Naloxone-blocked depriming effect of anxiolytic selank on apomorphine-induced behavioral manifestations of hyperfunction of dopamine system

Meshavkin, V. K.; Кост, Н. В.; Sokolov, O. Yu.; Zolotarev, Yu. A.; Myasoedov, N. F.; Zozulya, A. A.

doi:10.1007/s10517-006-0428-1

Cited by 3 publications

(2 citation statements)

References 10 publications

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“…Activation of this gene by Selank at early and later times suggests an ability of the peptide to influence processes involved in synaptic plasticity and thereby render nootropic action. It has been shown previously that Selank modulates dopamine and serotonin receptors, which play a role in the stimulation of mental activity and in the pathogenesis of anxiety (Meshavkin et al, 2006 ).…”

Section: Discussionmentioning

confidence: 99%

Selank Administration Affects the Expression of Some Genes Involved in GABAergic Neurotransmission

et al. 2016

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Clinical studies have shown the similarity of the spectrum of physiological effects of Selank and classical benzodiazepines, such as diazepam and phenazepam. These data suggest that there is a similar basis of their mechanism of action. To test this hypothesis we studied the effect of Selank and GABA on the expression of genes involved in neurotransmission. We analyzed the expression of 84 genes involved in neurotransmission (e.g., major subunit of the GABA receptor, transporters, ion channels, dopamine, and serotonin receptors) in the frontal cortex of rats 1 and 3 h after the administration of Selank or GABA (300 μg/kg) using real-time PCR method. We found significant changes in the expression of 45 genes 1 h after the administration of the compounds. Three hours after Selank or GABA administration, 22 genes changed their expression. We found positive correlation between the changes in genes expression within 1 h after administration of Selank or GABA. Our results showed that Selank caused a number of alterations in the expression of genes involved in neurotransmission. The data obtained indicate that Selank is characterized by its complex effects on nerve cells, and one of its possible molecular mechanisms is associated with allosteric modulation of the GABAergic system.

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Section: Discussionmentioning

confidence: 99%

Selank Administration Affects the Expression of Some Genes Involved in GABAergic Neurotransmission

et al. 2016

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“…However, the direct binding of the peptide to dopamine and opioid receptors has been reported. As enkephalinase inhibitors together with opioid receptor agonists and antagonists modulate the status of the dopaminergic system, the authors assumed that the effect of Selank is mediated by its ability to modulate the status of the endogenous opioid system via changes in the activity of enkephalindegrading enzymes [158].…”

Section: Anxiolytic Effectmentioning

confidence: 99%

A New Generation of Drugs: Synthetic Peptides Based on Natural Regulatory Peptides

Kolomin¹,

Шадрина²,

Slominsky³

et al. 2013

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Natural regulatory peptides are biologically active compounds that are produced by various cells and provide a link among the main regulatory systems of the body. The field of research into the biologic activity of endogenous regulatory peptides is extremely vast. These peptides affect the cardiovascular, immune, reproductive, endocrine, digestive, and other systems, alter energy metabolism, and are especially effective in the regulation of the central nervous system. Despite of the wide range of preventive and therapeutic effects of natural regulatory peptides and proteins, their application in clinical practice is difficult. This is primarily because of their extreme instability, as they are rapidly degraded by proteases of the gastrointestinal tract, blood, cerebrospinal fluid, and other biologic media. Compounds with higher stability (i.e., a considerably longer half-life compared with that of natural molecules) and the ability to provide a directional effect on the various body systems were obtained from modifications of endogenous regulatory peptides. Synthetic analogs of regulatory peptides, as a rule, contain only natural amino acids in their composition, and their biodegradation does not lead to the formation of toxic products; thus, they have fewer side effects. This review focuses on the consideration of two synthetic regulatory peptides, Semax and Selank, which were the bases for the creation of new drugs that are used effectively in the treatment of various diseases of the nervous system. The synthetic analog of an adrenocorticotropic hormone 4-10 fragment (ACTH 4-10) Semax is a powerful neuroprotective agent that is particularly effective as a therapy for stroke. Selank was synthesized on the basis of the natural immunomodulator tuftsin. Selank is a powerful anxiolytic that is used as a therapy for generalized anxiety disorder and neurasthenia without sedative and muscle-relaxant effects. This review presents the results of research aimed at studying the influence of these peptides on the transcriptome of brain cells. The problems of drugs developed based on the clinical activities of Semax and Selank are discussed separately.

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Physiological Effects of Selank and Its Fragments

Koroleva

Mjasoedov

2019

Biol Bull Russ Acad Sci

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Naloxone-blocked depriming effect of anxiolytic selank on apomorphine-induced behavioral manifestations of hyperfunction of dopamine system

Cited by 3 publications

References 10 publications

Selank Administration Affects the Expression of Some Genes Involved in GABAergic Neurotransmission

Selank Administration Affects the Expression of Some Genes Involved in GABAergic Neurotransmission

A New Generation of Drugs: Synthetic Peptides Based on Natural Regulatory Peptides

Physiological Effects of Selank and Its Fragments

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