers and therapeutic targets in these lung diseases as a basis for future translational research in the area of gender and individualized medicine.

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“…Design for reflex protection of the airway via bidirectional central nervous system (CNS)-airway pathways, repeated exposures to environmental pollutants, inflammatory stimuli, and other noxious agents may modulate afferent airway sensory pathways (150,315,316), leading to increased excitability of airway-related vagal preganglionic neurons and airway hyperresponsiveness. The extensive and exquisite neural control of airways has been previously reviewed (150,177,317,318). CNS control of the airway involves integrated netReview L920 NOVEL ROLES OF AIRWAY SMOOTH MUSCLE works along the central neural axis, particularly the vagal preganglionic neurons within the medulla, which form the final common pathway from the brain to the airways.…”

Section: Neural Controlmentioning

confidence: 99%

Airway smooth muscle in airway reactivity and remodeling: what have we learned?

Prakash

2013

American Journal of Physiology-Lung Cellular and Molecular Phys

177

154

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Prakash YS. Airway smooth muscle in airway reactivity and remodeling: what have we learned? Am J Physiol Lung Cell Mol Physiol 305: L912-L933, 2013. First published October 18, 2013 doi:10.1152/ajplung.00259.2013.-It is now established that airway smooth muscle (ASM) has roles in determining airway structure and function, well beyond that as the major contractile element. Indeed, changes in ASM function are central to the manifestation of allergic, inflammatory, and fibrotic airway diseases in both children and adults, as well as to airway responses to local and environmental exposures. Emerging evidence points to novel signaling mechanisms within ASM cells of different species that serve to control diverse features, including 1) [Ca 2ϩ ]i contractility and relaxation, 2) cell proliferation and apoptosis, 3) production and modulation of extracellular components, and 4) release of pro-vs. anti-inflammatory mediators and factors that regulate immunity as well as the function of other airway cell types, such as epithelium, fibroblasts, and nerves. These diverse effects of ASM "activity" result in modulation of bronchoconstriction vs. bronchodilation relevant to airway hyperresponsiveness, airway thickening, and fibrosis that influence compliance. This perspective highlights recent discoveries that reveal the central role of ASM in this regard and helps set the stage for future research toward understanding the pathways regulating ASM and, in turn, the influence of ASM on airway structure and function. Such exploration is key to development of novel therapeutic strategies that influence the pathophysiology of diseases such as asthma, chronic obstructive pulmonary disease, and pulmonary fibrosis.

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NANC neural control of airway smooth muscle tone

Cited by 13 publications

References 105 publications

Bronchial hyperresponsiveness and the bronchiolitis obliterans syndrome after lung transplantation

Bronchial hyperresponsiveness and the bronchiolitis obliterans syndrome after lung transplantation

Sex steroid signaling: Implications for lung diseases

Airway smooth muscle in airway reactivity and remodeling: what have we learned?

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