Naloxone inhibits intermale aggression in isolated mice

Lynch, Wesley C.; Libby, L. S.; Johnson, H. F.

doi:10.1007/bf00433421

Cited by 37 publications

(2 citation statements)

References 10 publications

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“…Further, treatments and pharmacological substances that blunt the associated reward of certain behaviors may be viable avenues to subdue the aggression of violent offenders who seek the ‘kick’ of positive affect that aggression likely yields. As early evidence, naloxone, an opioid antagonist frequently used to prevent fatal overdose among opioid-dependent individuals (e.g., heroin users), has been linked to lesser aggression in mice (Lynch, Libby, & Johnson, 1983). Indeed, it may be that aggressive behavior closely mirrors that of addictive behaviors in that it results in a short-term improvement in mood and that this motivates individuals to seek out this behavior.…”

Section: Discussionmentioning

confidence: 99%

Combating the sting of rejection with the pleasure of revenge: A new look at how emotion shapes aggression.

Chester

DeWall

2017

Journal of Personality and Social Psychology

122

118

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How does emotion explain the relationship between social rejection and aggression? Rejection reliably damages mood, leaving individuals motivated to repair their negatively valenced affective state. Retaliatory aggression is often a pleasant experience. Rejected individuals may then harness revenge's associated positive affect to repair their mood. Across 6 studies (total N = 1,516), we tested the prediction that the rejection-aggression link is motivated by expected and actual mood repair. Further, we predicted that this mood repair would occur through the positive affect of retaliatory aggression. Supporting these predictions, naturally occurring (Studies 1 and 2) and experimentally manipulated (Studies 3 and 4) motives to repair mood via aggression moderated the rejection-aggression link. These effects were mediated by sadistic impulses toward finding aggression pleasant (Studies 2 and 4). Suggesting the occurrence of actual mood repair, rejected participants' affective states were equivalent to their accepted counterparts after an act of aggression (Studies 5 and 6). This mood repair occurred through a dynamic interplay between preaggression affect and aggression itself, and was driven by increases in positive affect (Studies 5 and 6). Together, these findings suggest that the rejection-aggression link is driven, in part, by the desire to return to affective homeostasis. Additionally, these findings implicate aggression's rewarding nature as an incentive for rejected individuals' violent tendencies. (PsycINFO Database Record

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Section: Discussionmentioning

confidence: 99%

Combating the sting of rejection with the pleasure of revenge: A new look at how emotion shapes aggression.

Chester

DeWall

2017

Journal of Personality and Social Psychology

122

118

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“…Naloxone decreases isolation induced mouse fighting (Lynch et al 1983;Rodgers and Hendrie 1983). In isolated resident mice, naloxone causes decreases in offensive biting attack and threat behaviors toward intruders (Olivier and van Dalen 1982;Puglisi-Allegra et al 1984), and causes increaes in defensive behavior in intruders (Rodgers and Hendrie 1984).…”

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confidence: 99%

Aggression during morphine withdrawal: Effects of method of withdrawal, fighting experience, and social role

Kantak

Miczek

1986

Psychopharmacology

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Offensive and defensive components of aggressive behavior were determined in resident and intruder mice. Withdrawal aggression was measured after the removal of a subcutaneous morphine pellet or after precipitation by naloxone in naive mice and after removal of a morphine pellet in mice with prior fighting experience. In naive mice, removal of a morphine pellet led to increases in attack bites and threats but naloxone-precipitated withdrawal led to decreases in these behaviors and to increases in defensive posturing, escape attempts and vocalizations. Prior fighting experience abolished the enhanced attack behaviors of resident mice following morphine pellet removal, but led to heightened defensive behavior in intruder mice. The behavior of intruder mice appeared more sensitive to naloxone administration than the behavior of resident mice; naloxone influenced not only intruder defensive behavior, but also other non-aggressive behaviors. The social role of the drug recipient and his prior history of aggressive behavior are important determinants of morphine and naloxone effects on aggression.

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The long-term effects of naloxone, dibutyryl cyclic CMP, and chlorpromazine on aggression in mice monitored by an automated device

Benton

1984

Aggr. Behav.

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Naloxone inhibits intermale aggression in isolated mice

Cited by 37 publications

References 10 publications

Combating the sting of rejection with the pleasure of revenge: A new look at how emotion shapes aggression.

Combating the sting of rejection with the pleasure of revenge: A new look at how emotion shapes aggression.

Aggression during morphine withdrawal: Effects of method of withdrawal, fighting experience, and social role

The long-term effects of naloxone, dibutyryl cyclic CMP, and chlorpromazine on aggression in mice monitored by an automated device

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