Naloxone-precipitated withdrawal jumping in 11 inbred mouse strains: evidence for common genetic mechanisms in acute and chronic morphine physical dependence

Kest, Benjamin; Palmese, Christina A.; Hopkins, Eileen; Adler, Michael; Juni, Aaron; Mogil, Jeffrey S.

doi:10.1016/s0306-4522(02)00458-x

Cited by 123 publications

(135 citation statements)

References 27 publications

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“…Among the 5 inbred strains and one outbred stock examined, only the BALB/cJ strain exhibited vertical leaping behavior in response to d-amphetamine (McKerchar et al, 2006). McKerchar et al (2006) describe some similarities in strain sensitivities to vertical leaping induced by d-amphetamine, dizocilpine (Deutsch et al, 1997) and naloxone-precipitated morphine withdrawal (Kest et al, 2002), although they point out the difficulty in making meaningful comparisons due to differences in dosing regimens and methods for quantification. In the course of measuring leaping behavior across the 5 treatment days, behavioral sensitization was seen in bouts of low mobility (a measure of spatial confinement due to focused stereotypy).…”

Section: Inbred Strainsmentioning

confidence: 99%

Behavioral genetic contributions to the study of addiction-related amphetamine effects

Phillips

Kamens

Wheeler

2008

Neuroscience & Biobehavioral Reviews

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Amphetamines, including methamphetamine, pose a significant cost to society due to significant numbers of amphetamine-abusing individuals who suffer major health-related consequences. In addition, methamphetamine use is associated with heightened rates of violent and property-related crimes. The current paper reviews the existing literature addressing genetic differences in mice that impact behavioral responses thought to be relevant to the abuse of amphetamine and amphetaminelike drugs. Summarized are studies that used inbred strains, selected lines, single gene knockouts and transgenics, and quantitative trait locus (QTL) mapping populations. Acute sensitivity, neuroadaptive responses, rewarding and conditioned effects are among those reviewed. Some gene mapping work has been accomplished, and although no amphetamine-related complex trait genes have been definitively identified, translational work leading from results in the mouse to studies performed in humans is beginning to emerge. The majority of genetic investigations has utilized single-gene knockout mice and has concentrated on dopamine-and glutamate-related genes. Genes that code for cell support and signaling molecules are also well-represented. There is a large behavioral genetic literature on responsiveness to amphetamines, but a considerably smaller literature focused on genes that influence the development and acceleration of amphetamine use, withdrawal, relapse, and behavioral toxicity. Also missing are genetic investigations into the effects of amphetamines on social behaviors. This information might help to identify at-risk individuals and in the future to develop treatments that take advantage of individualized genetic information.

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Section: Inbred Strainsmentioning

confidence: 99%

Behavioral genetic contributions to the study of addiction-related amphetamine effects

Phillips

Kamens

Wheeler

2008

Neuroscience & Biobehavioral Reviews

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“…129X1/sVJ mice showed a locomotor stimulatory effect of heroin, but they did not develop conditioned place preference to the dose administered, rather they expressed place aversion [31]. Interestingly, 129P3/J mice failed to develop physical dependence to morphine as assessed by naloxone precipitated jumping [12]. Thus, 129P3/J mice may be relatively insensitive to the effects of drugs of abuse in general.…”

Section: Introductionmentioning

confidence: 97%

Heroin-induced locomotor activity and conditioned place preference in C57BL/6J and 129P3/J mice

Schlussman

Zhang

Hsu

et al. 2008

Neuroscience Letters

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Differences in the locomotor stimulating and rewarding properties of drugs of abuse have been described in several inbred strains of mice, and comparisons of inbred strains with differing responses to drugs of abuse may provide crucial insight into the question of individual vulnerability to the effects of drugs of abuse. The present study was designed to examine the rewarding and locomotorstimulating effects of heroin in C57BL/6J and 129P3/J mice. Heroin produced a robust dose dependent locomotor stimulation in both strains. Both strains also developed conditioned place preference to heroin, again in a dose dependent manner. However C57BL/6J mice developed conditioned place preference to only the two lowest doses of heroin tested, while the 129P3/J counterparts showed conditioned place preference to only the three highest doses tested. These studies indicate that 129P3/J mice are less sensitive to the rewarding effects of heroin than are agematched C57BL/6J mice.

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“…Using one dozen or more strains of inbred mice, several reports are available demonstrating a high degree of heritability of both tolerance and dependence [21,22,30]. Recently our laboratory used a panel of inbred mice coupled with an in silico haplotypic mapping algorithm to associate the beta-2 adrenergic receptor (β2-AR) gene with OIH [33].…”

Section: Introductionmentioning

confidence: 99%

The β2 adrenergic receptor regulates morphine tolerance and physical dependence

Liang

Shi

et al. 2007

Behavioural Brain Research

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Adaptations to the chronic administration of opioids reduce the utility of these drugs in treating pain and support addiction. Recent genetics-based approaches have implicated the β2 adrenergic receptor (β2-AR) in controlling some of these responses. We do not know, however, whether this receptor can modulate tolerance, dependence or changes in gene expression caused by chronic opioid administration. For our studies we used C57BL/6 mice and β2-AR knockout mice in the FVB background. Morphine dose response relationships were established both prior to and after chronic morphine treatment. In some cases, the selective β2-AR antagonist butoxamine was administered along with or after morphine. Physical dependence was assessed using naloxone-precipitated withdrawal. The expression of calcitonin gene related peptide (CGRP) and substance P (SP) were measured in spinal cord and dorsal root ganglion (DRG) tissues using both real-time PCR and enzyme-linked immunoassay (ELISA). Both the co-administration of butoxamine with morphine and the administration of butoxamine after chronic morphine reversed morphine tolerance. Morphine failed to cause tolerance in β2-AR knockout mice. Physical dependence was reduced under the same circumstances. The chronic administration of butoxamine with morphine reduced or eliminated the normally observed up-regulation of CGRP and SP in spinal cord and DRG tissues. Our results suggest that the β2-AR modulates both opioid tolerance and physical dependence. Activation of β2-ARs appears to be required for some of the key neurochemical changes which characterize chronic opioid administration. Therefore β2-AR antagonists show some promise as agents to enhance chronic opioid analgesic therapy.

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Naloxone-precipitated withdrawal jumping in 11 inbred mouse strains: evidence for common genetic mechanisms in acute and chronic morphine physical dependence

Cited by 123 publications

References 27 publications

Behavioral genetic contributions to the study of addiction-related amphetamine effects

Behavioral genetic contributions to the study of addiction-related amphetamine effects

Heroin-induced locomotor activity and conditioned place preference in C57BL/6J and 129P3/J mice

The β2 adrenergic receptor regulates morphine tolerance and physical dependence

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