Naloxone reversal of stress-induced reproductive effects in the male rhesus monkey

Gilbeau, Pamela M.; Smith, Carol Grace

doi:10.1016/0143-4179(85)90021-6

Cited by 27 publications

(10 citation statements)

References 3 publications

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“…However, it appears likely that some hormonal and neural factors are involved in hampering both sperm production and the transport of spermatozoa through the male genital ducts during acute stress that is associated with semen collection. In that context, stress has been shown to decrease LH and T concentrations in the male rhesus monkey via a pathway involving endogenous opioid peptides (19,20). The cited investigators suggested that the reduction in these hormones was responsible for subsequent disruption of the spermatozoa in the monkeys.…”

Section: Discussionmentioning

confidence: 93%

Comparison of semen parameters in samples collected by masturbation at a clinic and at home

Elzanaty

Malm

2008

Fertility and Sterility

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Section: Discussionmentioning

confidence: 93%

Comparison of semen parameters in samples collected by masturbation at a clinic and at home

Elzanaty

Malm

2008

Fertility and Sterility

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“…Nevertheless, the reduction in LH pulse amplitude observed may indicate that the effect of stress was mediated by activation of inhibitory pathways impinging on the LHRH nerve terminals in the median eminence, thereby reducing the amount of LHRH released to evoke each LH pulse. There is con¬ siderable evidence that endogenous opioid peptides play such a modulatory role in stress-induced effects on reproductive function (Briski, Quigley & Meites, 1984;Gilbeau & Smith, 1985;Petraglia, Vale & Rivier, 1986). Preliminary results from our laboratory support this hypothesis; the inhibition of LH secretion following receipt of aggression and physical restraint can be reversed by the opioid antagonist naloxone.…”

Section: Discussionmentioning

confidence: 98%

Effects of acute stress on the patterns of LH secretion in the common marmoset (Callithrix jacchus)

O’Byrne

Lunn²,

Dixson³

1988

Journal of Endocrinology

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Stressful stimuli associated with aggressive encounters and low social rank may affect female fertility in a variety of mammalian species. In these experiments we examined the effects of aggressive encounters and physical restraint in a primate chair on the patterns of LH secretion in ovariectomized, oestrogen-primed female marmosets. Receipt of aggression from a female conspecific, followed by physical restraint for collection of blood samples (at 10-min intervals for 4 h), resulted in marked declines in LH concentrations during oestradiol-induced LH surges in five animals (from 112 +/- 24 micrograms/l to 45 +/- 12 micrograms/l; group means +/- S.E.M.; P less than 0.05). This was due to reductions in LH pulse amplitude rather than to changes in pulse frequency. Decreases in plasma concentrations of LH were reversed by treating females with exogenous LH-releasing hormone (LHRH). Cortisol treatment had no effect on LH levels during oestrogen-induced LH surges. Effects of aggressive encounters and physical restraint on plasma LH were not therefore due to reduced pituitary responsiveness to LHRH or to increased plasma concentrations of cortisol. In separate experiments it was found that physical restraint alone had no effect on plasma LH in habituated subjects, and that decreases in plasma LH after receipt of aggression only occurred if animals were subsequently placed in the restraint chair. A summation of stressful effects is therefore required to produce the fall in circulating LH. A summation of social and other environmental stressors may also underlie the reduced fertility seen in free-living animals.

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“…Salivary testosterone levels exhibit sharp declines along with concurrent rises in glucocorticoid levels in response to acute stresses such as skydiving (Chatterton et al, 1997), suggesting that cortisol increases may underlie HPT suppression in stressed males (Bambino and Hsueh, 1981;Doerr and Pirke, 1976). In nonhuman primates, naloxone treatment reverses stress-induced LH suppression in male rhesus monkeys, suggesting that endogenous opioids may also play a role in stressinduced reproductive suppression in primates at the level of the hypothalamus (Gilbeau and Smith, 1985).…”

Section: Libidomentioning

confidence: 99%

Reproductive ecology and life history of the human male

Bribiescas

2001

Am. J. Phys. Anthropol.

210

117

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Until recently, the reproductive ecology of human males has not been extensively investigated, primarily as a result of the need for a theoretical framework based on the reproductive constraints and energetics of mammalian males. More specifically, male reproductive ecology has necessitated an integrative interpretation of clinical and anthropological data based on the premise that the evolution of human male life histories has involved selection for physiological mechanisms aimed at optimizing trade-offs between survivorship and reproductive effort. This paper attempts to address this gap in our understanding by presenting the current state of male reproductive ecology, including physiologic data from clinical and anthropological investigations as well as recent theoretical developments. Recent investigations outlining population variation in reproductive endocrine function are discussed within the context of potential sources of variation, including energetic expediture, caloric intake, and developmental canalization during adolescence. Additional summaries of male senescence and behavior are presented to provide a complete overview of male life history. Implications of recent anthropological data on contemporary health issues such as prostate cancer and the development of a male contraceptive are also discussed. Finally, several theories are presented that may contribute to our understanding of the evolution of male life histories and reproductive ecology, including theoretical suggestions involving the role of competition, mate choosiness, and potential constraints on male insemination ability, as well as a theory suggesting that male reproductive ecology may be best understood by analyzing energetic allocation decisions between differing somatic tissues that may be indicative of the competing needs for optimizing survivorship and reproductive effort. Directions for future research are finally considered.

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Naloxone reversal of stress-induced reproductive effects in the male rhesus monkey

Cited by 27 publications

References 3 publications

Comparison of semen parameters in samples collected by masturbation at a clinic and at home

Comparison of semen parameters in samples collected by masturbation at a clinic and at home

Effects of acute stress on the patterns of LH secretion in the common marmoset (Callithrix jacchus)

Reproductive ecology and life history of the human male

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