NALT (nasal cavity-associated lymphoid tissue) in the rabbit

Casteleyn, Christophe; Broos, Anouk; Simoens, Paul; Broeck, Wim Van Den

doi:10.1016/j.vetimm.2009.08.011

Cited by 36 publications

(32 citation statements)

References 41 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The lamina propria mucosae of the avian pharyngeal wall contains diffusely disseminated or more compactly aggregated lymphoid cells (often named lamina propria lymphocytes; Casteleyn et al, 2009), and sometimes a few small lymphoid follicles (B1 mm) that may comprise a germinal centre (Schummer, 1973;Tudor & Woodward, 1975;Arai et al, 1988). Most of the lymphoid tissue is present around the choanal and infundibular clefts just rostral to the pharyngeal papillae (Grau-Karlsbad, 1943;Schummer, 1973;King & McLelland, 1975;Kö nig et al, 2001).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Locations of gut-associated lymphoid tissue in the 3-month-old chicken: a review

et al. 2010

Self Cite

View full text Add to dashboard Cite

Section: Introductionmentioning

confidence: 99%

“…A lymphoid tissue consisting of aggregated lymphoid cells and lymphoid follicles is present at the nasal side of the palate. This lymphoid tissue resembles the tonsil of the ovine soft palate and could be designated nasal cavity-associated lymphoid tissue (Casteleyn et al, 2007(Casteleyn et al, , 2009). …”

Section: Introductionmentioning

confidence: 99%

Locations of gut-associated lymphoid tissue in the 3-month-old chicken: a review

et al. 2010

Self Cite

View full text Add to dashboard Cite

“…The nasopharynx-associated lymphoid tissue (NALT) is composed of a bell-shaped structure located in the nasal passages above the hard palate of rodents and other mammals (2,7,10). In mice, NALT organogenesis begins soon after birth and is dependent on several factors, including various chemokines and cytokines, as well as environmental cues (15,17,24,35).…”

mentioning

confidence: 99%

Nasal Immunity to Staphylococcal Toxic Shock Is Controlled by the Nasopharynx-Associated Lymphoid Tissue

Fernandez

Cisney

Hall

et al. 2011

Clin Vaccine Immunol

View full text Add to dashboard Cite

The nasopharynx-associated lymphoid tissue (NALT) of humans and other mammals is associated with immunity against airborne infections, though it is generally considered to be a secondary component of the mucosa-associated lymphoid system. We found that protective immunity to a virulence factor of nasal mucosacolonizing Staphylococcus aureus, staphylococcal enterotoxin B (SEB), requires a functional NALT. We examined the role of NALT using intranasal (

show abstract

“…The IgA-committed B cells migrate from the NALT to diffuse mucosal tissue sites, including nasal passages (37,38). The NALTs are ideally situated in the nasal passages above the hard palate of rodents and other mammals to access aerosolized antigens from pathogens, vaccines, or other sources that enter the respiratory tract (14,40,41). NALT organogenesis begins soon after birth and is dependent on several factors, including various chemokines, cytokines, and environmental cues (42)(43)(44)(45).…”

Section: Discussionmentioning

confidence: 99%

Enhancement of Serum and Mucosal Immune Responses to a Haemophilus influenzae Type B Vaccine by Intranasal Delivery

Fernandez

Cisney

Ulrich

2013

Clin Vaccine Immunol

View full text Add to dashboard Cite

Intranasal (i.n.) vaccination is potentially the most direct method for conveying upper respiratory and mucosal immunity to respiratory pathogens. However, for unclear reasons, vaccines introduced into the nasal sinuses often have lower efficacy than vaccines administered by the more frequently used parenteral routes. We examined i.n. vaccination in a mouse immune-response model with a commonly used Haemophilus influenzae type B vaccine (Hibv) composed of the polyribosylribitol phosphate (PRP) capsule antigen conjugated to tetanus toxoid. Intranasal vaccination with Hibv using a Toll-like receptor 4 (TLR4) agonist as an adjuvant significantly increased the levels of IgA specific for the PRP capsule antigen in blood serum, saliva, and mucosal secretion specimens. In contrast, control mice vaccinated transdermally (t.d.) with Hibv did not produce significant levels of PRP-specific IgA in the blood serum and saliva, and anti-PRP IgG was increased only in serum. The i.n. and t.d. vaccinations resulted in equivalent bactericidal antibody responses in blood serum, suggesting that vaccine-derived IgG is protective against infection. Elevated levels of IgG specific for the tetanus toxoid carrier protein were measured in nasal sinuses and vaginal secretions in mice vaccinated by either the t.d. or i.n. route. Tissue culture studies confirmed that the nasopharynx-associated lymphoid tissue (NALT) was at least one of the sources of PRP-specific IgA and carrier-specific IgG within the nasal sinuses. We conclude that i.n. vaccination aided by a TLR4 agonist results in robust immune responses to both the carrier protein and bacterial polysaccharide components of the Hibv. Haemophilus influenzae type b (Hib) vaccines (Hibv) are widely used in the pediatric population and require several intramuscular vaccination rounds of to achieve optimal efficacy. Children are significant reservoirs of Hib, with carriage rates ranging from 4.2% to 9% in the school-aged population (1, 2). Vaccination with the Hib vaccine significantly reduces Hib carriage in the pediatric population (3). Despite the widespread use and existence of the Hib vaccine, the annual burden of Hib infection continues to reach millions of cases worldwide and fatalities of several hundred thousand in children Յ5 years of age (4). Hib infection is spread by aerosolized droplets, with the nasal passages being the primary portal of entry, and can lead to meningitis, epiglottitis, pneumonia, cellulitis, and arthritis. The primary component of the Hib vaccine is polyribosylribitol phosphate (PRP), a ubiquitous polysaccharide of the bacterial outer wall that is delivered either with or without an aluminum-based adjuvant (5). Like all polysaccharides, the PRP moiety is poorly immunogenic (6), and conjugation to a protein carrier, such as tetanus toxoid (TT), is required to significantly increase vaccine immunogenicity (7). The internalization of PRP-protein conjugates by antigen-presenting cells (APC) followed by major histocompatibility complex (MHC) presentation (6, 8) is r...

show abstract

NALT (nasal cavity-associated lymphoid tissue) in the rabbit

Cited by 36 publications

References 41 publications

Locations of gut-associated lymphoid tissue in the 3-month-old chicken: a review

Locations of gut-associated lymphoid tissue in the 3-month-old chicken: a review

Nasal Immunity to Staphylococcal Toxic Shock Is Controlled by the Nasopharynx-Associated Lymphoid Tissue

Enhancement of Serum and Mucosal Immune Responses to a Haemophilus influenzae Type B Vaccine by Intranasal Delivery

Contact Info

Product

Resources

About