Naloxone-induced increase in blood and brain ethanol concentrations in rats

Benitez, Maria-José; Boada, J; Díaz, Eduardo González; Feria, Manuel; Prunell, M

doi:10.1016/0031-6989(87)90102-0

Cited by 7 publications

(1 citation statement)

References 9 publications

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“…There were some occasional reports that opioid antagonists could affect ethanol absorption and modify BECs, although there was inconsistency in the directionality of these effects. For instance, Linseman and Lê (1997) reported naltrexone‐induced decreases in BECs following intragastric ethanol administration, whereas Benitez and others (1987) found that brain and blood ethanol levels were elevated following naloxone and the same route of ethanol administration. Assessment of BECs in the present study, however, revealed no effects of naloxone or CTOP administration, confirming that under the circumstances of these tests, both antagonists blocked the socially activating effects of ethanol without altering its pharmacokinetic properties.…”

Section: Discussioncontrasting

confidence: 99%

Ethanol‐Induced Social Facilitation in Adolescent Rats: Role of Endogenous Activity at Mu Opioid Receptors

Varlinskaya

Spear

2009

Alcoholism Clin & Exp Res

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Background-Ethanol consumption is considerably elevated during adolescence. Attractiveness of alcohol for humans during the adolescent developmental period is based, in part, on its ability to induce social facilitation-a facilitation of social interactions not only evident in human adolescents but also in adolescent rats. Endogenous opioid systems are among the multiple neural systems implicated in the behavioral and reinforcing effects of ethanol and may play a substantial role in modulating stimulatory effects of low doses of ethanol on social behavior during adolescence. This possibility was explored in the present study through the use of an animal model of peer-directed social behavior.

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Section: Discussioncontrasting

confidence: 99%